Invited review: Activation of G proteins by GTP and the mechanism of Gα‐catalyzed GTP hydrolysis
ABSTRACT
This review addresses the regulatory consequences of the binding of GTP to the alpha subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis catalyzed by Gα and the means by which GTPase activating proteins (GAPs) stimulate the GTPase activity of Gα. The high energy of GTP binding is used to restrain and stabilize the conformation of the Gα switch segments, particularly switch II, to afford stable complementary to the surfaces of Gα effectors, while excluding interaction with Gβγ, the regulatory binding partner of GDP‐bound Gα. Upon GTP hydrolysis, the energy of these conform...
Source: Biopolymers - May 19, 2016 Category: Biochemistry Authors: Stephen R. Sprang Tags: Article Source Type: research
Invited review: Small GTPases and their GAPs
ABSTRACT
Widespread utilization of small GTPases as major regulatory hubs in many different biological systems derives from a conserved conformational switch mechanism that facilitates cycling between GTP‐bound active and GDP‐bound inactive states under control of guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), which accelerate slow intrinsic rates of activation by nucleotide exchange and deactivation by GTP hydrolysis, respectively. Here we review developments leading to current understanding of intrinsic and GAP catalyzed GTP hydrolytic reactions in small GTPases from structural, mol...
Source: Biopolymers - May 19, 2016 Category: Biochemistry Authors: Ashwini K. Mishra, David G. Lambright Tags: Article Source Type: research
Review: Ras GTPases and myosin: Qualitative conservation and quantitative diversification in signal and energy transduction
ABSTRACT
Most GTPases and many ATPases belong to the P‐loop class of proteins with significant structural and mechanistic similarities. Here we compare and contrast the basic properties of the Ras family GTPases and myosin, and conclude that there are fundamental similarities but also distinct differences related to their specific roles. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 422–430, 2016. (Source: Biopolymers)
Source: Biopolymers - May 19, 2016 Category: Biochemistry Authors: Matthias P. Mueller, Roger S. Goody Tags: Article Source Type: research
Volume 105, Number 8, August 2016 Table of Contents
(Source: Biopolymers)
Source: Biopolymers - May 19, 2016 Category: Biochemistry Tags: Volume 105, Number 8, August 2016 Table of Contents Source Type: research
Cover Image
(Source: Biopolymers)
Source: Biopolymers - May 19, 2016 Category: Biochemistry Tags: Cover Image Source Type: research
Effect of acidic pH on the stability of α−Synuclein dimers
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - May 14, 2016 Category: Biochemistry Authors: Zhengjian Lv, Alexey V. Krasnoslobodtsev, Yuliang Zhang, Daniel Ysselstein, Jean‐Christophe Rochet, Scott C. Blanchard, Yuri L. Lyubchenko Tags: Original Article Source Type: research
Improved model of hydrated calcium ion for molecular dynamics simulations using classical biomolecular force fields
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - May 4, 2016 Category: Biochemistry Authors: Jejoong Yoo, James Wilson, Aleksei Aksimentiev Tags: Original Article Source Type: research
GTP and ATP hydrolysis in Biology
(Source: Biopolymers)
Source: Biopolymers - May 2, 2016 Category: Biochemistry Authors: Alfred Wittinghofer Tags: Editorial Source Type: research
Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto‐phosphorylation site in the histidine kinase CpxA
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - April 29, 2016 Category: Biochemistry Authors: Marlet Martinez, Nathalie Duclert‐Savatier, Jean‐Michel Betton, Pedro M Alzari, Michael Nilges, Thérèse E Malliavin Tags: Original Article Source Type: research
Propensities of peptides containing the Asn‐Gly segment to form β‐turn and β‐hairpin structures
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Source: Biopolymers - April 28, 2016 Category: Biochemistry Authors: Young Kee Kang, In Kee Yoo Tags: Original Article Source Type: research
Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto ‐phosphorylation site in the histidine kinase CpxA
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - April 27, 2016 Category: Biochemistry Authors: Marlet Martinez, Nathalie Duclert ‐Savatier, Jean‐Michel Betton, Pedro M Alzari, Michael Nilges, Thérèse E Malliavin Tags: Original Article Source Type: research
Novel materials based on DNA‐CTMA and lanthanide (Ce3+, Pr3+)
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Source: Biopolymers - April 27, 2016 Category: Biochemistry Authors: Cosmina Andreea Lazar, François Kajzar, Maria Mihaly, Adina Elena Rogozea, Adina Roxana Petcu, Nicoleta Liliana Olteanu, Ileana Rau Tags: Rapid Communication Source Type: research
Molecular crowding impacts the structure of apolipoprotein A ‐I with potential implications on in vivo metabolism and function
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Source: Biopolymers - April 26, 2016 Category: Biochemistry Authors: Jitka Petrlova, Silvia Hilt, Madhu Budamagunta, Joan Domingo ‐Espín, John C Voss, Jens O Lagerstedt Tags: Original Article Source Type: research
Molecular crowding impacts the structure of apolipoprotein A‐I with potential implications on in vivo metabolism and function
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - April 26, 2016 Category: Biochemistry Authors: Jitka Petrlova, Silvia Hilt, Madhu Budamagunta, Joan Domingo‐Espín, John C Voss, Jens O Lagerstedt Tags: Original Article Source Type: research
Mechanochemistry of the kinesin‐1 ATPase
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Source: Biopolymers - April 26, 2016 Category: Biochemistry Authors: R.A. Cross Tags: Review Source Type: research
