Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Coupled MALDI-TOF Mass Spectrometry [Proteomics and Protein Markers]

CONCLUSIONS:
FLC immunoenrichment coupled to MALDI-TOF MS enables direct detection of mFLCs and significantly increases the confirmation of abnormal serum FLC ratios over IFE and MALDI-TOF MS without FLC enrichment, thereby providing added confidence for diagnosing FLC PCDs.

Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: Sepiashvili, L., Kohlhagen, M. C., Snyder, M. R., Willrich, M. A. V., Mills, J. R., Dispenzieri, A., Murray, D. L. Tags: Proteomics and Protein Markers Source Type: research