American Journal of Reproductive Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Genome ‐wide identification of microRNAs in decidual natural killer cells from patients with unexplained recurrent spontaneous abortion
ConclusionOur results suggest that a close relationship exists between the aberrant miRNAs and URSA. Furthermore, these findings support the notion that altered expression of miRNAs may contribute to the clinical diagnosis of URSA and the potential to develop novel strategies for therapeutic targets against URSA. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Dandan Li, Jian Li, Bin Jia, Yue Wang, Juxin Zhang, Guangzhi Liu Tags: SHORT COMMUNICATION Source Type: research

Fetal sexual dimorphism in systemic soluble fms ‐like tyrosine kinase 1 among normotensive and preeclamptic women
ConclusionOur results are similar with other studies suggesting that women with female fetuses have increased sFLT levels. However, significant difference was only among women with preeclampsia. This study was exploratory and longitudinal investigations across pregnancy are required to understand the relationship between fetal sex and systemic maternal angiogenic biomarkers. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Brandie D. Taylor, Catherine L. Haggerty, Roberta B. Ness, David M. Hougaard, Kristin Skogstrand, James M. Roberts, J ørn Olsen Tags: SHORT COMMUNICATION Source Type: research

Does per ‐act HIV‐1 transmission risk through anal sex vary by gender? An updated systematic review and meta‐analysis
Forest plot of studies estimating per ‐act HIV‐1 transmission probability through anal intercourse. Quantifying HIV ‐1 transmission risk per‐act of anal intercourse (AI) is important for HIV‐1 prevention. We updated previous reviews by searching Medline and Embase to 02/2018. We derived pooled estimates of receptive AI (URAI) and insertive AI (UIAI) risk unprotected by condoms using random‐effects models. Subgroup analyses were conducted by gender, study design, and whether antiretroviral treatment (ART) had been introduced by the time of the study. Two new relevant studies were identified, one of which met inc...
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Rebecca F. Baggaley, Branwen N. Owen, Romain Silhol, Jocelyn Elmes, Peter Anton, Ian McGowan, Ariane Straten, Barbara Shacklett, Que Dang, Edith M. Swann, Diane L. Bolton, Marie ‐Claude Boily Tags: REVIEW ARTICLE Source Type: research

Recurrent pregnancy loss and vitamin D: A review of the literature
Recurrent pregnancy loss (RPL) affects approximately 1% ‐2% of reproductive women. Auto‐ and cellular immune responses seem to be associated with RPL. Vitamin D (VD) has been shown to play a role in the modulation of the immune system. Effects of VD deficiency (VDD) in pregnancy have been associated with preeclampsia, gestational diabetes, fetal grow th restriction, preterm labor, and sporadic spontaneous abortion (SA). We systematically reviewed articles that studied women with 2 or more SA and its association with VD. Eleven studies were included. Studies reported a high prevalence of VD insufficiency (VDI) or VDD in...
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Daniela Reis Gon çalves, António Braga, Jorge Braga, António Marinho Tags: REVIEW ARTICLE Source Type: research

The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review
Initial studies on the chemokine stromal derived factor 1 (now referred to as CXCL12) were proposed to be enhanced in several diseases including those which affect the female reproductive tract. These include endometriosis, Asherman's syndrome, endometrial cancers, and ovarian cancers. Additionally, recent studies from our laboratory suggest that CXCL12 signaling is involved in leiomyomas (fibroids). These diseases present an inflammatory/hypoxic environment which further promotes pathology. At first, studies focused on signaling by CXCL12 via its well ‐known receptor, CXCR4. However, the discovery of CXCR7 as another re...
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Graciela Krikun Tags: REVIEW ARTICLE Source Type: research

Investigating the effect of an abnormal cervico ‐vaginal and endometrial microbiome on assisted reproductive technologies: A systematic review
The female reproductive tract has an active microbiome, and it is suggested that these microbes could influence the outcome of assisted reproductive technologies (ART). This systematic review aimed to assess the vaginal/uterine microbiome, specifically with regard to improving the outcome of ART. English peer ‐reviewed journals were searched for studies investigating the vaginal/uterine micriobiome and female reproductive tract, using PRISMA guidelines. Twenty‐six studies were included, 19 studying the vaginal and seven investigating the uterine microbiome. Studies using culture‐based technologies found an abnormal v...
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Timothy Bracewell ‐Milnes, Srdjan Saso, Dimitrios Nikolaou, Julian Norman‐Taylor, Mark Johnson, Meen‐Yau Thum Tags: REVIEW ARTICLE Source Type: research

Cover
The cover image is based on the Original ArticleInflammasome activation during spontaneous preterm labor with intra ‐amniotic infection or sterile intra‐amniotic inflammation, by Nardhy Gomez ‐Lopez et al., DOI10.1111/aji.13049. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Nardhy Gomez ‐Lopez, Roberto Romero, Bogdan Panaitescu, Yaozhu Leng, Yi Xu, Adi L. Tarca, Jonathan Faro, Percy Pacora, Sonia S. Hassan, Chaur‐Dong Hsu Tags: COVER Source Type: research

Issue Information
American Journal of Reproductive Immunology, Volume 80, Issue 5, November 2018. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Tags: ISSUE INFORMATION Source Type: research

Humoral immunity in late ‐onset Pre‐eclampsia and linkage with angiogenic and inflammatory markers
ConclusionWe describe for the first time that PE is independently associated with activation of the humoral immune system independent of deranged kidney function and angiogenic markers. The role of B2 ‐M as a potential predictive marker of PE remains to be determined. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Nadia Sarween, Mark T. Drayson, James Hodson, Ellen M. Knox, Timothy Plant, Clara J. Day, Graham W. Lipkin Tags: ORIGINAL ARTICLE Source Type: research

Amniotic fluid proteomic signatures of cervical insufficiency and their association with length of latency
ConclusionIn this pilot study, significant differences in the amniotic fluid proteomic profiles in cases of cervical insufficiency compared to genetic amniocentesis were observed. Proteomic signatures were predictive of achieving latency> 1  week after diagnosis of cervical insufficiency. These preliminary findings suggest that proteomic analysis may be of value in predicting outcome following cervical insufficiency and warrants further validation in larger studies. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Rachelle N. M. Govia, Kenzie D. Birse, Shadi Sepehri, Ehsan Khafipour, Savas M. Menticoglou, Adam D. Burgener, Vanessa Poliquin Tags: ORIGINAL ARTICLE Source Type: research

Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll ‐Like receptor 4
ConclusionThe findings from this study indicate a novel mechanism by which hyperglycemia may impact trophoblast function, early placentation, and ultimately, pregnancy outcome. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Kathleen R. Heim, Melissa J. Mulla, Julie A. Potter, Christina S. Han, Seth Guller, Vikki M. Abrahams Tags: ORIGINAL ARTICLE Source Type: research

Inflammasome activation during spontaneous preterm labor with intra ‐amniotic infection or sterile intra‐amniotic inflammation
ConclusionInflammasome activation occurs in the settings of intra ‐amniotic infection and sterile intra‐amniotic inflammation during spontaneous preterm labor. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Nardhy Gomez ‐Lopez, Roberto Romero, Bogdan Panaitescu, Yaozhu Leng, Yi Xu, Adi L. Tarca, Jonathan Faro, Percy Pacora, Sonia S. Hassan, Chaur‐Dong Hsu Tags: ORIGINAL ARTICLE Source Type: research

Associations of maternal immune response with MeHg exposure at 28 weeks ’ gestation in the Seychelles Child Development Study
ConclusionMaternal MeHg was associated with markers of immune function at 28  weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Emeir M. McSorley, Alison J. Yeates, Maria S. Mulhern, Edwin Wijngaarden, Katherine Grzesik, Sally W. Thurston, Toni Spence, William Crowe, Philip W. Davidson, Grazyna Zareba, Gary J. Myers, Gene E. Watson, Conrad F. Shamlaye, J. J. Strain Tags: ORIGINAL ARTICLE Source Type: research

Progesterone and cyclic adenosine monophosphate down ‐regulate CD90 in the stromal cells of human decidua. In vitro evidence and in situ findings
ConclusionDSCs in early pregnancy show different levels of CD90 expression, suggesting different DSC differentiation and selective interactions with cells during decidual morphogenesis. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Кameliya Vinketova, Iliya Karagyozov, Vesselina Koleva, Michael Hristov, Milena Mourdjeva, Markus Sperandio, Tsvetelina Oreshkova Tags: ORIGINAL ARTICLE Source Type: research

Estradiol ‐regulated innate antiviral responses of human endometrial stromal fibroblasts
ConclusionStromal fibroblasts represent a level of innate immune protection against viral pathogens in the FRT beyond that seen with epithelial cells and immune cells. Our findings indicate that fibroblasts FRT are selectively responsive toE2, capable of initiating an antiviral response against viral pathogens and may play a role in preventing HIV infection of CD4+ T cells. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Mickey V. Patel, Zheng Shen, Richard M. Rossoll, Charles R. Wira Tags: ORIGINAL ARTICLE Source Type: research