Posterior pharyngeal wall augmentation.
Authors: Perez CF, Brigger MT
Abstract
Posterior pharyngeal wall augmentation is a useful technique in selected patients with velopharyngeal insufficiency who have a small central velopharyngeal gap. Options for augmenting this region include using posterior pharyngeal wall flaps to create bulk and implanting various materials to fill in the central deficiency. Autologous and nonautologous implant materials are available and may be implanted through an incision or directly injected into the posterior pharyngeal wall. Previously described materials for implantation include cartilage, fat, fascia, silicone, ...
Source: Advances in Oto-Rhino-Laryngology - March 5, 2015 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Persistent velopharyngeal insufficiency.
Authors: Willging JP
Abstract
This chapter outlines the management of patients who have failed initial surgical correction of velopharyngeal insufficiency. Clinical judgment is required to determine the most appropriate revision option for each patient. © 2015 S. Karger AG, Basel.
PMID: 25733236 [PubMed - in process] (Source: Advances in Oto-Rhino-Laryngology)
Source: Advances in Oto-Rhino-Laryngology - March 5, 2015 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Obstructive sleep apnea.
Authors: Willging JP
Abstract
This chapter outlines the surgical management of children who experience symptoms of airway obstruction after undergoing pharyngeal flap surgery or sphincter pharyngoplasty for the correction of velopharyngeal insufficiency. It also describes the management of children with hyponasality following these corrective surgical interventions. © 2015 S. Karger AG, Basel.
PMID: 25733237 [PubMed - in process] (Source: Advances in Oto-Rhino-Laryngology)
Source: Advances in Oto-Rhino-Laryngology - March 5, 2015 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Abnormalities of glycogenes in tonsillar lymphocytes in IgA nephropathy.
This study investigated tonsillar B lymphocytes of IgAN using tonsils from patients with chronic tonsillitis and sleep apnea syndrome. Gene expression of β1,3-galactosyltransferase (β3GalT), Cosmc, UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyl-transferase 2, were significantly down regulated in tonsillar CD19-positive B lymphocytes from IgAN patients compared to control as determined by real-time RT-PCR. In contrast, the level of sialyltransferase was not significantly different among the three groups. Tonsillar B cell β3GalT gene expression significantly correlated with estimated GFR and negativel...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Microarray analysis of tonsils of IgA nephropathy patients.
Authors: Iwatani H, Iio K, Nagasawa Y, Yamamoto R, Horii A, Okuzaki D, Inohara H, Nojima H, Imai E, Rakugi H, Isaka Y
Abstract
IgA nephropathy (IgAN) is the most common primary glomerulonephritis. Its close relation with the tonsils is well known because tonsillitis sometimes causes aggravation of urinary findings or macrohematuria. However, the genes specific to the tonsils of IgAN patients are not clarified. To clarify the specific gene expression in the tonsils of IgAN patients, we performed tonsillectomy and corticosteroid IV therapy as a treatment of IgAN, analyzed the gene expression in the tonsils b...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Reactive arthritis induced by tonsillitis: a type of 'focal infection'.
DISCUSSION: Sterile inflammatory arthritis induced by tonsillitis was cured by resection of the microabscess in the tonsils. Therefore, ReA induced by tonsillitis is one form of 'focal infection'.
PMID: 21865696 [PubMed - indexed for MEDLINE] (Source: Advances in Oto-Rhino-Laryngology)
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Tonsil-related skin diseases and possible involvement of T cell co-stimulation in chronic focal infection.
Authors: Kobayashi S
Abstract
Some inflammatory skin diseases are known to be related to tonsil focal infection at their onset. Administration of antibiotics is adequate treatment in most acute or subacute cases. However, chronic focal infections in the tonsils could cause chronic skin diseases like pustulosis palmaris et plantaris (PPP), and it is our frequent experience that tonsillectomy leads to a dramatic and persistent improvement of PPP skin lesions. The expression of inducible co-stimulator (ICOS), a co-stimulatory receptor on activated T cells, was significantly higher in tonsil tissues from PPP p...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils.
Authors: Takahara M
Abstract
Palmoplantar pustulosis (PPP) is famous for causing typical tonsillar focal diseases. Clinical improvement of PPP rash after tonsillectomy was seen in 109 (94%) of 116 patients by subjective self-assessment, and 52 (88%) of 59 patients by objective Palmoplantar Pustulosis Area and Severity Index (PPPASI) scoring. Flow-cytometric analyses revealed that expression of activation markers (CD25 and HLA) class II increased on tonsillar T cells from PPP and IgAN patients. Moreover, expressions of skin-homing receptors (CLA and CCR6) increased on tonsillar T cells from PPP patients. In...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Triggering role of focal infection in the induction of extra-palmoplantar lesions and pustulotic arthro-osteitis associated with palmoplantar pustulosis.
Authors: Yamamoto T
Abstract
Palmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles of middle-aged women. Whether PPP is the acral type of pustular psoriasis or a distinct entity has long been discussed; however, the clinical features of PPP are really heterogeneous and different between Asians and Caucasians, which may depend on the race with backgrounds of different HLAs. PPP is closely related with psoriasis, but considered to be a distinct entity in Japan. Although the pathogenesis of PPP is still poorly understood,...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Role of biofilms in chronic inflammatory diseases of the upper airways.
The objective of our studies was to document the presence of bacterial biofilms in recurrent and chronic infectious diseases of the upper airways (UA) (adenoiditis, tonsillitis, chronic rhinosinusitis) and to assess the association between the presence of biofilm and the maintenance of a chronic inflammation.
METHODS: 16 surgical samples of tonsils and adenoids from patients with UA infections and 24 samples of ethmoid mucosa from patients who underwent endoscopic sinus surgery for chronic rhinosinusitis (CRS) were cultured using conventional methods and subjected to scanning electron microscopy (SEM) to detect evi...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Regulation of microbiota by antimicrobial peptides in the gut.
Authors: Masuda K, Nakamura K, Yoshioka S, Fukaya R, Sakai N, Ayabe T
Abstract
The antimicrobial peptide is one of major effectors of the innate immunity, and is common in the entire multicellular organisms. In mammals, one family of antibacterial peptide named defensins plays a central role in host defense, especially in the epithelial surface such as oral cavity, skin and the intestine. Recently, the importance of the antimicrobial peptides has been widely recognized. The epithelium of the gut is a largest surface that is exposed to various pathogens in the environment. It is the Paneth cells that produc...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Evidence of the local immune status in the human larynx.
Authors: Nakashima T, Tomita H, Chitose S
Abstract
We have studied the presence of local immunity in the larynx and its role and development of laryngeal glands in the human larynx. The local immune status in laryngeal secretion or related tissue specimens from the laryngeal ventricle was examined and the results were analyzed between individuals with or without head and neck cancer. Laryngeal secretions or mucosal tissue specimens were obtained during the microscopic laryngeal surgery or at the time of the surgery of the larynx. The laryngeal secretion contained immunological factors such as IgG, IgM, IgA...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Short review on sublingual immunotherapy for patients with allergic rhinitis: from bench to bedside.
Authors: Kawauchi H, Goda K, Tongu M, Yamada T, Aoi N, Morikura I, Fuchiwaki T
Abstract
Sublingual immunotherapy has been considered to be a painless and effective therapeutic treatment for allergic rhinitis, and is known as type 1 allergy of the nasal mucosa. So far, its mechanism of action has been elucidated employing peripheral blood serum and lymphocytes in an antigen-specific fashion. Because of the limitations in sampling human materials, there is still controversy among many reports between clinical efficacy and laboratory data. Therefore, its mechanism of action needs to be investigated further by...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Differential properties of mucous glycoproteins produced by allergic inflammation and lipopolysaccharide stimulation in rat nasal epithelium.
Authors: Shimizu T, Shimizu S
Abstract
To examine the differential properties of mucous glycoproteins, we produced hyperplastic and metaplastic changes in goblet cells of rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA-sensitized rats, and by intranasal lipopolysaccharides (LPS) instillation. The epithelial mucosubstance was quantitatively examined by AB-PAS and lectin histochemistry. The newly produced mucin after OVA challenge or LPS instillation contained a high amount of sulfomucin and a low amount of neutral glycoprotein: LPS-induced mucin contained more sulfomucin (70.1% of ...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
Nasal-associated lymphoid tissue immunity and vaccine development.
Authors: Kodama S, Suzuki M
Abstract
Nasal vaccination is an effective therapeutic regimen for preventing upper respiratory infectious diseases. In the development of nasal vaccine, an appropriate adjuvant is required. In the present study, we examined the efficacy of fms-like tyrosine kinase receptor-3 ligand (Flt3L) as a mucosal adjuvant. Mice were immunized intranasally with Flt3L and P6 protein of nontypeable Haemophilus influenzae (NTHi), and P6-specific immune responses were examined. In addition, NTHi challenges were performed and the level of NTHi was quantified in nasal washes. Nasal vaccination w...
Source: Advances in Oto-Rhino-Laryngology - December 2, 2014 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research
