Biochimica et Biophysica Acta (BBA) Reviews on Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Editorial Board
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 17, 2020 Category: Cancer & Oncology Source Type: research

Multiple roles and context-specific mechanisms underlying YAP and TAZ-mediated resistance to anti-cancer therapy
Publication date: Available online 10 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi, Davide Carlo Ambrosetti, Valentina SancisiAbstractUnderstanding the molecular mechanisms driving resistance to anti-cancer drugs is both a crucial step to define markers of response to therapy and a clinical need in many cancer settings. YAP and TAZ transcriptional cofactors behave as oncogenes in different cancer types. Deregulation of YAP/TAZ expression or alterations in components of the multiple signaling pathways converging on these factors ar...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 11, 2020 Category: Cancer & Oncology Source Type: research

Communication in tiny packages: Exosomes as means of tumor-stroma communication
Publication date: Available online 8 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Juliane Daßler-Plenker, Victoria Küttner, Mikala EgebladAbstractTumor-derived exosomes are nano-sized vesicles acting as multi-signal devices influencing tumor growth at local and distant sites. Exosomes are derived from the endolysosomal compartment and can shuttle diverse biomolecules like nucleic acids (microRNAs, DNA fragments), lipids, proteins and even pharmacological compounds from a donor cell to recipient cells. The transfer of cargo to recipient cells enables tumor-derived exosomes to influ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 9, 2020 Category: Cancer & Oncology Source Type: research

BRCA1/P53: Two strengths in cancer chemoprevention
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Liliana Raimundo, Helena Ramos, Joana B. Loureiro, Juliana Calheiros, Lucília SaraivaAbstractIncreasing emphasis has been given to prevention as a feasible approach to reduce the cancer burden. However, for its clinical success, further advances are required to identify effective chemopreventive agents. This review affords a critical and up-to-date discussion of issues related to cancer prevention, including an in-depth knowledge on BRCA1 and p53 tumor suppressor proteins as key molecular players. Ind...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 7, 2020 Category: Cancer & Oncology Source Type: research

The emerging role of paraptosis in tumor cell biology: Perspectives for cancer prevention and therapy with natural compounds
Publication date: Available online 3 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Fabrizio Fontana, Michela Raimondi, Monica Marzagalli, Alessandro Di Domizio, Patrizia LimontaAbstractStandard anti-cancer therapies promote tumor growth suppression via induction of apoptosis. However, in most cases cancer cells acquire the ability to escape apoptotic cell death, thus becoming resistant to current treatments. In this setting, the interest in alternative cell death modes has recently increased. Paraptosis is a new form of programmed cell death displaying endoplasmic reticulum (ER) and/...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2020 Category: Cancer & Oncology Source Type: research

RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis
Publication date: Available online 2 January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sharad S. Singhal, Ravi Salgia, Nisan Verma, David Horne, Sanjay AwasthiAbstractRLIP (Ral-interacting protein) is a multifunctional protein that couples ATP hydrolysis with the movement of substances. Its primary function appears to be in the plasma membrane, where it catalyzes the ATP-dependent efflux of glutathione-conjugates (GS-Es), as well as un-metabolized drugs and toxins. In the plasma membrane, its interaction with the clathrin adaptor protein AP2 localizes it to endocytic vesicle, where its G...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - January 4, 2020 Category: Cancer & Oncology Source Type: research

The conflicting role of E2F1 in prostate cancer: A matter of cell context or interpretational flexibility?
Publication date: Available online 21 December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Jung Nyeo Chun, Minsoo Cho, Soonbum Park, Insuk So, Ju-Hong JeonAbstractThe transcription factor E2F1 plays a crucial role in mediating multiple cancer hallmark capabilities that regulate cell cycle, survival, apoptosis, metabolism, and metastasis. Aberrant activation of E2F1 is closely associated with a poor clinical outcome in various human cancers. However, E2F1 has conflictingly been reported to exert tumor suppressive activity, raising a question as to the nature of its substantive role in the c...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 22, 2019 Category: Cancer & Oncology Source Type: research

The role of AhR in transcriptional regulation of immune cell development and function
Publication date: Available online 6 December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Prashant Trikha, Dean A. LeeAbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including malignant transformation, hematopoietic cell development, and fate determination of immune cell lineages. Moreover, AhR forms a crucial link between innate and adaptive arms of the immune system. Malignant cells frequently evolve multiple mechanisms for suppressing tumor-specific res...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - December 7, 2019 Category: Cancer & Oncology Source Type: research

Mechanism of colorectal carcinogenesis triggered by heme iron from red meat
Publication date: Available online 26 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Nina Seiwert, Daniel Heylmann, Solveig Hasselwander, Jörg FahrerAbstractColorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing incidence in younger people CRC formation is causally linked to various genetic, life-style and dietary risk factors. Among the ladder, the consumption of red meat has emerged as important risk factor contributing to CRC. A large body of evidence shows that heme iron is the critical component of red meat, which promotes colorectal carcinogen...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 26, 2019 Category: Cancer & Oncology Source Type: research

Principles and methods of integrative chromatin analysis in primary tissues and tumors
Publication date: Available online 22 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Paloma Cejas, Henry W. LongAbstractRecent methodological advances have enabled the genome-wide interrogation of chromatin from primary tumor tissues. Integrative analysis of histone post-translational modifications, transcription factor (TF) binding and open chromatin sites in tumors across cancer stages can elucidate the aberrant epigenetic states accompanying tumor progression. Cancer-associated chromatin alterations can activate or inactivate enhancers at genes involved in cancer while still respe...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 23, 2019 Category: Cancer & Oncology Source Type: research

Targeting citrate as a novel therapeutic strategy in cancer treatment
Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lan Huang, Cindy Wang, Huaxi Xu, Guangyong PengAbstractAn important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. The distinctly reprogrammed metabolism in cancer cells makes it possible to manipulate the levels of metabolites for cancer treatment. Citrate is a key metabolite that bridges many important metabolic pathways. Recent studies indicate that manipulating the level of citrate can impact the behaviors of both cancer ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 20, 2019 Category: Cancer & Oncology Source Type: research

The intricate relationship between diabetes, obesity and pancreatic cancer
Publication date: Available online 9 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Silvano Paternoster, Marco FalascaAbstractPancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the m...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 9, 2019 Category: Cancer & Oncology Source Type: research

Venous thromboembolism GWAS reported genetic makeup and the hallmarks of cancer: Linkage to ovarian tumour behaviour
Publication date: Available online 2 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Valéria Tavares, Ricardo Pinto, Joana Assis, Deolinda Pereira, Rui MedeirosAbstractVenous thromboembolism (VTE) is a common cardiovascular disease thought to be the outcome of an intricate interplay between acquired and inherited factors that act together to modify disease risk. Over the years, several single-nucleotide polymorphisms (SNPs) in candidate genes have been associated with disease risk, including F5 rs6025, F2 rs1799963, FGG rs2066865, ABO genetic variants, among others less common. More ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 3, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: December 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1872, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 2, 2019 Category: Cancer & Oncology Source Type: research

Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 1Author(s): Subash C. Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B. ChallagundlaAbstractThe regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANR...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 2, 2019 Category: Cancer & Oncology Source Type: research