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Research identifies a protein that helps determine the fate of RNA
RNA can be translated into protein or turned into gene-regulating molecules. A newly discovered “reader” recognizes a chemical instruction tag affixed to RNA, an important step in determining the RNA’s destiny. Because of the processes involved, the research has implications for cells’ normal function and disease. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 27, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Claudio Alarcón genetics and genomics Laboratory of Systems Cancer Biology m6A microRNA RNA splicing Sohail Tavazoie Source Type: news

Promising class of new cancer drugs causes memory loss in mice
New research shows that a family of experimental cancer drugs can induce neurological changes in mice. The findings underscore the need for more research to determine whether these compounds can enter the brain, where they potentially might cause side effects such as memory loss. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 24, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News BET inhibitor Brd4 cancer David Allis epigenetics Erica Korb genetics and genomics Memory neurosciences and behavior robert darnell Source Type: news

Expression of a single gene lets scientists easily grow hepatitis C virus in the lab
In devising a method to readily grow hepatitis C in the laboratory, scientists might have overcome a major hurdle for basic research into the virus and the disease it causes. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 19, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Charles Rice HCV hepatitis C immunology microbiology Mohsan Saeed SEC14L2 Virology Source Type: news

A newly discovered molecular feedback process may protect the brain against Alzheimer’s
Researchers have identified within neurons a series of molecular interactions — known as a pathway — that can dampen the production of the Alzheimer’s protein amyloid-β. These results suggest a new route in the search for therapies for this degenerative disease. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 17, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Alzheimer's disease amyloid-β golgi Laboratory of Molecular and Cellular Neuroscience neurosciences and behavior Paul Greengard WAVE1 Yong Kim Source Type: news

Luciano Marraffini and Robert Roeder recognized by ASBMB awards
Marraffini, who studies the adaptive immune systems, known as CRISPR-Cas systems, found in some bacteria and used in genome editing, has won the Earl and Thressa Stadtman Scholar Award. Meanwhile, Robert Roeder, who investigates the mechanisms that regulate transcription, the process by which genes are copied into RNA, is the recipient of the Herbert Tabor Research Award. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 13, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News ASBMB awards and honors Laboratory of Bacteriology Laboratory of Biochemistry and Molecular Biology Luciano Marraffini Robert Roeder Source Type: news

In exploring a fly’s choice of a mate, researchers track the neural circuits that bridge sensory perception and behavioral action
A new study explains how taste and smell signals travel from a male fruit fly’s sense organs and into his higher brain areas as he assesses a potential mating partner. The research may provide important clues about how our brains integrate different sense perceptions to make decisions. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 13, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News courtship circuit Drosophila melanogaster Josie Clowney Laboratory of Neurophysiology and Behavior neurosciences and behavior P1 neuron Vanessa Ruta Source Type: news

New research helps explain why a deadly blood cancer often affects children with malaria
Children in equatorial Africa who suffer from malaria are at high risk of developing Burkitt’s lymphoma, a highly aggressive blood cancer. A new study sheds light on the long-standing mystery of how the two diseases are connected. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 13, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Source Type: news

In the News – Scientist – Nussenzweig
Double-Edged Enzyme   “Rockefeller’s Davide Robbiani, Michel Nussenzweig and colleagues infected wild-type mice with Plasmodium chabaudi, causing long-term malaria-like infections in mice. They found that B-lymphocytes had a potent and long-lasting response and that these cells expressed high levels of … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 13, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News Source Type: news

Obesity researcher and former hospital physician-in-chief Jules Hirsch dies
Hirsch, an early leader in the study of human metabolism, was best known for his work on a landmark study that offered an explanation for why people who lose weight tend to regain it over time. He died at the age of 88. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 12, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News Jules Hirsch metabolism Obesity obituary Rockefeller University Hospital Source Type: news

Agata Smogorzewska, who studies DNA repair, promoted to associate professor
Since arriving in 2009, Smogorzewska has investigated a type of DNA repair that occurs during cell division when cells remove misplaced links between DNA strands. To identify the genes and understand the molecular mechanisms involved, she investigates this repair through the lens of rare genetic disorders. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 11, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News Agata Smogorzewska cell division DNA repair interstrand crosslinks Laboratory of Genome Maintenance promotion Source Type: news

New research sheds light on the molecular origins of Parkinson’s disease
Scientists have identified two proteins that appear to have a protective effect in the set of neurons most affected by this degenerative disease. When the activity of these molecules wanes, disease sets in. This discovery suggests new avenues for preventing or treating Parkinson’s. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 10, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News dopamine neurons Laboratory of Molecular and Cellular Neuroscience Lars Brichta neurodegeneration Parkinson's disease Paul Greengard SNpc VTA Source Type: news

In the News – NY Post – Darnell
Ice Bucket Challenge money distributed to ALS researchers   “In New York, Dr. Robert Darnell is one of the beneficiaries. The New York Genome Center, where he is the president and scientific director, received $2.5 million in challenge money from … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 9, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News Source Type: news

Mutations linked to genetic disorders shed light on a crucial DNA repair pathway
Researchers have identified two new genes in which mutations can interfere with a cell's ability to remove misplaced links between DNA strands, and, as a result, cause a rare genetic disorder known as Fanconi anemia. These discoveries offer new insight on a repair process critical to maintaining certain tissues and preventing cancer. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 7, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Agata Smogorzewska cell division DNA repair Fanconi anemia interstrand crosslinks Laboratory of Genome Maintenance RAD51 UBE2T Source Type: news

Fly brains filter out visual information caused by their own movements, like humans
To cut down on the barrage of sensory information, the human brain ignores input caused by eye movements. Researchers have found a similar process in flies, whose brains mute signals generated by flight turns. This discovery gives researchers a new tool with which to study this silencing process. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - August 3, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Gaby Maimon Laboratory of Integrative Brain Function sensory input silencing mechanism visual perception Source Type: news

Atomic view of cellular pump reveals how bacteria send out proteins
Within the structure of the simple but previously unexamined pump, researchers found a striking feature: a large, water-filled channel, a natural environment for the hydrophilic proteins that must pass through. Their work offers new insight into the mechanics that allow bacteria to manipulate their environments. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - July 22, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News cellular pump David Yin-wei Lin Jue Chen Laboratory of Membrane Biology and Biophysics membrane protein PCAT protein transport Source Type: news