Biochimica et Biophysica Acta (BBA) Reviews on Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Lipoic acid a multi-level molecular inhibitor of tumorigenesis
Publication date: January 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1873, Issue 1Author(s): D. Farhat, H. LincetAbstractWe discuss how lipoic acid (LA), a natural antioxidant, induces apoptosis and inhibits proliferation, EMT, metastasis and stemness of cancer cells. Furthermore, owing to its ability to reduce chemotherapy-induced side effects and chemoresistance, LA appears to be a promising compound for cancer treatment. (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 2, 2019 Category: Cancer & Oncology Source Type: research

Challenges in liver cancer and possible treatment approaches
Publication date: Available online 1 November 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): David Anwanwan, Santosh Kumar Singh, Shriti Singh, Varma Saikam, Rajesh SinghAbstractGlobally, liver cancer is the most frequent fatal malignancy; in the United States, it ranks fifth. Patients are often diagnosed with liver cancer in advanced stages, contributing to its poor prognosis. Of all liver cancer cases,>90% are hepatocellular carcinomas (HCCs) for which chemotherapy and immunotherapy are the best options for therapy. For liver cancer patients, new treatment options are necessary. Use of natu...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - November 1, 2019 Category: Cancer & Oncology Source Type: research

Elevating pancreatic cystic lesion stratification: Current and future pancreatic cancer biomarker(s)
Publication date: Available online 30 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Joseph Carmicheal, Asish Patel, Vipin Dalal, Pranita Atri, Amaninder S. Dhaliwal, Uwe A. Wittel, Mokenge P. Malafa, Geoffrey Talmon, Benjamin J. Swanson, Shailender Singh, Maneesh Jain, Sukhwinder Kaur, Surinder K. BatraAbstractPancreatic ductal adenocarcinoma (PDAC) is an incredibly deadly disease with a 5-year survival rate of 6%. The presence of pancreatic cystic lesions (PCLs) confers an increased likelihood of future pancreatic cancer in patients placing them in a high-risk category. Discerning c...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 31, 2019 Category: Cancer & Oncology Source Type: research

Harnessing the therapeutic potential of anticancer drugs through amorphous solid dispersions
Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Urvi H. Gala, Dave A. Miller, Robert O. WilliamsAbstractThe treatment of cancer is still a major challenge. But tremendous progress in anticancer drug discovery and development has occurred in the last few decades. However, this progress has resulted in few effective oncology products due to challenges associated with anticancer drug delivery. Oral administration is the most preferred route for anticancer drug delivery, but the majority of anticancer drugs currently in product pipelines and the majori...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 31, 2019 Category: Cancer & Oncology Source Type: research

The association between type of endocrine therapy and development of estrogen receptor-1 mutation(s) in patients with hormone-sensitive advanced breast cancer: A systematic review and meta-analysis of randomized and non-randomized trials
ConclusionESR1 mutations are not uncommon phenomenon in patients with hormone-sensitive advanced breast cancer. There is a significant higher incidence rate of ESR1 mutations in patients with previous AI-containing therapeutic regimens, compared to those who received non-AI containing regimes. These ESR1 mutations could lead to the development of complete endocrine resistance to AI, whereas only partial resistance is seen in case of TAM or FUL. (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 22, 2019 Category: Cancer & Oncology Source Type: research

Nervous system and gastric cancer
Publication date: Available online 21 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ke Wang, Xin-hui Zhao, Jun Liu, Rui Zhang, Ji-peng LiAbstractThe nervous system has been recently shown to exert impact on gastric cancer directly and indirectly. Gastric cancer cells invade nerve fibers to induce outgrowth and branching of neural cells, and nerve fibers in turn infiltrate into tumor microenvironment to promote progression of gastric cancer. Additionally, the neuro-immune interaction also plays an important role in gastric cancer development. The interplay of nerves and gastric cancer...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 22, 2019 Category: Cancer & Oncology Source Type: research

Long non-coding RNAs and nuclear factor-B crosstalk in cancer and other human diseases
Publication date: Available online 19 October 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Subash C. Gupta, Nikee Awasthee, Vipin Rai, Srinivas Chava, Venugopal Gunda, Kishore B. ChallagundlaAbstractThe regulation of the pleiotropic transcription factor, nuclear factor-κB (NF-κB) by miRNAs and proteins is extensively studied. More recently, the NF-κB signaling was also reported to be regulated by several long non-coding RNAs (lncRNAs) that constitute the major portion of the noncoding component of the human genome. The common NF-κB associated lncRNAs include NKILA, HOTAIR, MALAT1, ANRIL...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - October 20, 2019 Category: Cancer & Oncology Source Type: research

Functional analysis of deubiquitylating enzymes in tumorigenesis and development
Publication date: Available online 23 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Ji Cheng, Jianping Guo, Brian J. North, Bin Wang, Chun-Ping Cui, Hongchang Li, Kaixiong Tao, Lingqiang Zhang, Wenyi WeiAbstractDeubiquitylating enzymes (DUBs) are proteases that remove the ubiquitin moiety from ubiquitylated substrates to antagonize the modification mediated by E3 ubiquitin ligases. Currently, DUBs have been found to play critical roles in the regulation of various physiological or pathological processes, such as embryogenesis, immune homeostasis, tumorigenesis and neurodegenerative di...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 24, 2019 Category: Cancer & Oncology Source Type: research

The tumor immune microenvironment in gastroenteropancreatic neuroendocrine neoplasms
Publication date: Available online 20 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wu-Hu Zhang, Wen-Quan Wang, He-Li Gao, Xian-Jun Yu, Liang LiuAbstractGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of rare tumors that are increasing in prevalence. The complex tumor immune microenvironment (TIME) plays an important role in tumor development and the response to immunotherapy but is poorly understood. In this review, the components of the TIME are described in detail, including discussion about infiltrating immune cells, the immune checkpoint system, the cytokin...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 21, 2019 Category: Cancer & Oncology Source Type: research

Mechanisms of acquired tumor drug resistance
Publication date: Available online 20 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Svetlana N. Aleksakhina, Aniruddh Kashyap, Evgeny N. ImyanitovAbstractSystemic therapy often results in the reduction of tumor size but rarely succeeds in eradicating all cancer cells. Drug efflux, persistence of cancer stem cells (CSCs), epithelial-mesenchymal transition (EMT) and down-regulation of apoptosis are the most known general causes of therapy failure. Tumor escape from targeted compounds often involves pathway-specific mechanisms, which result in the restoration of the affected signaling ca...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 21, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1872, Issue 1Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 10, 2019 Category: Cancer & Oncology Source Type: research

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity
Publication date: Available online 8 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Claire Donohoe, Mathias O. Senge, Luís G. Arnaut, Lígia C. Gomes-da-SilvaAbstractPhotodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. The generated oxidative stress may activate multiple mechanism of cell death which are counteracted by cells through adaptive stress responses that target homeostasis rescue. The present renaissance of PDT was leveraged by the acknowledgment that this therapy has an immed...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 9, 2019 Category: Cancer & Oncology Source Type: research

From squamous intraepithelial lesions to cervical cancer: Circulating microRNAs as potential biomarkers in cervical carcinogenesis
Publication date: Available online 6 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Fernanda Costa Brandão Berti, Amanda Salviano-Silva, Helen Cristina Beckert, Karen Brajão de Oliveira, Gabriel Adelman Cipolla, Danielle MalheirosAbstractDespite Human Papillomavirus (HPV) essential role in cervical carcinogenesis, other factors are required for cancer establishment, like miRNAs. Such molecules present a complex biogenesis, being diversely distributed across tissues and biological fluids, as cell-free miRNAs or miRNAs present in extracellular vesicles (EV). After HPV infection, an int...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 8, 2019 Category: Cancer & Oncology Source Type: research

Microbial carcinogenesis: Lactic acid bacteria in gastric cancer
Publication date: Available online 5 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Karla Vinasco, Hazel M. Mitchell, Nadeem O. Kaakoush, Natalia Castaño-RodríguezAbstractWhile Helicobacter pylori is a fundamental risk factor, gastric cancer (GC) aetiology involves combined effects of microbial (both H. pylori and nonH. pylori), host and environmental factors. Significant differences exist between the gastric microbiome of those with gastritis, intestinal metaplasia and GC, suggesting that dysbiosis in the stomach is dynamic and correlates with progression to GC. Most notably, a cons...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 6, 2019 Category: Cancer & Oncology Source Type: research

Diverse mechanisms of PARP inhibitor resistance in ovarian cancer
Publication date: Available online 2 August 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Matthew John Wakefield, Ksenija Nesic, Olga Kondrashova, Clare L. Scott (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - August 2, 2019 Category: Cancer & Oncology Source Type: research