Aberrant CpG Island Shore Region Methylation of CAV1 Is Associated with Tumor Progression and Poor Prognosis in Gastric Cardia Adenocarcinoma
Caveolin-1 (CAV1) is a multifunctional scaffolding protein and plays an important role in tumorigenesis. However, the epigenetic changes of CAV1 in gastric cardia adenocarcinoma (GCA) have not been investigated so far. The purpose of this study was to clarify the contribution of critical CpG sites in CAV1 to progression/prognosis of GCA and to further elucidate the effect of critical CpG sites on the ectopic expression of β-catenin in GCA.
Source: Archives of Medical Research - Category: Research Authors: Yan-li Guo, Tie-nian Zhu, Wei Guo, Zhi-ming Dong, Zhen Zhou, Yu-jie Cui, Rui-jing Zhao Tags: Original Article Source Type: research