Estradiol ‐regulated innate antiviral responses of human endometrial stromal fibroblasts

ConclusionStromal fibroblasts represent a level of innate immune protection against viral pathogens in the FRT beyond that seen with epithelial cells and immune cells. Our findings indicate that fibroblasts FRT are selectively responsive toE2, capable of initiating an antiviral response against viral pathogens and may play a role in preventing HIV infection of CD4+ T cells.

Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Mickey V. Patel, Zheng Shen, Richard M. Rossoll, Charles R. Wira Tags: ORIGINAL ARTICLE Source Type: research