Biochimica et Biophysica Acta (BBA) Reviews on Cancer This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer
Publication date: Available online 31 December 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Shikha Saini, Ajay V. Maker, Kenneth D. Burman, Bellur S. PrabhakarAbstractAnaplastic Thyroid Cancer (ATC) accounts for>40% thyroid cancer-related deaths and has a dismal prognosis. In the past decade, significant efforts have been made towards understanding the pathogenesis of this disease and developing novel therapeutics. Unfortunately, effective treatment is still lacking and a more thorough understanding of ATC pathogenesis may provide new opportunities to improve ATC therapeutics. This review p...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 18, 2019 Category: Cancer & Oncology Source Type: research

Editorial Board
Publication date: April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 2Author(s): (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 15, 2019 Category: Cancer & Oncology Source Type: research

Achalasia and associated esophageal cancer risk: What lessons can we learn from the molecular analysis of Barrett's–associated adenocarcinoma?
Publication date: Available online 4 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): K. Nesteruk, M.C.W. Spaander, I. Leeuwenburgh, M.P. Peppelenbosch, G.M. FuhlerAbstractIdiopathic achalasia and Barrett's esophagus (BE) are preneoplastic conditions of the esophagus. BE increases the risk of esophageal adenocarcinoma (EAC), while achalasia is associated with both EAC and esophageal squamous cell carcinoma (ESCC). However, while the molecular mechanisms underlying the transformation of esophageal epithelial cells in BE are relatively well characterized, less is known regarding these process...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 4, 2019 Category: Cancer & Oncology Source Type: research

The role of inflammatory programmed cell death in gastrointestinal cancer and immune responses to intestinal microbial infection
Publication date: Available online 3 May 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Cheng-Bei Zhou, Jing-Yuan FangAbstractInflammatory programmed cell death, also called pyroptosis, is mediated by multiple inflammasomes which can recognize danger signals and activate the secretion of pro-inflammatory cytokines like IL-181 and IL-1β.2 It can induce cancer cell death within the gastrointestinal tract. NLRs,3 AIM2,4 GSDM5 family play important roles in pyroptosis signaling pathways in intestinal cancer such as gastric cancer, colitis-associated colorectal cancer and esophageal cancer, etc. ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Exosomes in cancer development, metastasis, and immunity
Publication date: Available online 30 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Lin Zhang, Dihua YuAbstractExosomes play essential roles in intercellular communications. The exosome was discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles carrying transferrin receptors into the extracellular space. Since then, our understanding of the mechanism and function of the exosome has expanded exponentially that has transformed our perspective of inter-cellular exchanges and the molecular mechanisms that underlie disease progression. Cancer cells generally p...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 30, 2019 Category: Cancer & Oncology Source Type: research

The small members of the JMJD protein family: Enzymatic jewels or jinxes?
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sangphil Oh, Sook Shin, Ralf JanknechtAbstractJumonji C domain-containing (JMJD) proteins are mostly epigenetic regulators that demethylate histones. However, a hitherto neglected subfamily of JMJD proteins, evolutionarily distant and characterized by their relatively small molecular weight, exerts different functions by hydroxylating proteins and RNA. Recently, unsuspected proteolytic and tyrosine kinase activities were also ascribed to some of these small JMJD proteins, further increasing their enzyma...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Nanoparticle-mediated targeted drug delivery for breast cancer treatment
In this study, we summarize with a critical analysis of the most recent therapeutic studies involving various NPs-mediated DDS as alternatives for the traditional treatment approaches for BC. It will shed light on the significance of NPs-mediated DDS and serve as a guide to seeking for the ideal methodology for future targeted drug delivery for an efficient BC treatment.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer)
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

The AP-1 transcriptional complex: Local switch or remote command?
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Bejjani Fabienne, Evanno Emilie, Zibara Kazem, Piechaczyk Marc, Jariel-Encontre IsabelleSummaryThe ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all cellular and physiological functions. It is paramount for cells to reprogram gene expression in response to cues of many sorts and is involved in many tumorigenic processes. How AP-1 controls gene transcription has largely remained elusive till recently. The advent of the “omics” technologies permitting genome-wide s...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
Publication date: Available online 26 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Patrycja Nowak-Sliwinska, Leonardo Scapozza, Ariel Ruiz i AltabaAbstractThe strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug repurposing promises faster access of drugs to patients while reducing costs in the long and difficult process of drug development. However, the number of existing drugs and diseases, together with the heterogeneity of patients and diseases, notably including cancers, can make repurp...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer
In conclusion, breast harbors a community of microbes that can communicate with the host cells inducing downstream signaling pathways and modulating various aspects of breast cancer growth and metastatic progression and an improved understanding of microbial dysbiosis can potentially reduce breast cancer risk and improve outcomes of breast cancer patients.The human microbiome, now referred to as, the “forgotten organ” contains a metagenome that is 100-fold more diverse compared to the human genome, thereby, is critically associated with human health [1,2]. With the revelations of the human microbiome project and advent...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 12, 2019 Category: Cancer & Oncology Source Type: research

Targeting the mTOR regulatory network in hepatocellular carcinoma: Are we making headway?
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Xiang-Nan Yu, Hong Chen, Tao-Tao Liu, Jian Wu, Ji-Min Zhu, Xi-Zhong ShenAbstractThe mechanistic target of rapamycin (mTOR) pathway coordinates organismal growth and homeostasis in response to growth factors, nutrients, and cellular energy stage. The pathway regulates several major cellular processes and is implicated in various pathological conditions, including hepatocellular carcinoma (HCC). This review summarizes recent advances of the mTOR pathway, highlights the potential of the mTOR pathway as a th...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 3, 2019 Category: Cancer & Oncology Source Type: research

Atomic force microscopy-based cancer diagnosis by detecting cancer-specific biomolecules and cells
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Taeyun Kwon, Sundaram Gunasekaran, Kilho EomAbstractAtomic force microscopy (AFM) has recently attracted much attention due to its ability to analyze biomolecular interactions and to detect certain biomolecules, which play a crucial role in disease expression. Despite recent studies reporting AFM imaging for the analyses of biomolecules, the application of AFM-based cancer-specific biomolecule/cell detection has remained largely underexplored, especially for the early diagnosis of cancer. In this paper, ...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 3, 2019 Category: Cancer & Oncology Source Type: research

Targeting PI3K signaling in cancer: Challenges and advances
Publication date: Available online 1 April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Maria Chiara De Santis, Federico Gulluni, Carlo Cosimo Campa, Miriam Martini, Emilio HirschAbstractThe key role of phosphoinositide 3-kinase (PI3K) pathway in different cellular processes and several disorders, together with the presence of targetable proteins, opened the way to promising studies for the development of small molecule inhibitors. Despite the high expectation, the shift of PI3K inhibitors to the clinic met several limitations due to the emergence of dose-limiting, on-target adverse effects...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - April 2, 2019 Category: Cancer & Oncology Source Type: research

Pyruvate kinase M2: A multifarious enzyme in non-canonical localization to promote cancer progression
Publication date: April 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1871, Issue 2Author(s): Sajid Amin, Peng Yang, Zhuoyu LiAbstractRewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common signature of cancer cells to meet their high energetic and biosynthetic demands of rapid growth and proliferation. Pyruvate kinase M2 isoform (PKM2) is a key player in such metabolic reshuffle, which functions as a rate-limiting glycolytic enzyme in the cytosol of highly-proliferative cancer cells. During the recent decades, PKM2 has been extensively studied in non-canonical...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 16, 2019 Category: Cancer & Oncology Source Type: research

Non-canonical localization of PKM2 in cancer progression: Mechanism of nuclear translocation
Publication date: Available online 28 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Sajid Amin, Peng Yang, Zhuoyu LiAbstractCancer cells upregulate pyruvate kinase M2 isoform (PKM2) for their imperiously high energetic and biosynthetic demands to achieve enhanced proliferation, a common fingerprint of all type of cancers. PKM2 was primitively discovered as a cytosolic glycolytic enzyme, now has been extensively reported in non-canonical localizations such as extracellular secretion, mitochondrial localization, nuclear translocation, and exclusively pertained to novel biological func...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - March 1, 2019 Category: Cancer & Oncology Source Type: research