Reviewers 2016
Archives of Medical Research extended their appreciation to the following reviewers for their assistance during 2016: (Source: Archives of Medical Research)
Source: Archives of Medical Research - January 1, 2017 Category: Research Source Type: research
Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents
Malnutrition has been identified as a prognostic factor in children and adolescents with leukemia. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Ronald D. Barr, David Gomez-Almaguer, Jose Carlos Jaime-Perez, Guillermo J. Ruiz-Arg üelles Tags: Review Article Source Type: research
Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group
The understanding of leukemogenesis in early-age acute leukemia (EAL) has improved remarkably. Initiating somatic mutations detected in dried neonatal blood spots (DNBS) and in cord blood samples of affected children with leukemia have been proven to be acquired prenatally. However, to date, few epidemiological studies have been carried out exploring EAL that include infants and children 13 –24 months of age at the diagnosis. Maternal exposure to transplacental DNA-damaging substances during pregnancy has been suggested to be a risk factor for EAL. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Maria S. Pombo-de-Oliveira, Francianne Gomes Andrade, Brazilian Collaborative Study Group of Infant Acute Leukaemia Tags: Review Article Source Type: research
Molecular Characterization of Pediatric Acute Myeloid Leukemia: Results of a Multicentric Study in Brazil
The biological characterization of childhood acute myeloid leukemia (c-AML) is an important outcome predictor. In Brazil, very little is known about the frequency of AML subgroups, although c-AML accounts for about 18% of leukemias. We carried out this study to investigate the contribution of type I and II gene mutations in the probability of overall survival (pOS) of c-AML in Brazil. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Francianne Gomes Andrade, Elda Pereira Noronha, Gisele Dallapicola Brisson, Filipe dos Santos Vicente Bueno, Ingrid Sardou Cezar, Eug ênia Terra-Granado, Luiz Claudio Santos Thuler, Maria S. Pombo-de-Oliveira, Brazilian Study Group of Childhood Acute Mye Tags: Original Article Source Type: research
Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia
This study examined whether Ras mutation could define a unique etiologic group of childhood ALL associated with tobacco smoke, a well-established mutagen and carcinogen. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Maneet Kaur, Adam J. de Smith, Steve Selvin, Luoping Zhang, Marc Cunningham, Michelle W. Kang, Helen M. Hansen, Robert M. Cooper, Roberta McKean-Cowdin, Joseph L. Wiemels, Catherine Metayer Tags: Original Article Source Type: research
Environmental Exposure and Risk of Childhood Leukemia: An Overview
Childhood leukemia is the most common cancer diagnosed in children worldwide. However, only a few causes have been established so far, mainly some genetic syndromes and high doses of ionizing radiation. Major efforts have been undertaken to study the relationship between environmental factors and the risk of childhood leukemia, inspired by geographical variation in incidence rates. Some evidence has emerged for parental occupational exposures to pesticides, whereas there is less evidence for an association with postnatal pesticide exposure. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Joachim Sch üz, Friederike Erdmann Tags: Review Article Source Type: research
Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients
It has been demonstrated that heterozygote and homozygote thiopurine S-methyltransferase (TPMT) mutant allele carriers are at high risk to develop severe and potentially fatal hematopoietic toxicity after treatment with standard doses of 6-mercaptopurine (6-MP) and methotrexate (MX). Those drugs are the backbone of acute lymphoblastic leukemia (ALL) and several autoimmune disease treatments. We undertook this study to determine the frequency of the TPMT deficient alleles in children with ALL and non-ALL subjects from Mexico City and Yucatan, Mexico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Silvia Jim énez-Morales, Mireya Ramírez-Florencio, Juan Manuel Mejía-Aranguré, Juan Carlos Núñez-Enríquez, Carolina Bekker-Mendez, José Luis Torres-Escalante, Janet Flores-Lujano, Elva Jiménez-Hernández, María del Carmen Rodríguez-Zepeda, Yeld Tags: Original Article Source Type: research
Copy Number Alterations Associated with Acute Lymphoblastic Leukemia in Mexican Children. A report from The Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia
B-cell precursor acute lymphocytic leukemia (B-ALL) represents a worldwide public health issue. Particularly, Mexico is one of the countries with the highest incidence of ALL in children. Between the multiple factors involved in ALL etiology, genetic alterations are clearly one of the most relevant features. In this work, a group of 24 B-ALL patients, all negative for the four most frequent gene fusions (ETV6-RUNX1, BCR-ABL1, TCF3-PBX1 and MLL-AF4), were included in a high-resolution microarray analysis in order to evaluate genomic copy-number alterations (CNAs). (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Beatriz Rosales-Rodr íguez, Fernando Fernández-Ramírez, Juan Carlos Núñez-Enríquez, Ana Claudia Velázquez-Wong, Aurora Medina-Sansón, Elva Jiménez-Hernández, Janet Flores-Lujano, José Gabriel Peñaloza-González, Rosa Martha Espinosa-Elizondo, Tags: Preliminary Report Source Type: research
ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A MIGICCL Study
Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reproducible ALL associated-risk alleles in different populations. The aim of the present study was to examine the contribution of ARID5B, CEBPE, and PIP4K2 risk alleles for the development of ALL in children from Mexico City and Yucatan, Mexico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Vilma Carolina Bekker-M éndez, Juan Carlos Núñez-Enríquez, José Luis Torres Escalante, Enrique Alvarez-Olmos, Pablo Miguel González-Montalvoc, Elva Jiménez-Hernández, Aurora Medina Sansón, Yelda A. Leal, María Teresa Ramos-Cervantes, Francisco X Tags: Original Article Source Type: research
Analysis of Normal Hematopoietic Stem and Progenitor Cell Contents in Childhood Acute Leukemia Bone Marrow
Childhood acute leukemias (AL) are characterized by the excessive production of malignant precursor cells at the expense of effective blood cell development. The dominance of leukemic cells over normal progenitors may result in either direct suppression of functional hematopoiesis or remodeling of microenvironmental niches, contributing to BM failure and AL-associated mortality. We undertook this study to investigate the contents and functional activity of hematopoietic stem/progenitor cells (HSPC) and their relationship to immune cell production and risk status in AL pediatric patients. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Juan Carlos Balandr án, Eduardo Vadillo, David Dozal, Alfonso Reyes-López, Antonio Sandoval-Cabrera, Merle Denisse Laffont-Ortiz, Jessica L. Prieto-Chávez, Armando Vilchis-Ordoñez, Henry Quintela-Nuñez del Prado, Héctor Mayani, Juan Carlos Núñez-E Tags: Original Article Source Type: research
Gene Expression Profiling of Acute Lymphoblastic Leukemia in Children with Very Early Relapse
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide. Mexican patients have high mortality rates, low frequency of good prognosis biomarkers (i.e., ETV6-RUNX1) and a high proportion is classified at the time of diagnosis with a high risk to relapse according to clinical features. In addition, very early relapses are more frequently observed than in other populations. The aim of the study was to identify new potential biomarkers associated with very early relapse in Mexican ALL children through transcriptome analysis. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Juan Carlos N úñez-Enríquez, Diego Alberto Bárcenas-López, Alfredo Hidalgo-Miranda, Elva Jiménez-Hernández, Vilma Carolina Bekker-Méndez, Janet Flores-Lujano, Karina Anastacia Solis-Labastida, Gabriela Bibiana Martínez-Morales, Fausto Sánchez-Mu Tags: Original Article Source Type: research
Parental Exposure to Workplace Carcinogens and the Risk of Development of Acute Leukemia in Infants. Case-Control Study
Occupational exposure of parents to carcinogens is of great interest in the etiology of leukemias. Evidence of the impact of such exposure on infants or small children is scarce. Here we estimated whether occupational exposure of parents to carcinogens could be a risk factor for leukemias in their children. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Mar ía Luisa Pérez-Saldivar, Arturo Fajardo-Gutiérrez, José Alfredo Sierra-Ramírez, Nancy Núñez-Villegas, Héctor Pérez-Lorenzana, Elisa María Dorantes-Acosta, Pedro Francisco Román-Zepeda, María del Carmen Rodríguez-Zepeda, Juana Esther Gonz Tags: Original Article Source Type: research
Results of Treating Childhood Acute Lymphoblastic Leukemia in a Low-middle Income Country: 10 Year Experience in Northeast Mexico
In high-income countries, treatment protocols for acute lymphoblastic leukemia (ALL) in children lead to a 5-year overall survival (OS) approaching 90%. There is scarce information on protocols and results of therapy from low-middle income countries (LMIC). We documented the results of treating children with ALL with two protocols in consecutive 5-year periods at a reference center in northeast Mexico. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Jos é C. Jaime-Pérez, Olga Nidia López-Razo, Gisela García-Arellano, Mónica Andrea Pinzón-Uresti, Raúl A. Jiménez-Castillo, Oscar González-Llano, David Gómez-Almaguer Tags: Original Article Source Type: research
Acute Leukemias in Children
Acute leukemia is the most common type of childhood cancer. Despite having a common term to denominate these diseases, it encloses several subtypes that, depending on their morphological, biological and molecular features, clinical presentation, response to chemotherapy and survival are determined. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Juan Manuel Mej Ía-Aranguré, Maria S. Pombo-de-Oliveira, Charles G. Mullighan Tags: Preface Source Type: research
Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy
The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Corrado Magnani, Alessandra Ranucci, Chiara Badaloni, Giulia Cesaroni, Daniela Ferrante, Lucia Miligi, Stefano Mattioli, Roberto Rondelli, Luigi Bisanti, Paola Zambon, Santina Cannizzaro, Paola Michelozzi, Pierluigi Cocco, Egidio Celentano, Giorgio Assenn Tags: Original Article Source Type: research
