Unraveling the mechanisms that create the individualized metabolism in leukemia
(Kumamoto University) Lysine-specific demethylase 1 (LSD1), an enzyme involved in gene expression, produces individualized metabolism depending on the type of acute myeloid leukemia cells. Cancer cells have a unique ability to metabolize substances differently from normal cells, and this ability is considered to be a promising therapeutic target. New findings may contribute to the safe and effective use of LSD1 inhibitors as potential anticancer agents, and to the development of highly specific treatments for various leukemia types. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: Epithelial-mesenchymal transitions create endothelial cells and tumor growth
(Impact Journals LLC) Cells that have undergone EMT can promote tumor growth and neovascularization either indirectly, by promoting endothelial transdifferentiation of carcinoma cells, or directly, by acquiring an endothelial phenotype, with FOXC2 playing key roles in these processes (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: General anesthesia for pancreatic cancer surgery
(Impact Journals LLC) The major finding of this Oncotarget study was perioperative tryptophan depletion and increased taurine synthesis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: Genome wide DNA methylation landscape reveals glioblastoma's influence
(Impact Journals LLC) These Oncotarget results suggest that GBM might induce epigenetic alterations in tumor infiltrating CD4 T-cells (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2021 Category: Cancer & Oncology Source Type: news
Researchers on a mission to fight deadly childhood cancer
(University of South Australia) Neuroblastoma is the deadliest and most common solid cancer in young children the world over, accounting for 15 per cent of all childhood cancer deaths. But Australian researchers are taking the first steps to find the cause and better treatments for this devastating disease which affects children under the age of five. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 3, 2021 Category: Cancer & Oncology Source Type: news
Cancer: Immunotherapies without side effects?
(Universit é de Gen è ve) Immunotherapy has revolutionized the field of cancer treatment. However, inflammatory reactions in healthy tissues frequently trigger side effects that can be serious. Scientists (UNIGE/Harvard Medical School) have succeeded in establishing the differences between deleterious immune reactions and those targeting tumor cells that are sought after. It appears that while the immune mechanisms are similar, the cell populations involved are different. This work makes it possible to envisage targeted and less dangerous treatments for cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Cancer cells eat themselves to survive
(University of Copenhagen - The Faculty of Health and Medical Sciences) To survive life threatening injuries, cancer cells use a technique in which they eat parts of the membrane surrounding them. This is shown for the first time in research from a team of Danish researchers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
NYUAD study maps nanobody structure, leading to new ways to potentially fight diseases
(New York University) For the first time in the UAE, researchers at NYU Abu Dhabi have used nuclear magnetic resonance techniques to determine the structure of a specific nanobody, Nb23, potentially leading to a better understanding of how this small protein derived from an antibody type, found only in camelids (i.e camels, llamas, and alpacas) and sharks, can fight diseases ranging from rheumatoid arthritis, lupus and psoriasis to lymphoma and breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Poorer survival in obese colorectal cancer patients possibly linked to lower chemotherapy doses
(European Society for Medical Oncology) Obese patients with colorectal cancer receive lower cumulative doses of adjuvant chemotherapy, relative to their body surface area (BSA), than non-obese patients, show results from a large meta-analysis reported at the ESMO World Congress on Gastrointestinal Cancer 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Bowel cancer data reinforce need to reduce unnecessary antibiotic use
(European Society for Medical Oncology) Doctors and patients are being advised to reduce unnecessary antibiotic use following new data suggesting that these medicines may increase the risk of cancer of the large intestine (colon), especially in people under 50 years. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: Loss of CPAP in oral cancer
(Impact Journals LLC) CPAP also plays a vital role in suppressing tumorigenesis in OSCC by facilitating EGFR homeostasis (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Closer to cure: New imaging method tracks cancer treatment efficacy in preclinical studies
(The National Institutes for Quantum and Radiological Science and Technology) Several cancers grow through immunosuppression, making immunotherapy a promising approach to treating cancers. But several approaches against one highly sought-after target molecule for such treatment have failed in late stage clinical trials. To find out why, scientists will need to study what happens to the target molecule over time once the treatment is administered. Now, in a game-changer for this field, a team from Japan has discovered a new PET-imaging-based method to achieve this tracking. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2021 Category: Cancer & Oncology Source Type: news
Multimodality care improves treatment outcomes for aggressive prostate cancer
(University of California - Los Angeles Health Sciences) Men with high-risk prostate cancer with at least one additional aggressive feature have the best outcomes when treated with multiple healthcare disciplines, known as multimodality care, according to a UCLA study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 1, 2021 Category: Cancer & Oncology Source Type: news
Blood test for personalized cancer treatment
(Flinders University) A blood test to help guide the treatment of esophageal, stomach and bowel cancers will be evaluated in a new Flinders University trial set to get underway. The trial is thanks to a federal government grant of almost $2 million announced yesterday, with Flinders University awarded funding for three projects, totaling $5.8 million. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 1, 2021 Category: Cancer & Oncology Source Type: news
Online symposium addresses issues of cancer research and palliative care
(Leopoldina) Why does pancreatic cancer develop, what new therapies might be effective against metastasis formation, and what is to be considered in palliative care? Members of the German National Academy of Sciences Leopoldina will address these questions at the virtual symposium of Class III Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 1, 2021 Category: Cancer & Oncology Source Type: news
