N ‐methylation in amino acids and peptides: Scope and limitations
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - March 12, 2018 Category: Biochemistry Source Type: research
Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - March 12, 2018 Category: Biochemistry Source Type: research
Understanding and designing head ‐to‐tail cyclic peptides
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - March 12, 2018 Category: Biochemistry Source Type: research
Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - March 12, 2018 Category: Biochemistry Source Type: research
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Biopolymers, Ahead of Print. (Source: Biopolymers)
Source: Biopolymers - March 12, 2018 Category: Biochemistry Source Type: research
Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides
Abstract
While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated improved properties in terms of passive diffusion, permeability across membranes, biostability in human serum and cytotoxicity. Moreover, these brominated tryptophans at positions 5, 6, or 7 proved to be compatible as building blocks to prepare bicyclic stapled peptides by performing on‐resin Suzuki‐Miyaura cross‐coupl...
Source: Biopolymers - March 12, 2018 Category: Biochemistry Authors: J úlia García‐Pindado, Tom Willemse, Rebecca Goss, Bert U. W. Maes, Ernest Giralt, Steven Ballet, Meritxell Teixidó Tags: ORIGINAL ARTICLE Source Type: research
Understanding and designing head ‐to‐tail cyclic peptides
Abstract
Cyclic peptides (CPs) are an exciting class of molecules with a variety of applications. However, design strategies for CP therapeutics, for example, are generally limited by a poor understanding of their sequence–structure relationships. This knowledge gap often leads to a trial‐and‐error approach for designing CPs for a specific purpose, which is both costly and time‐consuming. Herein, we describe the current experimental and computational efforts in understanding and designing head‐to‐tail CPs along with their respective challenges. In addition, we provide several future directions in the field of c...
Source: Biopolymers - March 12, 2018 Category: Biochemistry Authors: Diana P. Slough, Sean M. McHugh, Yu ‐Shan Lin Tags: REVIEW Source Type: research
Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids
Abstract
Gold nanoparticles are known to aggregate in the presence of proper multifunctional compounds. For those larger than 3 nm, the process can be followed with the naked eye because the surface plasmon absorption band of the particles shifts to longer wavelengths and the solution color changes from red to blue. To exploit this property, we have used amino acids and peptides as crosslinking agents in ethanol at low µM concentrations. In the case of amino acids, we report a straightforward protocol for their colorimetric identification. We also report that the presence of precise secondary structure and conformational ...
Source: Biopolymers - March 12, 2018 Category: Biochemistry Authors: Álvaro Martínez, Paolo Scrimin Tags: ORIGINAL ARTICLE Source Type: research
Tailor ‐made computational protocols for precise characterization of small biological building blocks using QM and MM approaches
Biopolymers, EarlyView. (Source: Biopolymers)
Source: Biopolymers - March 9, 2018 Category: Biochemistry Authors: BalasubramanianChandramouli
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SaraDel Galdo
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GiordanoMancini
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NicolaTasinato
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VincenzoBarone Source Type: research
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Biopolymers, Ahead of Print. (Source: Biopolymers)
Source: Biopolymers - March 9, 2018 Category: Biochemistry Source Type: research
