A 63-Year-Old Man with Markedly Increased Whole Blood Lactate and Discrepant Plasma Lactate Values [What Is Your Guess?]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Zhou, H., McCoy, D. G., Scott, M. G. Tags: General Clinical Chemistry What Is Your Guess? Source Type: research
Measurement of Treatment Effects Requires Instruments Responsive to Change Based on the Minimal Important Difference [Citation Classic]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Johnston, B. C., Guyatt, G. H. Tags: Other Areas of Clinical Chemistry, Citation Classics Source Type: research
In Reply [Letters to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Smith, J. D., Wilson, S., Schneider, H. G. Tags: Letters to the Editor Source Type: research
Albumin-Adjusted Calcium and Ionized Calcium [Letters to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Payne, R. B. Tags: Letters to the Editor Source Type: research
Albumin-Adjusted Calcium and Ionized Calcium for Assessing Calcium Status in Hospitalized Patients [Letters to the Editor]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Grzych, G., Pekar, J. D., Durand, G., Deckmyn, B., Maboudou, P., Lippi, G. Tags: Current Issues in Laboratory Medicine Letters to the Editor Source Type: research
Parameters for Validating a Hospital Pneumatic Tube System [Other Areas of Clinical Chemistry]
CONCLUSIONS:
Hospital PTSs can be validated by documenting the relationship between the concentrations of analytes in plasma, such as LD, with PTS forces recorded by 3-axis accelerometers. Implementation of this method for PTS validation is relatively inexpensive, simple, and robust. (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Farnsworth, C. W., Webber, D. M., Krekeler, J. A., Budelier, M. M., Bartlett, N. L., Gronowski, A. M. Tags: Other Areas of Clinical Chemistry Source Type: research
Effect of Smoked Cannabis on Vigilance and Accident Risk Using Simulated Driving in Occasional and Chronic Users and the Pharmacokinetic-Pharmacodynamic Relationship [Drug Monitoring and Toxicology]
CONCLUSIONS:
Inhalation from cannabis joints leads to a rapid increase in blood THC with a delayed decrease in vigilance and driving performance, more pronounced and lasting longer in OC than in CC. ClinicalTrials.gov Identifier: NCT02061020 (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Hartley, S., Simon, N., Larabi, A., Vaugier, I., Barbot, F., Quera-Salva, M.-A., Alvarez, J. C. Tags: Drug Monitoring and Toxicology Source Type: research
Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer [Cancer Diagnostics]
CONCLUSIONS:
The MasSpec Pen, together with machine learning, provides robust molecular models for ovarian serous cancer prediction and thus has potential for clinical use for rapid and accurate ovarian cancer diagnosis. (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Sans, M., Zhang, J., Lin, J. Q., Feider, C. L., Giese, N., Breen, M. T., Sebastian, K., Liu, J., Sood, A. K., Eberlin, L. S. Tags: Cancer Diagnostics (since 2002) Source Type: research
Novel Assay for Quantitative Analysis of DNA Methylation at Single-Base Resolution [Molecular Diagnostics and Genetics]
CONCLUSIONS:
This assay is highly specific and sensitive for determining single-base methylation and, thus, is potentially useful for methylation-based panels in diagnostic and prognostic applications. (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Yu, H., Bai, L., Tang, G., Wang, X., Huang, M., Cao, G., Wang, J., Luo, Y. Tags: Molecular Diagnostics and Genetics Source Type: research
Increased Clinical Sensitivity and Specificity of Plasma Protein N-Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection-Electrospray Ionization-Quadrupole Time-of-Flight Mass Spectrometry [Pediatric Clinical Chemistry]
CONCLUSIONS:
The clinical specificity and sensitivity of N-glycan analysis was much improved with this method. Additional CDGs can be diagnosed that would be missed by carbohydrate-deficient transferrin analysis. The assay provides novel biomarkers with diagnostic and potentially therapeutic significance. (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Chen, J., Li, X., Edmondson, A., Meyers, G. D., Izumi, K., Ackermann, A. M., Morava, E., Ficicioglu, C., Bennett, M. J., He, M. Tags: Molecular Diagnostics and Genetics Pediatric Clinical Chemistry Source Type: research
Low HDL Cholesterol and High Risk of Autoimmune Disease: Two Population-Based Cohort Studies Including 117341 Individuals [Lipids, Lipoproteins, and Cardiovascular Risk Factors]
CONCLUSIONS:
Low HDL cholesterol level is associated with high risk of autoimmune disease in individuals from the general population. Our observational findings cannot determine causality. (Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Madsen, C. M., Varbo, A., Nordestgaard, B. G. Tags: Lipids, Lipoproteins, and Cardiovascular Risk Factors Source Type: research
Clinical Microbiology Is Growing Up: The Total Laboratory Automation Revolution [Review]
We describe systems currently enabling total laboratory automation (TLA) for culture-based microbiology testing. We describe the general components of a microbiology automation system and the various functions of these instruments. We then introduce the 2 most widely used systems currently on the market: Becton Dickinson's Kiestra TLA and Copan's WASPLab. We discuss the impact of TLA on metrics such as turnaround time and recovery of microorganisms, providing a review of the current literature and perspectives from laboratory directors, managers, and technical staff. Finally, we provide an outlook for future advances in TL...
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Bailey, A. L., Ledeboer, N., Burnham, C.-A. D. Tags: Infectious Disease Review Source Type: research
Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA [Special Report]
Circulating cell-free DNA (cfDNA) isolated from blood has been identified as a potential biomarker in numerous fields, and has been the object of intensive research over the past decade, although its original discovery dates back 60 years. While it is already used routinely in commercial and clinical practice in oncology and prenatal testing, other potential applications have emerged, including for diabetes, cardiovascular diseases, organ transplantation, autoimmune diseases, sepsis, trauma, and sport management. As with the discovery and development of any biomarker, preanalytical requirements and documentation are as imp...
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Meddeb, R., Pisareva, E., Thierry, A. R. Tags: Molecular Diagnostics and Genetics Special Report Source Type: research
Commentary [Clinical Case Study]
(Source: Clinical Chemistry)
Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Keren, D. F. Tags: Clinical Case Study Source Type: research
