Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group

The understanding of leukemogenesis in early-age acute leukemia (EAL) has improved remarkably. Initiating somatic mutations detected in dried neonatal blood spots (DNBS) and in cord blood samples of affected children with leukemia have been proven to be acquired prenatally. However, to date, few epidemiological studies have been carried out exploring EAL that include infants and children 13 –24 months of age at the diagnosis. Maternal exposure to transplacental DNA-damaging substances during pregnancy has been suggested to be a risk factor for EAL.
Source: Archives of Medical Research - Category: Research Authors: Tags: Review Article Source Type: research