Low-Grade Inflammation in the Association between Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis: A Study of More Than 115000 Individuals from the General Population [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
Mild-to-moderate hypertriglyceridemia is associated with low-grade inflammation and higher risk of acute pancreatitis. The association between mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis is possibly partly mediated by low-grade inflammation. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Hansen, S. E. J., Madsen, C. M., Varbo, A., Nordestgaard, B. G. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
Evaluation of the Non-HDL Cholesterol to Apolipoprotein B Ratio as a Screening Test for Dysbetalipoproteinemia [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
NHDLC/apoB offers a simple first-line test for dysbetalipoproteinemia in selecting patients with mixed hyperlipidemia for more complex investigations. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Boot, C. S., Middling, E., Allen, J., Neely, R. D. G. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain [Evidence-Based Medicine and Test Utilization]
CONCLUSIONS:
Interleukin-6 significantly improves the early diagnosis of UAP in the ED. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Breidthardt, T., Brunner-Schaub, N., Balmelli, C., Insenser, J. J. S., Burri-Winkler, K., Geigy, N., Mundorff, L., Exadaktylos, A., Scholz, J., Haaf, P., Hamel, C., Frey, D., Delport, K., Peacock, W. F., Freese, M., DiSomma, S., Todd, J., Rentsch, K., Bin Tags: Evidence-Based Medicine and Test Utilization Source Type: research
Completeness of Reporting of Systematic Reviews of Diagnostic Test Accuracy Based on the PRISMA-DTA Reporting Guideline [Evidence-Based Medicine and Test Utilization]
CONCLUSIONS:
Recently published reports of DTA systematic reviews are not fully informative when evaluated against the PRISMA-DTA guidelines. These results should guide knowledge translation strategies, including journal level (e.g., PRISMA-DTA adoption, increased abstract word count, and use of supplementary material) and author level (PRISMA-DTA citation awareness) strategies. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Salameh, J.-P., McInnes, M. D. F., Moher, D., Thombs, B. D., McGrath, T. A., Frank, R., Dehmoobad Sharifabadi, A., Kraaijpoel, N., Levis, B., Bossuyt, P. M. Tags: Evidence-Based Medicine and Test Utilization Source Type: research
Development and Validation of Apolipoprotein AI-Associated Lipoprotein Proteome Panel for the Prediction of Cholesterol Efflux Capacity and Coronary Artery Disease [Proteomics and Protein Markers]
CONCLUSIONS:
Development of a proteomic pCE provides a reproducible high-throughput alternative to traditional cell-based CEC assays. The pCAD model improves stratification of case and control cohorts and, with further studies to establish clinical validity, presents a new opportunity for the assessment of cardiovascular health. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Jin, Z., Collier, T. S., Dai, D. L. Y., Chen, V., Hollander, Z., Ng, R. T., McManus, B. M., Balshaw, R., Apostolidou, S., Penn, M. S., Bystrom, C. Tags: Proteomics and Protein Markers Source Type: research
Concurrent Single-Cell RNA and Targeted DNA Sequencing on an Automated Platform for Comeasurement of Genomic and Transcriptomic Signatures [Automation and Analytical Techniques]
CONCLUSIONS:
CORTAD-seq allows assessment of the interconnection between genetic and transcriptomic changes in single cells. It is operated on an automated, commercially available single-cell isolation platform, making its implementation straightforward. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Kong, S. L., Li, H., Tai, J. A., Courtois, E. T., Poh, H. M., Lau, D. P., Haw, Y. X., Iyer, N. G., Tan, D. S. W., Prabhakar, S., Ruff, D., Hillmer, A. M. Tags: Automation and Analytical Techniques Source Type: research
Integrated Extreme Real-Time PCR and High-Speed Melting Analysis in 52 to 87 Seconds [Molecular Diagnostics and Genetics]
CONCLUSIONS:
Extreme PCR with high-speed melting can be performed in about 1 min. The integration of extreme PCR and high-speed melting shows that future molecular assays at the point of care for identification, quantification, and variant typing are feasible. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Myrick, J. T., Pryor, R. J., Palais, R. A., Ison, S. J., Sanford, L., Dwight, Z. L., Huuskonen, J. J., Sundberg, S. O., Wittwer, C. T. Tags: Molecular Diagnostics and Genetics Source Type: research
Advances in the Treatment of Hemophilia: Implications for Laboratory Testing [Reviews]
BACKGROUND:
Until recently, clinical laboratories have monitored hemophilia treatment by measuring coagulation factors before/after infusion of human-derived or recombinant factors. Substantial changes are expected in the near future based on new therapeutic approaches that have been or are being developed.
CONTENT:
Hemophilia treatment includes replacement therapy with human-derived/recombinant factors or treatment with bypassing agents for patients without or with inhibitors, respectively. Accordingly, laboratory methods for monitoring include one-stage clotting or chromogenic assays meant to measure either factor VIII/...
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Tripodi, A., Chantarangkul, V., Novembrino, C., Peyvandi, F. Tags: Hemostasis and Thrombosis Reviews Source Type: research
The Fentanyl Epidemic and Evolution of Fentanyl Analogs in the United States and the European Union [Reviews]
BACKGROUND:
Since 2013, an unprecedented surge in fentanyl overdose deaths has been caused by heroin laced with illicitly produced fentanyl and/or fentanyl analogs (FAs) sold as heroin. The US Drug Enforcement Agency's National Forensic Laboratory Information System reported a >300% increase in fentanyl encounters from 4697 in 2014 to 14440 in 2015. In 2015, the CDC reported 9580 deaths caused by synthetic opioids, primarily fentanyl, a 72% increase from 2014. The European Monitoring Centre for Drugs and Drug Addiction has also encountered several new FAs in the heroin supply. Counterfeit pharmaceuticals containing mixt...
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Jannetto, P. J., Helander, A., Garg, U., Janis, G. C., Goldberger, B., Ketha, H. Tags: Drug Monitoring and Toxicology Reviews Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: French, D. Tags: Clinical Case Study Source Type: research
A Question of Opioid Diversion or Compliance [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Cervinski, M. A., Jannetto, P. J. Tags: Clinical Case Studies, Drug Monitoring and Toxicology Clinical Case Study Source Type: research
Maintaining Research and Publication Integrity [Q&A]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Rifai, N., Annesley, T. M., Moore, S., Caplan, A. L., Sweet, D. J., Hornung, P., Rosendaal, F. R. Tags: Other Areas of Clinical Chemistry Q & amp;A Source Type: research
Presymptomatic Noninvasive Assessment of Fetal Well-being by Genome-wide RNA Sequencing [Perspective]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Oudejans, C. B. M. Tags: Molecular Diagnostics and Genetics, Perspective Source Type: research
Type III Hyperlipoproteinemia: The Forgotten, Disregarded, Neglected, Overlooked, Ignored but Highly Atherogenic, and Highly Treatable Dyslipoproteinemia [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - January 28, 2019 Category: Chemistry Authors: Sniderman, A. D. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Editorials Source Type: research
