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Encouraging clinical results for an antibody drug to prevent or treat HIV
A drug known as 10-1074, based on a human antibody against HIV, has dramatically reduced virus levels in patients and appeared to prevent infection among those at high risk, according to data from a new clinical trial. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - February 6, 2017 Category: Biomedical Science Authors: Wynne Perry Tags: Science News 10-1074 3BNC117 antibody therapy broadly neutralizing antibodies HIV Laboratory of Molecular Immunology Marina Caskey Michel Nussenzweig Till Schoofs Source Type: news

Atomic-scale view of bacterial proteins offers path to new tuberculosis drugs
In studying a cousin of the bacterium that causes tuberculosis, scientists have drawn a molecular map of the target for rifampicin, a common antibiotic. They are now using it in an effort to combat multi-resistant tuberculosis, for which existing treatments don’t work. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - February 3, 2017 Category: Biomedical Science Authors: Tashian Myers Tags: Science News chemical and structural biology Elisabeth Campbell immunology RNA polymerase Seth Darst tuberculosis Virology and Microbiology Source Type: news

Study reveals the structure of a protein crucial for DNA replication
For life to propagate, the instructions in our DNA must be copied and passed on to future generations. Focusing on the structure of the machinery that executes this process, scientists have revealed that the orientation of the proteins involved is different from what has previously been reported. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 31, 2017 Category: Biomedical Science Authors: Katie Fenz Tags: Science News CMG helicase cryo-electron microscopy DNA replication Laboratory of DNA Replication Michael O'Donnell structural biology Source Type: news

Discovery helps explain why only some people develop life-threatening dengue infections
After contracting dengue fever once, certain people who encounter the virus again develop much more severe infections. New research identifies an immunological signature that could help identify and better treat these patients. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 31, 2017 Category: Biomedical Science Authors: Wynne Perry Tags: Science News antibody-dependent enhancement dengue Fc region immunology Jeffrey Ravetch Jeffrey V. Ravetch Leonard Wagner Laboratory of Molecular Genetics and Immunology Taia Wang Virology Source Type: news

Rockefeller president Richard P. Lifton releases statement on U.S. immigration policy
In response to an executive order on immigration issued by President Donald J. Trump Friday, Rockefeller University President Richard P. Lifton today released a statement condemning the policy and outlining the detrimental effects it will have on the development of science and technology in the U.S. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 30, 2017 Category: Biomedical Science Authors: Zach Veilleux Tags: Campus News Source Type: news

Researchers explore how protein production gets distorted in skin cancer
Researchers have shown that a shift in translation, the process by which cells produce proteins from RNA, may promote skin cancer. The discovery could potentially aid the development of new treatments. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 27, 2017 Category: Biomedical Science Authors: Tashian Myers Tags: Science News Ataman Sendoel EIF2a Elaine Fuchs Laboratory of Mammalian Cell Biology skin cancer squamous cell carcinoma translation translational regulation Source Type: news

Antibody Combination Puts HIV on the Ropes
Researchers have shown that a combination of three antibody drugs can completely suppress HIV in infected mice. The antibodies were isolated from a patient whose immune system mounted an unusually effective response against the virus. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 25, 2017 Category: Biomedical Science Authors: Tashian Myers Tags: Science News antibody therapy BG1 BG18 HIV Michel Nussenzweig NC37 neutralizing antibodies Source Type: news

Elaine Fuchs wins 2017 McEwen Award for Innovation
Fuchs has received the 2017 McEwen Award for Innovation. The prize, given by the International Society for Stem Cell Research, recognizes outstanding contributions in the fields of stem cell research or regenerative medicine. Fuchs will receive a $100,000 award and present her research at the society’s annual meeting in June. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 23, 2017 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors Elaine Fuchs Laboratory of Mammalian Cell Biology and Development McEwen Award for Innovation Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development Source Type: news

In the News – New York Times – Kronauer
Gene-Modified Ants Shed Light on How Societies Are Organized   “‘Our ultimate goal is to have a fundamental understanding of how a complex biological system works,’ Dr. Kronauer said. ‘I use ants as a model to do this.’ As he … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 23, 2017 Category: Biomedical Science Authors: pubaff Tags: In the News ants Daniel Kronauer Laboratory of Social Evolution social behavior Source Type: news

MacKinnon lab charts the anatomy of three molecular channels
By determining the three-dimensional structures of these molecules down to the level of atoms, the researchers have unlocked key details as to how they function in the body. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 19, 2017 Category: Biomedical Science Authors: Wynne Perry Tags: Science News Chia-Hsueh Lee chloride channel CLC Eunyong Park HCN Laboratory of Neurobiology and Biophysics Richard Hite Roderick MacKinnon Slo2.2 structural and chemical biology Source Type: news

Biophysicist Gregory M. Alushin receives White House honor for early career scientists
Alushin, who recently joined Rockefeller as assistant professor, has been chosen by President Obama as a recipient of the Presidential Early Career Award for Scientists and Engineers. The prestigious award, given annually by the White House, recognizes scientists and engineers who show exceptional potential early on in their careers. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 13, 2017 Category: Biomedical Science Authors: Alexandra MacWade Tags: Awards and Honors Gregory Alushin Gregory M. Alushin Laboratory of Structural Biophysics and Mechanobiology PECASE Presidential Early Career Award Source Type: news

New research offers clues into how the brain shapes perception to control behavior
Some of the visual information our brains receive is potentially misleading. New research on fruit flies demonstrates how even a simple brain can filter out such misinformation, hinting at how our own brains might shape how we see the world—and how we react to it. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 5, 2017 Category: Biomedical Science Authors: Wynne Perry Tags: Science News Anmo Kim Drosophila fruit flies Gaby Maimon Laboratory of Integrative Brain Function neurosciences and behavior vision visual processing visual system Source Type: news

Scientists learn how to ramp up microbes ’ ability to make memories
Researchers have identified a mutation that prompts bacterial cells to acquire genetic memories 100 times more frequently than they do naturally. This discovery provides a powerful research tool and could bring scientists one step closer to developing DNA-based data storage devices. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - January 4, 2017 Category: Biomedical Science Authors: Wynne Perry Tags: Science News biotechnology Cas9 CRISPR I473F immunology Laboratory of Bacteriology Luciano Marraffini microbiology Robert Heler synthetic biology Virology Source Type: news

Research on sweat glands suggests a route to better skin grafts
Scientists have discovered the signaling pathways that help hair follicles and sweat glands form during development, and identified the mechanism that allows both of these features to coexist in human skin. The findings may improve the methods used to grow tissue used in grafting procedures. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 23, 2016 Category: Biomedical Science Authors: Katie Fenz Tags: Science News BMP signaling Elaine Fuchs hair follicles Laboratory of Mammalian Cell Biology and Development skin grafts sweat glands Source Type: news

Researchers develop automated melanoma detector for skin cancer screening
Doctors have trouble diagnosing melanoma because benign moles look very similar to malignant growths. But in developing a new technology that automatically extracts quantitative data from images of melanomas, scientists hope to help doctors detect the disease earlier and avoid unnecessary biopsies. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - December 23, 2016 Category: Biomedical Science Authors: Katie Fenz Tags: Science News automated detection cancer screening imaging biomarker James G. Krueger Laboratory of Investigative Dermatology melanoma Source Type: news