'Tumor avatars' predict patients' response to immunotherapy
(Netherlands Cancer Institute) Tumor fragments in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. " We've solved a major problem many scientists had been facing: preserving a tumors original composition and structure outside of the patient in the lab " , says cancer researcher Daniela Thommen from the Netherlands Cancer Institute. On 8 July, the results of her study are published in Nature Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Can leukemia in children with Down syndrome be prevented?
(University Health Network) For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Study identifies gut microbes associated with toxicity to combined checkpoint inhibitors in melanoma patients
(University of Texas M. D. Anderson Cancer Center) Researchers from The University of Texas MD Anderson Cancer Center found specific intestinal microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
American Society for Radiation Oncology (ASTRO) to host Annual Meeting in Chicago 10/24-27
(American Society for Radiation Oncology) Registration opens today for the American Society for Radiation Oncology's (ASTRO) 63rd Annual Meeting, which will return to an in-person conference at McCormick Place West in Chicago, October 24-27, 2021. Media resources and registration are available at www.astro.org/astro2021press, and general registration is available at www.astro.org/annualmeeting. The ASTRO Annual Meeting will be the first major medical conference held in Chicago since the start of the COVID-19 pandemic. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Potential marker for success of immunotherapy in the treatment of lung cancer
(Medical University of Vienna) Lung cancer has the highest mortality rate of all cancers, and treatment options are extremely limited, especially for patients with oncogenic mutations in the KRAS gene. Some patients respond very well to treatment with immune checkpoint inhibitors while it is completely ineffective in others. A MedUni Vienna research group identified a potential marker for the success of immunotherapy in lung cancer patients and explained the underlying molecular processes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Study sheds light on mechanism of liposome accumulation in tumors
(University of Colorado Anschutz Medical Campus) Dmitri Simberg, PhD, associate professor in the University of Colorado Skaggs School of Pharmacy, released the results of a study of the effectiveness of different types of fluorescent labels used to monitor the accumulation of liposomes in tumors. The study, titled " Liposomal Extravasation and Accumulation in Tumors as Studied by Fluorescence Microscopy and Imaging Depend on the Fluorescent Label, " was published on July 1, 2021, in the journal of the American Chemical Society, ACS Nano. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Research reveals structure of nanomachine that assembles a cell's energy control system
(University of Sussex) Researchers from the University of Sussex have determined the structure of a tiny multi-protein biological machine, furthering our understanding of human cells and helping to enhance research into cancer, neurodegeneration and other illnesses. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
Director of CU Cancer Center's Animal Imaging honored for contributions to the field
(University of Colorado Anschutz Medical Campus) Overseeing an array of state-of-the-art equipment dedicated to magnetic resonance imaging (MRI), optical imaging, CT and PET, metabolomics, irradiation, and more, Serkova has, over the past 19 years, turned the CU resource into one of the most advanced animal imaging centers in the Rocky Mountain region. In May, she received a 2021 Senior Fellow Award of the International Society of Magnetic Resonance in Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2021 Category: Cancer & Oncology Source Type: news
New model aims to promote better-adapted bladder cancer treatment in the future
(Uppsala University) Uppsala University scientists have designed a new mouse model that facilitates study of factors contributing to the progression of human bladder cancer and of immune-system activation when the tumour is growing. Using this model, they have been able to study how proteins change before, while and after a tumour develops in the bladder wall. The study has now been published in the scientific journal PLOS ONE. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
Tool helps predicts who will respond best to targeted prostate cancer therapy
(University of California - Los Angeles Health Sciences) A new prognostic tool helps predict which men with advanced metastatic prostate cancer will respond favorably to a novel targeted therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
Triple-negative breast cancer metastases in lungs contain more diverse cells than those in liver
(American Association for the Advancement of Science) Metastatic tumors originating from notoriously aggressive triple-negative breast cancer that emerge in the lungs contain a more diverse array of cancer cells than those that arise in the liver, according to a new study in mice and organs from deceased cancer patients. The study also identified a set of genes that distinguish lung and liver metastases; together, the (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
Metabolic enzyme promotes neuroblastoma aggressiveness
(Boston University School of Medicine) High-risk neuroblastoma is an aggressive childhood cancer with poor treatment outcomes. Despite intensive chemotherapy and radiotherapy, less than 50 percent of these children survive for five years. While the genetics of human neuroblastoma have been extensively studied, actionable therapeutics are limited. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
Oncotarget: miRNA signatures from epidermal growth factor inhibitor patients
(Impact Journals LLC) This Oncotarget study suggests that miR-21, miR-31 and miR-520e expression might be a treatment dependent marker for EGFRI induced skin rash. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
New generation anti-cancer drug shows promise for children with brain tumors
(Walter and Eliza Hall Institute) A genetic map of an aggressive childhood brain tumour called medulloblastoma has helped researchers identify a new generation anti-cancer drug that can be repurposed as an effective treatment for the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
Anti-androgen therapy can fuel spread of bone tumours in advanced prostate cancer
(Queensland University of Technology) Anti-androgen therapy is commonly used to treat patients with advanced prostate cancer at stages where the disease has spread to the bones. However, new research has found that anti-androgen treatment can actually facilitate prostate cancer cells to adapt and grow in the bone tumour microenvironment model, which has been developed by QUT biomedical scientists led by Dr Nathalie Bock. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 7, 2021 Category: Cancer & Oncology Source Type: news
