Research on the genetic roots of a blood disorder illustrates the challenges in parsing genetic data
Does a particular genetic variation translate into a predisposition to an illness, or is it simply a benign rearrangement of genetic code? Drawing up on genomic data from thousands of people, researchers attempted to answer this question by focusing on mutations in two genes associated with a key receptor in blood clotting. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 14, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Source Type: news

In the News – BBC – Nussenzweig
HIV: new approach against virus “holds promise”   “Michel Nussenzweig of The Rockefeller University told BBC News: ‘This is different to treatment out there already on two counts. First because it comes from a human – so it is natural … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 9, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News AIDS HIV Michel Nussenzweig Source Type: news

In the News – New York Daily News – Nussenzweig
HIV vaccine on the horizon? Rockefeller University researchers call antibody ‘extremely potent’ against virus strains “Researchers working in Dr. Michel Nussenzweig’s Laboratory of Molecular Immunology at Rockefeller University were able to isolate and clone [a] new generation of antibodies, so … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 9, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News AIDS HIV Michel Nussenzweig Source Type: news

In first human study, new antibody therapy shows promise in suppressing HIV infection
In the first results to emerge from HIV patient trials of a new generation of so-called broadly neutralizing antibodies, Rockefeller University researchers have found the experimental therapy can dramatically reduce the amount of virus present in a patient’s blood. The work, reported this week in Nature, brings fresh optimism to the field of HIV immunotherapy and suggests new strategies for fighting or even preventing HIV infection. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 8, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News AIDS broadly neutralizing antibodies clinical trial HIV infectious disease Michel C. Nussenzweig Source Type: news

Under the microscope, strong-swimming swamp bacteria spontaneously organize into crystals
Biophysicists have discovered that fast-swimming, sulfur-eating microbes known as Thiovulum majus can form a two-dimensional lattice of rotating cells. Not only is this the first known example of bacteria spontaneously creating such a pattern, never before have living things been seen to move together in this way. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 6, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Albert Libchaber Alex Petroff collective dynamics hexagonal lattice Laboratory of Experimental Condensed Matter Physics Thiovulum majus Source Type: news

The Rockefeller University designated a “Milestones in Microbiology” site by the American Society for Microbiology
The designation is made in recognition of the many outstanding achievements of Rockefeller scientists, and in particular for ground-breaking discoveries by Oswald T. Avery, Colin M. MacLeod, Maclyn McCarty, Peyton Rous, and Emil C. Gotschlich. It will be formally announced at a dedication ceremony on April 8. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 6, 2015 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors Source Type: news

Intellectual property on pediatric cancer is dedicated to the public
Intellectual property resulting from the discovery of specific DNA mutations linked to a rare and often deadly type of adolescent liver cancer, fibrolamellar hepatocellular carcinoma, has been dedicated to the public by the institutions that made the discovery, The Rockefeller University and the New York Genome Center, in the hope of accelerating progress toward the delivery of diagnostics and therapies for the devastating disease. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 2, 2015 Category: Biomedical Science Authors: pubaff Tags: Public Affairs Source Type: news

Rockefeller ranks first among global universities in several measures of scientific impact
The rankings, released by the European Commission-funded U-Multirank survey, placed Rockefeller among the top five institutions in five key categories. Across the entire set of rankings, which incorporates data from 1,200 institutions, Rockefeller was the only institution to receive this many top slots. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 31, 2015 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors Source Type: news

In the News – NPR – Casanova
A single gene may determine why some people get so sick with the flu “The study helps explain genetic variation changes the way that people fight off viruses. ‘The response to influenza is genetically impaired,’ says [Jean-Laurent] Casanova. He’s hoping … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 27, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News flu influenza Jean-Laurent Casanova pediatric Source Type: news

Genetic mutation helps explain why, in rare cases, flu can kill
A small number of children who catch the influenza virus fall so ill they end up in the hospital even while their family and friends recover easily. New research from Rockefeller helps explain why: a rare genetic mutation that prevents the production of a critical protein, interferon, that is needed to fight off the virus. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 26, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News infectious disease influenza interferon Jean-Laurent Casanova St. Giles Laboratory of Human Genetics of Infectious Diseases Source Type: news

To survive, a parasite mixes and matches its disguises, study suggests
A detailed look at the African sleeping sickness parasite’s strategy for evading its hosts’ immune systems revealed that the blood parasites assume a surprising diversity of protein coat disguises. In fact, the number of disguises necessary to maintain a long-term infection appears to exceed the functional genes that encode them. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 26, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News antigenic variation F. Nina Papavasiliou George Cross Laboratory of Lymphocyte Biology Monical Mugnier parasitic infection sleeping sickness Trypanosoma brucei VSG Source Type: news

Researchers master gene editing technique in mosquito that transmits deadly diseases
Rockefeller University researchers have successfully harnessed a technique, CRISPR-Cas9 editing, to use in an important and understudied species: the mosquito, Aedes aegypti, which infects hundreds of millions of people annually with the deadly diseases chikungunya, yellow fever, and dengue fever. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 26, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News aedes aegypti chikungunya CRISPR CRISPR-Cas9 dengue fever gene editing Laboratory of Neurogenetics and Behavior Leslie B. Vosshall Leslie Vosshall mosquitos yellow fever Source Type: news

In the News – New York Times Dot Earth – Ausubel
Earth’s untallied biological bounty, from L.A. suburbs to deep seabed sediments   “Recent chats with Jesse Ausubel of Rockefeller University drew me this week to remarkable new discoveries of traces of life in sediment layers up to 200 feet beneath … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 25, 2015 Category: Biomedical Science Authors: pubaff Tags: In the News Jesse Ausubel Source Type: news

Chemical tag marks future microRNAs for processing, study shows
New research reveals how cells sort out the RNA molecules destined to become gene-regulating microRNAs by tagging them. Because microRNAs help control processes throughout the body, this discovery has wide-ranging implications for development, health and disease, including cancer. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 24, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News cancer Claudio Alarcón Laboratory of Systems Cancer Biology m6A METTL3 microRNA Sohail Tavazoie Source Type: news

Changes in a blood-based molecular pathway identified in Alzheimer’s disease
Researchers identify a molecular bridge between amyloid-β and chronic inflammation, two hallmarks of Alzheimer's. That bridge, a molecular cascade known as the contact system, suggests the possibility of a simple blood test that could diagnose the disease early and non-invasively. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 20, 2015 Category: Biomedical Science Authors: pubaff Tags: Science News Alzheimer’s disease amyloid-β diagnostic inflammation neurobiology patricia and john rosenwald laboratory of neurobiology and genetics Sidney Strickland Source Type: news