Heparin's solution structure determined by small ‐angle neutron scattering
Abstract
Heparin is a linear, anionic polysaccharide that is widely used as a clinical anticoagulant. Despite its discovery 100 years ago in 1916, the solution structure of heparin remains unknown. The solution shape of heparin has not previously been examined in water under a range of concentrations, and here is done so in D2O solution using small‐angle neutron scattering (SANS). Solutions of 10 kDa heparin—in the millimolar concentration range—were probed with SANS. Our results show that when sodium concentrations are equivalent to the polyelectrolyte's charge or up to a few hundred millimoles higher, the molecula...
Source: Biopolymers - September 21, 2016 Category: Biochemistry Authors: Kenneth A. Rubinson, Yin Chen, Brady F. Cress, Fuming Zhang, Robert J. Linhardt Tags: Article Source Type: research
An ionic –chemical–mechanical model for muscle contraction
Abstract
The dynamic process underlying muscle contraction is the parallel sliding of thin actin filaments along an immobile thick myosin fiber powered by oar‐like movements of protruding myosin cross bridges (myosin heads). The free energy for functioning of the myosin nanomotor comes from the hydrolysis of ATP bound to the myosin heads. The unit step of translational movement is based on a mechanical‐chemical cycle involving ATP binding to myosin, hydrolysis of the bound ATP with ultimate release of the hydrolysis products, stress‐generating conformational changes in the myosin cross bridge, and relief of built‐u...
Source: Biopolymers - September 21, 2016 Category: Biochemistry Authors: Gerald S. Manning Tags: Article Source Type: research
Ocellatin ‐PT antimicrobial peptides: High‐resolution microscopy studies in antileishmania models and interactions with mimetic membrane systems
Abstract
Although the mechanism of action of antimicrobial peptides (AMPs) is not clear, they can interact electrostatically with the cell membranes of microorganisms. New ocellatin‐PT peptides were recently isolated from the skin secretion of Leptodactylus pustulatus. The secondary structure of these AMPs and their effect on Leishmania infantum cells, and on different lipid surface models was characterized in this work. The results showed that all ocellatin‐PT peptides have an α‐helix structure and five of them (PT3, PT4, PT6 to PT8) have leishmanicidal activity; PT1 and PT2 affected the cellular morphology of the ...
Source: Biopolymers - September 21, 2016 Category: Biochemistry Authors: Mayara Oliveira, Ana Georgina Gomes ‐Alves, Carla Sousa, Mariela Mirta Marani, Alexandra Plácido, Nuno Vale, Cristina Delerue‐Matos, Paula Gameiro, Selma A. S. Kückelhaus, Ana M. Tomas, José Roberto S. A. Leite, Peter Eaton Tags: Article Source Type: research
Volume 105, Number 12, December 2016 Table of Contents
(Source: Biopolymers)
Source: Biopolymers - September 21, 2016 Category: Biochemistry Tags: Volume 105, Number 12, December 2016 Table of Contents Source Type: research
Cover Image
(Source: Biopolymers)
Source: Biopolymers - September 21, 2016 Category: Biochemistry Tags: Cover Image Source Type: research
Solution and solid state conformational preferences of a family of cyclic disulphide bridged tetrapeptides
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - September 9, 2016 Category: Biochemistry Authors: Nadja Berger, Fee Li, Bert Mallick, J. Thomas Br üggemann, Wolfram Sander, Christian Merten Tags: Original Article Source Type: research
An Ionic ‐Chemical‐Mechanical Model for Muscle Contraction
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - September 7, 2016 Category: Biochemistry Authors: G. S. Manning Tags: Original Article Source Type: research
Effect of polyamines on mechanical and structural properties of Bombyx mori silk
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - September 5, 2016 Category: Biochemistry Authors: Aparna Yerra, Danti Kumari Mysarla, Prasanthi Siripurapu, Anjali Jha, Satyavathi V Valluri, Anitha Mamillapalli Tags: Original Article Source Type: research
Morphological and transport characteristics of swollen chitosan ‐based proton exchange membranes studied by molecular modeling
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - September 3, 2016 Category: Biochemistry Authors: Ghasem Bahlakeh, Mohammad Mahdi Hasani ‐Sadrabadi, Karl I. Jacob Tags: Original Article Source Type: research
Heparin's Solution Structure Determined by Small ‐Angle Neutron Scattering (SANS)
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - August 20, 2016 Category: Biochemistry Authors: Kenneth A. Rubinson, Yin Chen, Brady F. Cress, Fuming Zhang, Robert J. Linhardt Tags: Original Article Source Type: research
Volume 105, Number 11, November 2016
(Source: Biopolymers)
Source: Biopolymers - August 17, 2016 Category: Biochemistry Tags: Volume 105, Number 11, November 2016 Source Type: research
Biofunctionalizing nanofibers with carbohydrate blood group antigens
Abstract
A rapid and simple method of biofunctionalising nylon, cellulose acetate, and polyvinyl butyral electrospun nanofibers with blood group glycans was achieved by preparing function‐spacer‐lipid constructs and simply contacting them to fibers with a piezo inkjet printer. A series of water dispersible amphipathic glycan‐spacer constructs were synthesized representing a range ABO and related blood group antigens. After immediate contact of the amphipathic glycan‐spacer constructs with nanofiber surfaces they self‐assembled and were detectable by enzyme immunoassays with high sensitivity and specificity. (Source: Biopolymers)
Source: Biopolymers - August 17, 2016 Category: Biochemistry Authors: Katie Barr, Bhuvaneswari Kannan, Elena Korchagina, Inna Popova, Ivan Ryzhov, Stephen Henry, Nicolai Bovin Tags: Article Source Type: research
Volume 105, Number 10, October 2016 Table of Contents
(Source: Biopolymers)
Source: Biopolymers - August 17, 2016 Category: Biochemistry Tags: Volume 105, Number 11, November 2016 Table of Contents Source Type: research
Cover Image
(Source: Biopolymers)
Source: Biopolymers - August 17, 2016 Category: Biochemistry Tags: Cover Image Source Type: research
Effect of DNA on the Conformational Dynamics of the Endonucleases I ‐DmoI as provided by molecular dynamics simulations
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - August 10, 2016 Category: Biochemistry Authors: Alessandro Grottesi, Simone Cecconi, Rafael Molina, Marco D'Abramo Tags: Original Article Source Type: research
