Biochimica et Biophysica Acta (BBA) Reviews on Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rethinking pulmonary toxicity in advanced non-small cell lung Cancer in the era of combining anti-PD-1/PD-L1 therapy with thoracic radiotherapy
Publication date: Available online 28 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Mengqian Li, Limei Yin, Andrew Song, Jianxin Xue, You LuAbstractThe combination of programmed cell death 1/programmed cell death ligand 1 blockade and thoracic radiotherapy has become the new standard of care in the treatment of locally advanced non-small-cell lung cancer. The information regarding the pulmonary safety of such therapy remains limited to mostly retrospective studies and case reports with a small portion of data from prospective clinical trials. By analyzing the underlying mechanisms o...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 1, 2019 Category: Cancer & Oncology Source Type: research

Many ways to resistance: How melanoma cells evade targeted therapies
Publication date: Available online 15 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ines Kozar, Christiane Margue, Sonja Rothengatter, Claude Haan, Stephanie KreisAbstractMelanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 16, 2019 Category: Cancer & Oncology Source Type: research

RLIP: An existential requirement for breast carcinogenesis
Publication date: Available online 13 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sharad S. Singhal, Ravi Salgia, Sulabh Singhal, David Horne, Sanjay AwasthiAbstractBreast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 14, 2019 Category: Cancer & Oncology Source Type: research

Reflections on depletion of tumor stroma in pancreatic cancer
Publication date: Available online 6 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wen-Quan Wang, Liang Liu, Jin-Zhi Xu, Xian-Jun YuAbstractPancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: research

Recent advances in extracellular vesicle research for urological cancers: from technology to application
Publication date: Available online 7 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Liang Dong, Richard C. Zieren, Yanqing Wang, Theo M. de Reijke, Wei Xue, Kenneth J. PientaAbstractUrological malignancies, including prostate cancer, bladder cancer and kidney cancer are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: research

The role of necroptosis in cancer: A double-edged sword?
Publication date: Available online 1 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xia Qin, Dan Ma, Ye-xiong Tan, Hong-yang Wang, Zhenyu CaiAbstractNecroptosis is a programmed, caspase-independent cell death that is morphologically similar to necrosis. Unlike apoptosis, necroptosis evokes inflammatory responses by releasing damage-associated molecular patterns. Recent studies suggest that tumor undergoes necroptosis in vivo and necroptosis has pro- or anti-tumoral effects in cancer development and progression. Furthermore, triggering necroptosis in tumor cells has been explored as a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - February 2, 2019 Category: Cancer & Oncology Source Type: research

A critical review of the role of M2PYK in the Warburg effect
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Robert A. Harris, Aron W. FentonAbstractIt is becoming generally accepted in recent literature that the Warburg effect in cancer depends on inhibition of M2PYK, the pyruvate kinase isozyme most commonly expressed in tumors. We remain skeptical. There continues to be a general lack of solid experimental evidence for the underlying idea that a bottle neck in aerobic glycolysis at the level of M2PYK results in an expanded pool of glycolytic intermediates (which are thought to serve as building blocks nec...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Prostate Cancer-specific Hallmarks of Amino Acids Metabolism: Towards a Paradigm of Precision Medicine
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Vladislav Strmiska, Petr Michalek, Tomas Eckschlager, Marie Stiborova, Vojtech Adam, Sona Krizkova, Zbynek HegerAbstractSo far multiple differences in prostate cancer-specific amino acids metabolism have been discovered. Moreover, some attempts to utilize these alterations for prostate cancer diagnosis and treatment have been made. The prostate cancer metabolism and biosynthesis of amino acids are particularly focused on anaplerosis more than on energy production. Other crucial requirements on amino a...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Targeting acidity in cancer and diabetes
Publication date: Available online 30 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Robert J. Gillies, Christian Pilot, Yoshinori Marunaka, Stefano FaisAbstractWhile cancer is commonly described as “a disease of the genes”, it is also a disease of metabolism. Indeed, carcinogenesis and malignancy are highly associated with metabolic re-programming, and there is clinical evidence that interrupting a cancer's metabolic program can improve patients' outcomes. Notably, many of the metabolic adaptations observed in cancer are similar to the same perturbations observed in diabetic pati...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Combination therapies with HSP90 inhibitors against colorectal cancer
Publication date: Available online 30 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Kushtrim Kryeziu, Jarle Bruun, Tormod K. Guren, Anita Sveen, Ragnhild A. LotheAbstractOncogene stability and homeostasis mediated by the HSP90 chaperone is a crucial protection trait of cancer cells. Therefore, HSP90 represents an attractive therapeutic target for many cancers, including colorectal cancer. Although monotherapy has limited clinical efficacy, preclinical and early-phase clinical studies indicate improved antitumor activity when HSP90 inhibitors are combined with chemotherapies or target...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 30, 2019 Category: Cancer & Oncology Source Type: research

Potential Roles and Targeted Therapy of the CXCLs/CXCR2 Axis in Cancer and Inflammatory Diseases
Publication date: Available online 29 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yuan Cheng, Xue-lei Ma, Yu-quan Wei, Xia-Wei WeiAbstractThe chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple signalling pathways, including the PI3K, p38/ERK, and JAK pathways, and regulates cell survival and migration. The CXCLs/CXCR2 axis plays a vital role in the tumour microenvironment and in recruiting neutrophils to inflammatory sites. Extensive infiltration of neutrophil...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 29, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 23, 2019 Category: Cancer & Oncology Source Type: research

The expression of FOXP3 and its role in human cancers
Publication date: Available online 7 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Hao Jia, Haolong Qi, Zhongqin Gong, Shucai Yang, Jianwei Ren, Yi Liu, Mingyue Li, George Gong ChenAbstractFOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was initially discovered in regulatory T cells and supposed to play a significant role in the process of regulatory T cell differentiation. Increasing evidence has shown that FOXP3 is also expressed in tumor cells. However, the results of tumor FOXP3 is inconsistent and even the opposite. In some types of human cance...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 8, 2019 Category: Cancer & Oncology Source Type: research

Targeting mitosis exit: A brake for cancer cell proliferation
Publication date: Available online 3 January 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xinran Liu, Yuchen Chen, Yangkai Li, Robert B. Petersen, Kun HuangAbstractThe transition from mitosis to interphase, referred to as mitotic exit, is a critical mitotic process which involves activation and inactivation of multiple mitotic kinases and counteracting protein phosphatases. Loss of mitotic exit checkpoints is a common feature of cancer cells, leading to mitotic dysregulation and confers cancer cells with oncogenic characteristics, such as aberrant proliferation and microtubule-targeting age...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2019 Category: Cancer & Oncology Source Type: research

Immune checkpoint blockade and its combination therapy with small-molecule inhibitors for cancer treatment
Publication date: Available online 31 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wang Manni, Yu Liu, Yuan Cheng, Wei Xiawei, Wei YuquanAbstractInitially understood for its physiological maintenance of self-tolerance, the immune checkpoint molecule has recently been recognized as a promising anti-cancer target. There has been considerable interest in the biology and the action mechanism of the immune checkpoint therapy, and their incorporation with other therapeutic regimens. Recently the small-molecule inhibitor (SMI) has been identified as an attractive combination partner for i...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 1, 2019 Category: Cancer & Oncology Source Type: research