Biochimica et Biophysica Acta (BBA) Reviews on Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Sodium homeostasis in the tumour microenvironment
Publication date: Available online 23 July 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Theresa K. Leslie, Andrew D. James, Fulvio Zaccagna, James T. Grist, Surrin Deen, Aneurin Kennerley, Frank Riemer, Joshua D. Kaggie, Ferdia A. Gallagher, Fiona J. Gilbert, William J. BrackenburyAbstractThe concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 24, 2019 Category: Cancer & Oncology Source Type: research

Novel insights into breast cancer progression and metastasis: A multidisciplinary opportunity to transition from biology to clinical oncology
Publication date: Available online 23 July 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Manuel Scimeca, Nicoletta Urbano, Rita Bonfiglio, Andrea Duggento, Nicola Toschi, Orazio Schillaci, Elena BonannoAbstractAccording to the most recent epidemiological studies, breast cancer shows the highest incidence and the second leading cause of death in women. Cancer progression and metastasis are the main events related to poor survival of breast cancer patients. This can be explained by the presence of highly resistant to chemo- and radiotherapy stem cells in many breast tumor tissues. In this cont...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - July 24, 2019 Category: Cancer & Oncology Source Type: research

Comprehensive elaboration of database resources utilized in next-generation sequencing-based tumor somatic mutation detection
Publication date: Available online 29 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Peng Gao, Rui Zhang, Jinming LiAbstractThe rapid evolution of next-generation sequencing (NGS)-based tumor genomic profile detection and the emergence of molecularly targeted therapies have enabled precision oncology. In NGS-based analysis, various types of databases have been developed to perform different functions. However, many problems still exist when using these public databases. Therefore, it is important to better understand the characteristics and limitations of each database and have them comp...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 30, 2019 Category: Cancer & Oncology Source Type: research

Fibroblasts in cancer: Defining target structures for therapeutic intervention
This article summarizes the various levels at which the fibroblastic tumor stroma may impact cancer progression and highlights potential target structures for future therapeutic intervention(s). (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 30, 2019 Category: Cancer & Oncology Source Type: research

Metastasis as a systemic disease: molecular insights and clinical implications
Publication date: Available online 14 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maša Alečković, Sandra S. McAllister, Kornelia PolyakAbstractMetastasis is a complex systemic disease that develops as a result of interactions between tumor cells and their local and distant microenvironments. Local and systemic immune-related changes play especially critical roles in limiting or enabling the development of metastatic disease. Although anti-tumor immune responses likely eliminate most early primary and metastatic lesions, factors secreted by cancer or stromal cells in the primary tum...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 14, 2019 Category: Cancer & Oncology Source Type: research

FLT3 overexpression in acute leukaemias: New insights into the search for molecular mechanisms
Publication date: Available online 12 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Caroline Pires Poubel, Marcela B. Mansur, Mariana Boroni, Mariana EmerencianoAbstractFLT3 overexpression is a recurrent event in various acute leukaemia subtypes. This transcriptional deregulation is important to define the prognostic risk for many patients. Of note, the molecular mechanisms leading to this gene upregulation are unknown for a substantial number of cases. In this Mini-Review, we highlight the role of FLT3 overexpression in acute leukaemia and discuss emerging mechanisms accounting for thi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 13, 2019 Category: Cancer & Oncology Source Type: research

Bacterial biofilms as a potential contributor to mucinous colorectal cancer formation
Publication date: Available online 12 June 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Shan Li, Maikel P. Peppelenbosch, Ron SmitsAbstractA prominent mucinous phenotype is observed in 10–15% of all colorectal cancers (CRCs). They are associated with a proximal location, and more commonly observed among tumors with mismatch repair defects and a promoter CpG methylator phenotype. However, none of these features has been clearly linked mechanistically to this mucinous subtype. Here, we propose that bacterial biofilms could represent a currently unappreciated contributor to mucinous CRC form...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - June 12, 2019 Category: Cancer & Oncology Source Type: research

Defective mitosis-linked DNA damage response and chromosomal instability in liver cancer
Publication date: Available online 29 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maryam Tahmasebi Birgani, Hossein Ansari, Vinicio CarloniAbstractHepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

Clinical validity of saliva and novel technology for cancer detection
Publication date: Available online 30 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Karolina Elżbieta Kaczor-Urbanowicz, Fang Wei, Shannon Liu Rao, Jinseok Kim, Heebum Shin, Jordan Cheng, Michael Tu, David T.W. Wong, Yong KimAbstractCancer, a local disease at an early stage, systemically evolves as it progresses by triggering alterations in surrounding microenvironment, disturbing immune surveillance and further disseminating its molecular contents into circulation. This pathogenic characteristic of cancer makes the use of biofluids such as blood/serum/plasma, urine, tear and cerebrospi...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway?
Publication date: Available online 30 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Gabriele Grasmann, Elisabeth Smolle, Horst Olschewski, Katharina LeithnerAbstractCancer cells constantly face a fluctuating nutrient supply and interference with adaptive responses might be an effective therapeutic approach. It has been discovered that in the absence of glucose, cancer cells can synthesize crucial metabolites by expressing phosphoenolpyruvate carboxykinase (PEPCK, PCK1 or PCK2) using abbreviated forms of gluconeogenesis. Gluconeogenesis, which in essence is the reverse pathway of glycolys...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

Divergent roles of Plexin D1 in Cancer
Publication date: Available online 30 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sneha Vivekanandhan, Debabrata MukhopadhyayAbstractPlexin D1 belongs to a family of transmembrane proteins called plexins. It was characterized as a receptor for semaphorins and is known to be essential for axonal guidance and vascular patterning. Mutations in Plexin D1 have been implicated in pathologic conditions such as truncus arteriosus and Möbius syndrome. Emerging data show that expression of Plexin D1 is deregulated in several cancers; it can support tumor development by aiding tumor angiogenesis...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

From genetics to signaling pathways: molecular pathogenesis of esophageal adenocarcinoma
Publication date: Available online 30 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ravindran Caspa Gokulan, Monica T. Garcia-Buitrago, Alexander I. ZaikaAbstractEsophageal adenocarcinoma (EAC) has one of the fastest rising incidence rates in the U.S. and many other Western countries. One of the unique risk factors for EAC is gastroesophageal reflux disease (GERD), a chronic digestive condition in which acidic contents from the stomach, frequently mixed with duodenal bile, enter the esophagus resulting in esophageal tissue injury. At the cellular level, progression to EAC is underlined b...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

Neuroendocrine regulation of cholangiocarcinoma: A status quo review
Publication date: Available online 30 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Meng Sha, Jie Cao, Han-yong Sun, Ying Tong, Qiang XiaAbstractIncreasing studies have demonstrated that neuroendocrine system is involved in the development and progression of cholangiocarcinoma. The neuroendocrine hormones, neurotransmitters and neuropeptides regulate cholangiocarcinoma via affecting pathophysiology of tumor cells. The developing interaction and interplay between neuroendocrine-associated factors and tumor cells provide novel insights into neural control of tumorigenesis and reveal potent...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 30, 2019 Category: Cancer & Oncology Source Type: research

Corrigendum to Preclinical models for precision oncology. BBACAN 1870/2 (2018) 239–246
Publication date: Available online 25 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maider Ibarrola-Villava, Andrés Cervantes, Alberto Bardelli (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 26, 2019 Category: Cancer & Oncology Source Type: research

The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection
Publication date: August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1872, Issue 1Author(s): Cheng-Bei Zhou, Jing-Yuan FangAbstractPyroptosis, a type of inflammatory programmed cell death, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β2. It can induce cancer cell death within the gastrointestinal tract. NLRs3, AIM24, GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, e...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 23, 2019 Category: Cancer & Oncology Source Type: research