Human CATSPER1 Promoter Is Regulated by CREB1 and CREM τ Transcriptional Factors In Vitro

The CATSPER1 gene encodes a CATSPER channel protein that selectively permeates Ca2+ ions, and CATSPER expression in sperm is essential for flagellum hyperactivation and, thus, male fertility. Little is known regarding the transcriptional regulation of CATSPER1, but previous studies have performed in silico analyses of transcription factor binding sites, including three CRE sites designated 0 –2, in which CRE0 is located near the transcription start site.

Source: Archives of Medical Research - July 15, 2018 Category: Research Authors: Norma Oviedo, Lizdy Ortiz-Borrayo, Javier Hern ández-Sánchez, Salma Elizabeth Jiménez-Badillo, Tesoro Cruz Emiliano, Esperanza Moreno-Navor, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Méndez Tags: Original Article Source Type: research