Answering Unanswerable Questions in the Clinical Laboratory with Data Warehouses [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: Jackups, R. Tags: Informatics and Statistics Editorials Source Type: research
Effect of Vitamin D and Omega-3 Supplements on Systemic Inflammation [Editorials]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - November 26, 2019 Category: Chemistry Authors: McKinley, M. C. Tags: Nutrition Editorials Source Type: research
A Patient's Hands [Unveiling the Right Side]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Hoekstra, K. A. Tags: Unveiling the Right Side Source Type: research
Going Batty [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Webber, D. M., Yarbrough, M. L. Tags: What Is Your Guess? Source Type: research
Child with Discrepant Urine Protein Results [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Vaudran, L., Schraen, S., Kim, I., Dessein, A.-F., Onraed, B. Tags: What Is Your Guess? Source Type: research
Sawtooth Potassium and Hemoglobin Results [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Musson, R. E. A., Huisman, A., Nonkes, L. J. P., Kemperman, H. Tags: What Is Your Guess? Source Type: research
Abnormal Ketone Bodies in a 22-Month-Old Boy Presenting with Recurrent Vomiting and Metabolic Acidosis [Genetic Metabolic Series]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Bancel, L.-P., Germain, N., Guemann, A.-S., Joncquel Chevalier Curt, M., Dessein, A.-F. Tags: Pediatric Clinical Chemistry Genetic Metabolic Series Source Type: research
MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes [Letter to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Monteiro, M. B., Santos-Bezerra, D. P., Pelaes, T. S., Vaidya, V. S., Correa-Giannella, M. L. Tags: Molecular Diagnostics and Genetics Letter to the Editor Source Type: research
Cardiac and Stress Biomarkers and Chronic Kidney Disease Progression: The CRIC Study [Other Areas of Clinical Chemistry]
CONCLUSIONS:
Increases in GDF-15, NT-proBNP, and hsTnT are associated with greater risk for CKD progression. These biomarkers may inform mechanisms underlying kidney injury. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Bansal, N., Zelnick, L., Shlipak, M. G., Anderson, A., Christenson, R., Deo, R., deFilippi, C., Feldman, H., Lash, J., He, J., Kusek, J., Ky, B., Seliger, S., Soliman, E. Z., Go, A. S., on behalf of the CRIC Study Investigators Tags: Other Areas of Clinical Chemistry Source Type: research
Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay [General Clinical Chemistry]
CONCLUSIONS:
Safety and efficacy of the l hs-cTnI-Access 0/2-h algorithm for triage toward rule-out or rule-in of AMI are very high.
TRIAL REGISTRATION:
APACE, NCT00470587; ADAPT, ACTRN1261100106994; IMPACT, ACTRN12611000206921. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Nestelberger, T., Boeddinghaus, J., Greenslade, J., Parsonage, W. A., Than, M., Wussler, D., Lopez-Ayala, P., Zimmermann, T., Meier, M., Troester, V., Badertscher, P., Koechlin, L., Wildi, K., Anwar, M., Freese, M., Keller, D. I., Reichlin, T., Twerenbold Tags: General Clinical Chemistry Source Type: research
Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction [Proteomics and Protein Markers]
CONCLUSIONS:
The hs-cTnI-VITROS assay has at least comparable diagnostic accuracy with the currently best validated hs-cTnT and hs-cTnI assays.
ClinicalTrials.gov Identifier:
NCT00470587. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Boeddinghaus, J., Twerenbold, R., Nestelberger, T., Koechlin, L., Wussler, D., Meier, M., Troester, V., Zimmermann, T., Badertscher, P., Wildi, K., Rubini Gimenez, M., Lopez-Ayala, P., Potlukova, E., Miro, O., Martin-Sanchez, F. J., Kawecki, D., Geigy, N. Tags: Proteomics and Protein Markers Source Type: research
5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes [Molecular Diagnostics and Genetics]
CONCLUSIONS:
The 5hmC markers in cfDNA reflected the epigenetic changes in patients with T2D who developed macrovascular/microvascular complications. The 5hmC-Seal assay has the potential to be a clinically convenient, noninvasive approach that can be applied in the clinic to monitor the presence and severity of diabetic vascular complications. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Yang, Y., Zeng, C., Lu, X., Song, Y., Nie, J., Ran, R., Zhang, Z., He, C., Zhang, W., Liu, S.-M. Tags: Molecular Diagnostics and Genetics Source Type: research
Comparison of BEAMing and Droplet Digital PCR for Circulating Tumor DNA Analysis [Cancer Diagnostics]
CONCLUSIONS:
This large, clinically relevant comparison showed good agreement between BEAMing and ddPCR, suggesting sufficient reproducibility for clinical use. Much of the observed discordancy may be related to sampling effects, potentially explaining many of the differences in the currently available ctDNA literature. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: O'Leary, B., Hrebien, S., Beaney, M., Fribbens, C., Garcia-Murillas, I., Jiang, J., Li, Y., Huang Bartlett, C., Andre, F., Loibl, S., Loi, S., Cristofanilli, M., Turner, N. C. Tags: Cancer Diagnostics (since 2002) Source Type: research
An Intact ACTH LC-MS/MS Assay as an Arbiter of Clinically Discordant Immunoassay Results [Endocrinology and Metabolism]
CONCLUSIONS:
Immunoprecipitation of biologically active ACTH molecules followed by LC-MS/MS analysis enabled selective detection of iACTH and relevant biologically active fragments in plasma. Applied to the investigation of clinically discrepant results, this method can act as an arbiter of the concentration of iACTH present. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: Shi, J., Dhaliwal, P., Zi Zheng, Y., Wong, T., Straseski, J. A., Cervinski, M. A., Shajani-Yi, Z., DeMarco, M. L. Tags: Endocrinology and Metabolism Source Type: research
Quantitative Profiling of Platelet-Rich Plasma Indole Markers by Direct-Matrix Derivatization Combined with LC-MS/MS in Patients with Neuroendocrine Tumors [Endocrinology and Metabolism]
CONCLUSIONS:
Direct-matrix derivatization in combination with LC-MS/MS is a powerful tool for the simultaneous quantification of all tryptophan-related indoles in platelet-rich plasma. Simultaneous profiling of relevant indoles improves the biochemical characterization and follow-up of NETs. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2019 Category: Chemistry Authors: van Faassen, M., Bouma, G., de Hosson, L. D., Peters, M. A. M., Kats-Ugurlu, G., de Vries, E. G. E., Walenkamp, A. M. E., Kema, I. P. Tags: Endocrinology and Metabolism Source Type: research
