Selective Screening of Fatty Acids Oxidation Defects and Organic Acidemias by Liquid Chromatography/tandem Mass Spectrometry Acylcarnitine Analysis in Brazilian Patients
Inborn errors of metabolism (IEM) are diseases which can lead to accumulation of toxic metabolites in the organism. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Carmen Regla Vargas, Graziela Schmitt Ribas, Janine Machado da Silva, Angela Sitta, Marion Deon, Daniella de Moura Coelho, Moacir Wajner Tags: Original Article Source Type: research
Data Mining and Endocrine Diseases: A New Way to Classify?
Data mining consists of using large database analysis to detect patterns, relationships and models in order to describe (or even predict) the appearance of a future event; to accomplish this, it uses classification methods, rules of association, regression patterns, link and cluster analyses. Recently this approach has been used to propose a new diabetes mellitus classification, using information analysis techniques through which the selection bias minimally influences categorization, this new focus that includes data mining previously implemented to predict, identify biomarkers, complications, therapies, health policies, ...
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Juan Salazar, Cristobal Espinoza, Andres Mindiola, Valmore Bermudez Tags: Opinion Source Type: research
Impact of miR-302b on Calcium-phosphorus Metabolism and Vascular Calcification of Rats with Chronic Renal Failure by Regulating BMP-2/Runx2/Osterix Signaling Pathway
To investigate how miR-302b affect the calcium-phosphorus metabolism and vascular calcification (VC) of rats with chronic renal failure (CRF) via the regulation of bone morphogentic proteins 2/Runt-related transcription factor 3/Osterix (BMP-2/Runx2/Osterix) signaling pathway. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Wen-li Sun, Nan Wang, Yan Xu Tags: Original Article Source Type: research
Cardiometabolic Risk Indicators for Kidney Disease in Mexican Patients with Type 2 Diabetes
The objective of this study was to identify the primary risk factors associated with kidney disease in Mexican patients with type 2 diabetes. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Lubia Vel ázquez-López, Rubí Hernández-Sánchez, Ivonne Roy García, Abril Violeta Muñoz-Torres, Patricia Medina-Bravo, Jorge Escobedo-de la Peña Tags: Original Article Source Type: research
Endothelial Colony-forming Cells Attenuate Ventilator-induced Lung Injury in Rats with Acute Respiratory Distress Syndrome
Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Ying-nan Ju, Jing Gong, Xue-ting Wang, Jing-li Zhu, Wei Gao Tags: Original Article Source Type: research
Role of Response-to-Diuretic in Predicting Prognosis in Discharged Heart Failure Patients After an Acute Decompensation
The objectives of this clinical research, will aim are to: a) include diuresis in the formula for diuretic response (R-to-D); b) add to R-to-D the value of a pre-discharged determination of galectin-3 and BNP in predicting mid-term clinical outcome. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 14, 2018 Category: Research Authors: Mauro Feola, Marzia Testa, Cinzia Ferreri, Marco Cardone, Mario Sola, Sara Ariotti, Gian Luca Rosso Tags: Original Article Source Type: research
Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats
Insulin sensitizers like metformin and pioglitazone are clinically used since last decades for the treatment of PCOS, but their efficacy and possible role in PCOS patients remains questionable. Also, the mechanism by which these insulin sensitizers show effect is not clear. (Source: Archives of Medical Research)
Source: Archives of Medical Research - August 10, 2018 Category: Research Authors: Roshni Patel, Gaurang Shah Tags: Original Article Source Type: research
Improvement in the Diagnosis of Tuberculosis Combining Mycobacterium Tuberculosis Immunodominant Peptides and Serum Host Biomarkers
Pulmonary tuberculosis (PTB) is a public health problem with 10.4 million new cases reported in 2017 (1). According to the World Health Organization (WHO), accurate diagnostic tests based in serum biomarkers to detect new cases of tuberculosis are necessary. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 20, 2018 Category: Research Authors: Juan E. L ópez-Ramos, Noe Macías-Segura, Betzaida Cuevas-Cordoba, Zaida Araujo-Garcia, Yadira Bastián, Julio E. Castañeda-Delgado, Edgar E. Lara-Ramirez, Benjamin Gándara-Jasso, Carmen J. Serrano, Eva Salinas, Jose A. Enciso-Moreno Tags: Original Article Source Type: research
Serum Amyloid A, Paraoxonase-1 Activity, and Apolipoprotein Concentrations as Biomarkers of Subclinical Atherosclerosis Risk in Adrenal Incidentaloma Patients
Adrenal incidentalomas (AIs), particularly subclinical hypercortisolism (SH), are related to an increased risk of atherosclerosis. The anti-oxidative enzyme paraoxonase-1 (PON1) and the acute phase reactant serum amyloid A (SAA) are transported by highdensity lipoprotein and reciprocally regulated in acute inflammatory response. Our aim was to investigate serum SAA, PON1, and apolipoprotein levels as indicators of subclinical atherosclerosis in patients with nonfunctioning AI (NFAI) and SH. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 18, 2018 Category: Research Authors: Narin Nasiroglu Imga, Canan Topcuoglu, Dilek Berker, Turan Turhan Tags: Original Article Source Type: research
Human CATSPER1 Promoter Is Regulated by CREB1 and CREM τ Transcriptional Factors In Vitro
The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca2+ ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0 –2, in which CRE0 is located near the transcription start site. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Norma Oviedo, Lizdy Ortiz-Borrayo, Javier Hern ández-Sánchez, Salma Elizabeth Jiménez-Badillo, Tesoro Cruz Emiliano, Esperanza Moreno-Navor, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Méndez Tags: Original Article Source Type: research
Effect of Endoplasmic Reticulum Stress and Autophagy in the Regulation of Post-infarct Cardiac Repair
Acute myocardial infarction (AMI) is reported to be accompanied by endoplasmic reticulum (ER) stress and autophagy induction. Nevertheless, the roles of ER stress and autophagy in post-infarct reparative fibrosis remain to be elucidated. (Source: Archives of Medical Research)
Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Rongjie Lin, Zizhuo Su, Xiaohui Tan, Yinqing Su, Yuyang Chen, Xiaorong Shu, Shumin Liang, Jingfeng Wang, Shuanglun Xie Tags: Preliminary Report Source Type: research
Mannose Binding Lectin and Pentraxin 3 in Patients with Diabetic Retinopathy
Mannose binding lectin (MBL) is a protein of the complement system and pentraxin-3 (PTX3) is an acute phase protein both with an important role in inflammatory diseases, such as diabetic retinopathy (DR). (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 28, 2018 Category: Research Authors: Kenzo Hokazono, Fernando Sakata Beliz ário, Vanessa Portugal, Iara Messias-Reason, Renato Nisihara Tags: Preliminary Report Source Type: research
Health Systems in Latin America: The Search for Universal Health Coverage
This paper discusses the health challenges faced by countries in Latin America. These challenges have two dimensions: those related to the health needs of populations and those related to the way in which health systems are responding to these needs. The main conclusion is that in order to improve health conditions and move towards universal health coverage, Latin American countries need to design a new generation of policy innovations based on the separation of the three main functions of health systems: financing, delivery and stewardship. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 27, 2018 Category: Research Authors: Julio Frenk, Octavio G ómez-Dantés Source Type: research
Maternal Obesity as a Risk Factor for the Development of Total Anomalous Pulmonary Venous Connection in Their Offspring
The incidence of total anomalous pulmonary venous connection (TAPVC) in the Caucasian population is 2.5/100,000 live births (LB), and the incidence in the Hispanic population is 19.8/100,000 LB. Without knowing the exact etiology for the development of congenital heart disease, our objective was to determine the maternal factors associated with the development of TAPVC. (Source: Archives of Medical Research)
Source: Archives of Medical Research - June 12, 2018 Category: Research Authors: Evelyn G. Alvarado-Terrones, Maryangel Perea-Cabrera, Miguel Kl ünder-Klünder, Begoña Segura-Stanford, Julio R. Erdmenger-Orellana, Arturo Lopez-Yañez Blanco, Elizabeth Hernández-Carbajal, Javier T. Granados Riverón, Leonardo J. Mejía-Marín, Norma Source Type: research
Pathway to Tau Modifications and the Origins of Alzheimer's Disease
Several studies have pointed to the mechanisms on how the microtubule-associated protein tau, once modified, triggers a cascade of molecular events that are the main culprit of Alzheimer's disease and tauopathies. These discoveries have been considered as one of the main breakthroughs in science during this first part of this century. The critical reaction is the anomalous phosphorylation of tau by the complex kinase systems CDK5/p35 and GSK3 β (1). There is cumulative evidence that once tau protein is hyperphosphorylated, it turns into a neurotoxic agent that promotes neuronal degeneration and also neuronal death. (Sourc...
Source: Archives of Medical Research - May 31, 2018 Category: Research Authors: Ricardo B. Maccioni, Jos é Pablo Tapia, Leonardo Guzman-Martinez Source Type: research
