Associations of maternal immune response with MeHg exposure at 28 weeks ’ gestation in the Seychelles Child Development Study

ConclusionMaternal MeHg was associated with markers of immune function at 28  weeks’ gestation. A significant interaction between MeHg and the n‐6:n‐3 ratio on the Th1:Th2 ratio suggests that the n‐3 PUFA may mitigate any immunosuppressive associations of MeHg. The n‐3 and n‐6 PUFA were associated with suppressive and stimulatory immune responses, respectively. Overall, the associations were of small magnitude, and further research is required to determine the clinical significance.

Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Emeir M. McSorley, Alison J. Yeates, Maria S. Mulhern, Edwin Wijngaarden, Katherine Grzesik, Sally W. Thurston, Toni Spence, William Crowe, Philip W. Davidson, Grazyna Zareba, Gary J. Myers, Gene E. Watson, Conrad F. Shamlaye, J. J. Strain Tags: ORIGINAL ARTICLE Source Type: research