Increased Clinical Sensitivity and Specificity of Plasma Protein N-Glycan Profiling for Diagnosing Congenital Disorders of Glycosylation by Use of Flow Injection-Electrospray Ionization-Quadrupole Time-of-Flight Mass Spectrometry [Pediatric Clinical Chemistry]

CONCLUSIONS:
The clinical specificity and sensitivity of N-glycan analysis was much improved with this method. Additional CDGs can be diagnosed that would be missed by carbohydrate-deficient transferrin analysis. The assay provides novel biomarkers with diagnostic and potentially therapeutic significance.

Source: Clinical Chemistry - April 28, 2019 Category: Chemistry Authors: Chen, J., Li, X., Edmondson, A., Meyers, G. D., Izumi, K., Ackermann, A. M., Morava, E., Ficicioglu, C., Bennett, M. J., He, M. Tags: Molecular Diagnostics and Genetics Pediatric Clinical Chemistry Source Type: research