In the News – The Lancet – Dubos
Antibiotic antagonist: the curious career of René Dubos   “Fortunately, Lederberg had been paying attention and in the late 1980s he used his position as head of the Rockefeller University to revive Dubos’s warnings about the mutability and adaptability of … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 18, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News antibiotic resistance gramicidin history Joshua Lederberg Rene Dubos Source Type: news

Mutations in key cancer protein suggest new route to treatments
Researchers found they could disrupt STAT3’s ability to act as a transcription factor and so contribute to the proliferation of cancerous cells, by altering a particular part of the protein. This accomplishment suggests a basis for new, targeted approaches to fighting cancer. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 18, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News cancer chemical and structural biology Claudia Mertens James E. Darnell Laboratory of Molecular Cell Biology sebastian klinge STAT Stat3 Source Type: news

Rockefeller’s newest faculty member investigates how antibodies are made
Gabriel Victora, an immunologist who studies the processes by which the immune system refines its response to an infection, will establish the Laboratory of Lymphocyte Dynamics in September of 2016 where he will study antibody responses at the levels molecules, cells, and whole organs. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 16, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News affinity maturation antibodies Gabriel Victora immunology Laboratory of Lymphocyte Biology new faculty Source Type: news

DNA strands often “wiggle” as part of genetic repair
New research indicates that every time a double-stranded break occurs in DNA strands, the damaged ends move about during repair. Scientists believe a better understanding of this mysterious mechanism could improve the use of cancer treatments, some of which manipulate DNA repair in malignant cells. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 5, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News chemotherapy DNA repair Francisca Lottersberger Laboratory of Cell Biology and Genetics microtubules Taxol telomeres Titia de Lange Source Type: news

In the News – Today – Flajolet
Alzheimer’s was ‘abstract’ until it affected my family   “November is Alzheimer’s Awareness Month, and the Fisher Center at Rockefeller University is on the frontlines of the battle against the disease. Howard Lutnick, who leads the board at the Fisher … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 3, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News Alzheimer's awareness Alzheimer's disease Marc Flajolet Paul Greengard The Fisher Center for Alzheimer's Research Source Type: news

In the News – Newsday – O’Donnell
Researchers at Brookhaven lab, Stony Brook and Rockefeller universities make new discoveries about double helix copying   “In Manhattan, Michael O’Donnell, who heads Rockefeller’s Laboratory of DNA Replication, said the finding will change how students understand DNA replication. ‘It’s a … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 2, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News DNA replication epigenetics Laboratory of DNA Replication Michael O'Donnell replisome structural biology Source Type: news

Study reveals the architecture of the molecular machine that copies DNA
Until now, the exact configuration of the replisome, a block of proteins that unzips the DNA helix and creates two duplicate helices, was unknown. After taking the first complete pictures of it, researchers were surprised to find the complex possesses a counterintuitive architecture, raising new questions about its functions. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 2, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Brain Chait chemical and structural biology DNA replication epigenetics Huilin Li Laboratory of DNA Replication Michael O'Donnell replisome Source Type: news

Researchers examine how a face represents a whole person in the brain
A face is more than a collection of features; it can represent the complete individual. A new brain imaging study shows that parts of a primate face processing system actually prefer faces with bodies, offering new insight into how faces convey this broader social information. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 28, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Clark Fisher face patches facial processing Laboratory of Neural Systems Winrich Freiwald Source Type: news

Discovery of genes involved in inner ear development hints at a way to restore hearing and balance
Scientists have identified two genes crucial to the production of delicate sensors, called hair cells, in mammals. These genes, or others in the same pathway, could be promising targets for efforts to treat hearing loss or balance problems, the scientists suggest. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 26, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News A. James Hudspeth hearing inner ear Ksenia Gnedeva Laboratory of Sensory Neuroscience sox11 sox4 soxC utricle Source Type: news

Researchers explore how a cell’s protein-making factories are assembled
The intricate dynamics of ribosome assembly, an elaborate and carefully coordinated process that happens continuously inside cells, are not yet fully understood. Using a new technique they devised, researchers have mapped out the proteins involved in the early stages of the construction of a ribosome. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 23, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News chemical and structural biology Laboratory of Protein and Nucleic Acid Chemistry Malik Chaker-Margot ribosome sebastian klinge small ribosomal subunit Source Type: news

Researchers identify potential new leukemia drug target
In some cases of acute myeloid leukemia, a mutant protein is known to cause dramatic changes in gene expression. Now researchers have identified a second protein with similar function that plays an even broader role in the disease. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 21, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News acute myeloid leukemia cancer Laboratory of Biochemistry and Molecular Biology Mo Chen Robert Roeder Source Type: news

Jean-Laurent Casanova elected to the National Academy of Medicine
With his election, Casanova, who investigates the genetic underpinnings of unusual vulnerability to specific infectious diseases among young people, receives one of the highest honors within the field of medicine. Seventeen Rockefeller scientists are currently members of the academy of medicine. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 19, 2015 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors Institute of Medicine Jean-Laurent Casanova National Academy of Medicine St. Giles Laboratory of Human Genetics of Infectious Diseases Source Type: news

Helmsley Trust renews $15 million grant for novel digestive disorders research
The funding renewal will support research initiatives within Rockefeller’s interdisciplinary Center for Basic and Translational Research on Disorders of the Digestive System. The center brings together about 20 labs that study a broad range of biological processes related to the digestive system. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 16, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News Barry Coller Barry S. Coller Center for Basic and Translational Research on Disorders of the Digestive System grant Leona M. and Harry B. Helmsley Charitable Trust metabolic disorders Paul Cohen Source Type: news

New faculty member develops light-based tools to study the brain
Alipasha Vaziri, who was appointed a tenure-track associate professor in September, seeks to capture and manipulate interactions among neurons within the living brain. He uses his background in physics to develop innovative ways of recording neural activity quickly and across large areas, all at single-cell resolution. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 15, 2015 Category: Biomedical Science Authors: pubaff Tags: Campus News Alipasha Vaziri new faculty Source Type: news

Two Rockefeller postdocs recognized by Blavatnik Regional Awards
Hani Goodarzi and Ziv Shulman have been named a winner and a finalist, respectively, by the Blavatnik Regional Awards, which honor outstanding postdoctoral scientists in New York, New Jersey, and Connecticut. Goodarzi is a postdoc in Sohail Tavazoie’s lab; Shulman, a former postdoc in Michel Nussenzweig’s lab, has since established his own lab at the Weizmann Institute of Science in Israel. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 13, 2015 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors Blavatnik Awards Blavatnik Awards for Young Scientists Elizabeth and Vincent Meyer Laboratory of Systems Cancer Biology Hani Goodarzi Laboratory of Molecular Immunology Michel C. Nussenzweig Michel Nussenzweig Sohail Tava Source Type: news