Table of Contents
(Source: Archives of Medical Research)
Source: Archives of Medical Research - September 30, 2016 Category: Research Source Type: research

Instructions for Authors
(Source: Archives of Medical Research)
Source: Archives of Medical Research - September 30, 2016 Category: Research Source Type: research

COPB2 Is Upregulated in Prostate Cancer and Regulates PC-3 Cell Proliferation, Cell Cycle, and Apoptosis
Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers. Coatomer complex I (COPI)-coated vesicles are involved in the transport between endoplasmic reticulum (ER) and Golgi complex. Several studies indicated that some subunits of COPI were correlated with the cell proliferation of malignant tumors. The present study focused on the function of coatomer protein complex subunit β 2 (COPB2), one of seven proteins in COPI, in prostate cancer (PCa). (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Yuanyuan Mi, Menglei Yu, Lifeng Zhang, Chuanyu Sun, Bingbing Wei, Weihong Ding, Yingfeng Zhu, Jianmin Tang, Guowei Xia, Lijie Zhu Tags: Original Article Source Type: research

Ischemic Postconditioning Before Percutaneous Coronary Intervention for Acute ST-Segment Elevation Myocardial Infarction Reduces Contrast-induced Nephropathy and Improves Long-term Prognosis
Contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is one of the major adverse outcomes affecting the prognosis of patients with acute ST-segment elevation myocardial infarction (STEMI). Ischemic postconditioning prior to PCI (pre-PCI) in patients with STEMI is hypothesized to be protective against CIN after PCI. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Yun-yun Wang, Tong Li, Ying-wu Liu, Yu Wang, Xiao-min Hu, Wen-qing Gao, Peng Wu, Xin Li, Wen-jin Peng, Wei Gao, Guang-dong Yu, Bo-jiang Liu Tags: Original Article Source Type: research

Intracellular Progesterone Receptor Mediates the Increase in Glioblastoma Growth Induced by Progesterone in the Rat Brain
Progesterone (P) is a steroid hormone involved in the development of several types of cancer including astrocytomas, the most common and malignant brain tumors. We undertook this study to investigate the effects of P on the growth and infiltration of a tumor caused by the xenotransplant of U87  cells derived from a human astrocytoma grade IV (glioblastoma) in the cerebral cortex of male rats and the participation of intracellular progesterone receptor (PR) on these effects. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Liliana Germ án-Castelán, Joaquín Manjarrez-Marmolejo, Aliesha González-Arenas, Ignacio Camacho-Arroyo Tags: Original Article Source Type: research

Evaluation of Circulating Tumor Cells in Predicting Therapeutic Response in Small Cell Lung Cancer Patients
This study examined the correlation of CTCs with the therapeutic response in small cell lung cancer (SCLC). (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Xu Wang, Kewei Ma, Yizhuo Wang, Hua He, Ji-fan Hu, Wei Li Tags: Original Article Source Type: research

Aberrant CpG Island Shore Region Methylation of CAV1 Is Associated with Tumor Progression and Poor Prognosis in Gastric Cardia Adenocarcinoma
Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis. However, the epigenetic changes of CAV1 in gastric cardia adenocarcinoma (GCA) have not been investigated so far. The purpose of this study was to clarify the contribution of critical CpG sites in CAV1 to progression/prognosis of GCA and to further elucidate the effect of critical CpG sites on the ectopic expression of β-catenin in GCA. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Yan-li Guo, Tie-nian Zhu, Wei Guo, Zhi-ming Dong, Zhen Zhou, Yu-jie Cui, Rui-jing Zhao Tags: Original Article Source Type: research

Vitamin B12 Deficiency Across Three Generations Adversely Influences Long-chain Polyunsaturated Fatty Acid Status and Cardiometabolic Markers in Rats
Vitamin B12 and omega-3 fatty acid deficiency is prevalent in the vegetarian population and is associated with adverse pregnancy outcomes and cardiometabolic risk. The present study investigates the long-term effects of vitamin B12 deficiency/supplementation in the presence of omega-3 fatty acids on cardiometabolic profile and long-chain polyunsaturated fatty acid levels (LCPUFA) in the F3 generation offspring. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi Tags: Original Article Source Type: research

Long Noncoding RNA Highly Up-regulated in Liver Cancer Predicts Unfavorable Outcome and Regulates Metastasis by MMPs in Triple-negative Breast Cancer
Long noncoding RNA (lncRNA) highly up-regulated in liver cancer (HULC) is the first identified lncRNA highly expressed in hepatocellular carcinoma and acts as an oncogenic lncRNA. However, the significance of HULC in triple-negative breast cancer (TNBC) is still unclear. Our purpose is to explore the clinical significance and biological function of HULC in TNBC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Feng Shi, Fang Xiao, Ping Ding, Hong Qin, Ruixue Huang Tags: Original Article Source Type: research

High Thyroid-stimulating Hormone Levels Increase Proinflammatory and Cardiovascular Markers in Patients with Extreme Obesity
Obesity is an important health problem worldwide and many studies have suggested a relationship between obesity and thyroid function, with controversial results. Interestingly, high TSH levels have been involved with the presence of inflammatory state and risk for developing cardiovascular diseases in hypothyroid and obese patients. The aim in this work was to determine the prevalence of hypothyroidism in patients with extreme obesity and to determine whether their TSH levels were related to increased serum levels of inflammatory and cardiovascular markers. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Jaime H éctor Gómez-Zamudio, Victoria Mendoza-Zubieta, Aldo Ferreira-Hermosillo, Marío Antonio Molina-Ayala, Adán Valladares-Sálgado, Fernando Suárez-Sánchez, Jose de Jesús Peralta-Romero, Miguel Cruz Tags: Original Article Source Type: research

Irisin and Myostatin Levels in Patients with Graves' Disease
Skeletal muscle system, which is one of the primary targets for thyroid hormones, has an important role in energy metabolism. Some myokines such as irisin and myostatin have considerable effects on energy metabolism in addition to the musculoskeletal system. Our aim was to investigate circulating irisin and myostatin levels in patients with Graves' Disease (GD). (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Mehmet Muhittin Yalcin, Mujde Akturk, Yusuf Tohma, Ethem Turgay Cerit, Alev Eroglu Altinova, Emre Arslan, Ilhan Yetkin, Fusun Balos Toruner Tags: Original Article Source Type: research

Response: Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter
We appreciate the Letter commenting on our article. The analysis of the excess deaths and years of life lost associated with each wave of the A/H1N1 influenza pandemic 2009 –2010 in Mexico showed that the impact of each pandemic wave differed greatly with 14 and 75% of the total excess all-cause deaths occurring in (April–May 2009) and (August–December 2009) respectively (1). (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Constantino L ópez-Macías, Eduardo Ferat-Osorio, Lourdes Arriaga-Pizano Tags: Letter to the Editor Source Type: research

Influenza and Immune Profile
Arriaga-Pizano et  al. (1) published an interesting article about the immune differences of the two waves of the influenza virus in the Mexican population in 2009. A significant elevation of IL-6 (>10 fold above controls), IL-4 and IL 10 was observed in the second wave with respect to the first. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Jose Luis Sandoval-Gutierrez Tags: Letter to the Editor Source Type: research

Effects of Castanospermine on Inflammatory Response in a Rat Model of  Experimental Severe Acute Pancreatitis
This study investigated the effects of CAST on sodium taurocholate (STC)-induced severe acute pancreatitis (SAP) in rats and the pertinent mechanism. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Authors: Yu-pu Hong, Chen Chen, Wen-yi Guo, Liang Zhao, Fang-chao Mei, Ming-wei Xiang, Wei-xing Wang Tags: Original Article Source Type: research

Editorial Board
(Source: Archives of Medical Research)
Source: Archives of Medical Research - July 31, 2016 Category: Research Source Type: research