ARID5B, CEBPE and PIP4K2A Germline Genetic Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia in Mexican Patients: A  MIGICCL Study

Childhood acute lymphoblastic leukemia (ALL) is the leading cause of childhood cancer-related deaths worldwide. Multiples studies have shown that ALL seems to be originated by an interaction between environmental and genetic susceptibility factors. The ARID5B polymorphisms are among the most reproducible ALL associated-risk alleles in different populations. The aim of the present study was to examine the contribution of ARID5B, CEBPE, and PIP4K2 risk alleles for the development of ALL in children from Mexico City and Yucatan, Mexico.

Source: Archives of Medical Research - November 1, 2016 Category: Research Authors: Vilma Carolina Bekker-M éndez, Juan Carlos Núñez-Enríquez, José Luis Torres Escalante, Enrique Alvarez-Olmos, Pablo Miguel González-Montalvoc, Elva Jiménez-Hernández, Aurora Medina Sansón, Yelda A. Leal, María Teresa Ramos-Cervantes, Francisco X Tags: Original Article Source Type: research