Kurome Therapeutics closes $15 million Series A financing
(CincyTech) The funding will support the pre-clinical advancement of dual IRAK1/4 and panFLT3 inhibitors to target cancer cells that evade the effects of both targeted therapy and chemotherapy drugs via adaptive resistance mechanisms, having co-opted IRAK1/4-mediated immune signaling pathways to survive. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2021 Category: Cancer & Oncology Source Type: news
Case study shows patient on ketogenic diet living fully with IDH1-mutant glioblastoma
(Boston College) Ketogenic metabolic therapy has been shown to successfully starve cancer cells of the glucose and glutamine they need to survive. In a new case study, a British man who rejected the standard of care to treat his glioblastoma has lived for more than 80 months with the typically fatal tumor after adopting a ketogenic diet, researchers report in the journal Frontiers in Nutrition (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2021 Category: Cancer & Oncology Source Type: news
Drug commonly used as antidepressant helps fight cancer in mice
(University of California - Los Angeles Health Sciences) A new study by UCLA researchers suggests that the group of antidepressants commonly known as MAOIs may help the immune system attack cancer. Their findings are reported in two papers, which are published in the journals Science Immunology and Nature Communications. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2021 Category: Cancer & Oncology Source Type: news
Targeted therapy pralsetinib safely effectively treats lung and thyroid cancers with RET alterations
(University of Texas M. D. Anderson Cancer Center) Results from the multi-cohort Phase I/II ARROW clinical trial, conducted by The University of Texas MD Anderson Cancer Center researchers, showed that a once-daily dose of pralsetinib, a highly selective RET inhibitor, was safe and effective in treating patients with advanced RET fusion-positive non-small cell lung cancer (NSCLC) and RET-altered thyroid cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Turning the heat on: A flexible device for localized heat treatment of living tissues
(Tokyo Institute of Technology) Combining thermotherapy with other treatment modalities can improve the treatment's effectiveness. However, there is a dearth of suitable heat-generating wireless devices that can be implanted in the patient's body enabling greater flexibility and ease of treatment. Recently, researchers at Tokyo Institute of Technology (Tokyo Tech) have invented a unique induction-based flexible heating device that can address these gaps. The study has been published in the journal Advanced Functional Materials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Diagnoses with Deepflash
(University of W ü rzburg) Microscopic images of tissue sections can now be analyzed much more easily - with an innovative digital tool. Two researchers from W ü rzburg have received three awards for this. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Study shows new links between high fat diets and colon cancer
(Arizona State University) A new ASU study led by Miyeko Mana and her team has shown in greater detail than ever before of how high fat diets can trigger a molecular cascade of events that leads to intestinal and colon cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
A new bacteria, made in Belgium (and UCLouvain)
(Universit é catholique de Louvain) Researchers from University of Louvain have discovered a new bacterium in the human intestine, they called Dysosmobacter welbionis.The UCLouvain scientists have also discovered positive effects of this bacterium on type 2 diabetes, obesity and inflammation.The originality of this discovery? It is extremely rare that a single research team identifies, cultivates, names a bacterium and then reveals its action in the human body, a first in Belgium and published in the prestigious journal Gut. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: Anti-hormonal treatment eligibility in granulosa cell tumors of the ovary
(Impact Journals LLC) Granulosa cell tumors are a well-defined ovarian cancer subtype, responsible for 2-5% of ovarian malignancies with an annual incidence of 0.6-1.0 per 100.000 women worldwide. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Cholesterol metabolite induces production of cancer-promoting vesicles
(University of Illinois at Urbana-Champaign, News Bureau) Scientists studying the link between cholesterol and breast cancer report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound compartments called extracellular vesicles. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 9, 2021 Category: Cancer & Oncology Source Type: news
Finding the weak points in radiation-resistant pancreatic cancer cells
(The National Institutes for Quantum and Radiological Science and Technology) Pancreatic cancer is one of the deadliest cancer subtypes not just because it is difficult to diagnose early, but because it is inherently resistant to chemotherapy and radiotherapy. In a recent study, scientists from Japan investigated the relationship that exists between the radiation resistance of pancreatic cancer cells, the natural cell cycle, and a cellular mechanism called autophagy, or " self-digestion. " Their results pave the way for novel radiosensitizers and improved therapeutic strategies for resistant cancers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 8, 2021 Category: Cancer & Oncology Source Type: news
Are heavy metals toxic? Scientists find surprising new clues in yeast
(DOE/Lawrence Berkeley National Laboratory) Scientists at Berkeley Lab and UC Berkeley have compiled the most complete library yet of lanthanide heavy metals and their potential toxicity -- by exposing baker's yeast to lanthanides. Their findings could help researchers uncover hidden pathways between lanthanide metals and disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news
Diets that promote inflammation could increase breast cancer risk
(American Society for Nutrition) A new study of more than 350,000 women found that women with diets incorporating more foods that increase inflammation in the body had a 12% increase in their risk of breast cancer compared to women who consume more anti-inflammatory diets. The new findings are being presented at NUTRITION 2021 LIVE ONLINE. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news
Analysis reveals how kidney cancer develops and responds to treatment
(Michigan Medicine - University of Michigan) By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells from which different subtypes originate, the pathways involved and how the tumor microenvironment impacts cancer development and response to treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news
NIH grant boosts computational search for cancer drugs
(Rice University) Rice computer scientist Lydia Kavraki won an NIH grant to create a data science-based proteomics toolkit to analyze protein-ligand interactions for new cancer therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 7, 2021 Category: Cancer & Oncology Source Type: news
