Hyperhomocysteinemia in a Gammopathy Patient: Malnutrition or Interference? [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Charifa, A., El-Khoury, J. M. Tags: What Is Your Guess? Source Type: research
An Unexpected Low HbA1c: Measurement Error or Interpretation Problem? [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Lenters-Westra, E., den Besten, G., Slingerland, R. J. Tags: Other Areas of Clinical Chemistry What Is Your Guess? Source Type: research
Detection of Insulin-Like Growth Factor 1 Variants by Mass Spectrometry: Results from a Clinical Reference Laboratory [Letter to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Wu, Z., Sanders, H., Motorykin, I., Phillip Caulfield, M., John McPhaul, M. Tags: Endocrinology and Metabolism Letter to the Editor Source Type: research
Breast Cancer Subtype Classification Using 4-Plex Droplet Digital PCR [Molecular Diagnostics and Genetics]
CONCLUSIONS:
Evaluation of breast cancer biomarker status by 4-plex ddPCR was highly concordant with IHC in this study. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Chen, W., Zheng, J., Wu, C., Liu, S., Chen, Y., Liu, X., Du, J., Wang, J. Tags: Molecular Diagnostics and Genetics Source Type: research
Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
These corroborative large-scale findings provide further support for a potential protective role of HDL-CEC in CHD and substantiate this new method and its future applications. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Kuusisto, S., Holmes, M. V., Ohukainen, P., Kangas, A. J., Karsikas, M., Tiainen, M., Perola, M., Salomaa, V., Kettunen, J., Ala-Korpela, M. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
European Biological Variation Study (EuBIVAS): Within- and Between-Subject Biological Variation Data for 15 Frequently Measured Proteins [Proteomics and Protein Markers]
CONCLUSIONS:
In addition to new BV estimates for sTfR, this EuBIVAS substudy generated more demanding APS for frequently requested plasma specific proteins. APS for CRP should not be calculated from BV data except when CRP is used as a risk factor for cardiovascular disease. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Carobene, A., Aarsand, A. K., Guerra, E., Bartlett, W. A., Coşkun, A., Diaz-Garzon, J., Fernandez-Calle, P., Jonker, N., Locatelli, M., Sandberg, S., Ceriotti, F., on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine W Tags: Proteomics and Protein Markers Source Type: research
Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries [Proteomics and Protein Markers]
CONCLUSIONS:
Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Hjort, M., Eggers, K. M., Lindhagen, L., Agewall, S., Brolin, E. B., Collste, O., Daniel, M., Ekenback, C., Frick, M., Henareh, L., Hofman-Bang, C., Malmqvist, K., Spaak, J., Sorensson, P., Y-Hassan, S., Tornvall, P., Lindahl, B. Tags: Proteomics and Protein Markers Source Type: research
Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Coupled MALDI-TOF Mass Spectrometry [Proteomics and Protein Markers]
CONCLUSIONS:
FLC immunoenrichment coupled to MALDI-TOF MS enables direct detection of mFLCs and significantly increases the confirmation of abnormal serum FLC ratios over IFE and MALDI-TOF MS without FLC enrichment, thereby providing added confidence for diagnosing FLC PCDs. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Sepiashvili, L., Kohlhagen, M. C., Snyder, M. R., Willrich, M. A. V., Mills, J. R., Dispenzieri, A., Murray, D. L. Tags: Proteomics and Protein Markers Source Type: research
Diagnostic Accuracy of a High-Sensitivity Cardiac Troponin Assay with a Single Serum Test in the Emergency Department [Proteomics and Protein Markers]
CONCLUSIONS:
The hs-cTnI assay could immediately rule out AMI in 40% of patients and ACS in >25%, with similar accuracy to hs-cTnT at the LoD. Because of its high precision at low concentrations, this hs-cTnI assay has favorable characteristics for this clinical application. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Body, R., Twerenbold, R., Austin, C., Boeddinghaus, J., Almashali, M., Nestelberger, T., Morris, N., Badertscher, P., McDowell, G., Wildi, K., Moss, P., Rubini Gimenez, M., Jarman, H., Bigler, N., Einemann, R., Koechlin, L., Pourmahram, G., Todd, J., Muel Tags: Proteomics and Protein Markers Source Type: research
A Bayesian Approach to Biological Variation Analysis [Informatics and Statistics]
CONCLUSIONS:
The recommended Bayesian approach gives a clear picture of the degree of heterogeneity, and the ability to crudely estimate personal within-participant CVs can be used to explore relevant subgroups. Because BV experiments are expensive and time-consuming, prior knowledge and estimates should be considered of high value and applied accordingly. By including reliable prior knowledge, precise estimates are possible even with small data sets. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Roraas, T., Sandberg, S., Aarsand, A. K., Stove, B. Tags: Informatics and Statistics Source Type: research
Diagnosis of Hemoglobinopathy and {beta}-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood [Hematology]
CONCLUSIONS:
We found that 21 T FT-ICR MS/MS provides a benchmark for top-down MS/MS analysis of blood Hb. The present method has the potential to be translated to lower resolving power mass spectrometers (lower field FT-ICR mass spectrometry and Orbitrap) for Hb variant analysis (by MS1 and MS2) and β-thalassemia diagnosis (MS1). (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: He, L., Rockwood, A. L., Agarwal, A. M., Anderson, L. C., Weisbrod, C. R., Hendrickson, C. L., Marshall, A. G. Tags: Hematology Source Type: research
Single-Cell Genomics [Review]
We describe opportunities in clinical research and medical applications. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Paolillo, C., Londin, E., Fortina, P. Tags: Molecular Diagnostics and Genetics Review Source Type: research
Patient-Based Real-Time Quality Control: Review and Recommendations [Special Report]
In this report, we will restrict the discussion to population-based parameters. This overview is intended to serve as a guide for the implementation of a patient-based QC system. The report does not cover the clinical evaluation of the population. (Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Badrick, T., Bietenbeck, A., Cervinski, M. A., Katayev, A., van Rossum, H. H., Loh, T. P., on behalf of the International Federation of Clinical Chemistry, and Laboratory Medicine Committee on Analytical Quality Tags: Laboratory Management Special Report Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Tapper, E. B. Tags: Clinical Case Study Source Type: research
