Excess glucose induce trophoblast inflammation and limit cell migration through HMGB1 activation of Toll ‐Like receptor 4

ConclusionThe findings from this study indicate a novel mechanism by which hyperglycemia may impact trophoblast function, early placentation, and ultimately, pregnancy outcome.

Source: American Journal of Reproductive Immunology - October 25, 2018 Category: Allergy & Immunology Authors: Kathleen R. Heim, Melissa J. Mulla, Julie A. Potter, Christina S. Han, Seth Guller, Vikki M. Abrahams Tags: ORIGINAL ARTICLE Source Type: research