Reflections on depletion of tumor stroma in pancreatic cancer

Publication date: Available online 6 February 2019Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Wen-Quan Wang, Liang Liu, Jin-Zhi Xu, Xian-Jun YuAbstractPancreatic cancer characteristically has an extremely dense stroma, which facilitates chemoresistance by creating physical and biological barriers to therapeutic agents. Thus, stroma-depleting agents may enhance the delivery and efficacy of chemotherapy drugs. However, stroma-targeting therapy for pancreatic cancer is a double-edged sword, as the stroma can also inhibit tumor metastasis and malignancy. In-depth understanding of the critical role of the stroma in cancer metastasis may improve therapeutic approaches by allowing them to harness specific features of the stroma to treat pancreatic cancer.
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research