Diagnosis of Hemoglobinopathy and {beta}-Thalassemia by 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry of Hemoglobin from Blood [Hematology]

CONCLUSIONS:
We found that 21 T FT-ICR MS/MS provides a benchmark for top-down MS/MS analysis of blood Hb. The present method has the potential to be translated to lower resolving power mass spectrometers (lower field FT-ICR mass spectrometry and Orbitrap) for Hb variant analysis (by MS1 and MS2) and β-thalassemia diagnosis (MS1).

Source: Clinical Chemistry - July 28, 2019 Category: Chemistry Authors: He, L., Rockwood, A. L., Agarwal, A. M., Anderson, L. C., Weisbrod, C. R., Hendrickson, C. L., Marshall, A. G. Tags: Hematology Source Type: research