Scientists provide new insight on how to stop transcription of cancer cells
(University of California - Los Angeles Health Sciences) Findings could help pave the way for cancer therapies that target TAF12, potentially stopping transcription in cancer cells and helping decrease the growth of cancerous tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

New approach eradicates breast cancer in mice
(University of Illinois at Urbana-Champaign, News Bureau) A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

Study: Ibrutinib effective treatment for difficult to treat forms of hairy cell leukemia
(Ohio State University Wexner Medical Center) The oral targeted therapy drug ibrutinib is an effective treatment option for high-risk hairy cell leukemia, according to a new study conducted by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

Hundreds of chemicals, many in consumer products, could increase breast cancer risk
(Silent Spring Institute) a new study shows that several hundred common chemicals, including pesticides, ingredients in consumer products, food additives, and drinking water contaminants, could increase the risk of breast cancer by causing cells in breast tissue to produce more of the hormones estrogen or progesterone. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

Scientists identify protein markers related to the most common form of leukemia
(Wiley) Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. New research published in the Journal of Leukocyte Biology reveals that certain protein markers may indicate which patients have stable forms of CLL and which have more aggressive types. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: Subtypes of thymic epithelial tumors independent of WHO type
(Impact Journals LLC) These Oncotarget results may reflect the unselected patient population enrolled in these studies, including no selection for WHO histologic subtype or molecular aberrations. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 21, 2021 Category: Cancer & Oncology Source Type: news

Study identifies MET amplification as driver for some non-small cell lung cancers
(University of Colorado Anschutz Medical Campus) A study led by CU Cancer Center member D. Ross Camidge, MD, PhD, has helped define MET amplification as an actionable driver for some non-small cell lung cancers (NSCLC). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 20, 2021 Category: Cancer & Oncology Source Type: news

Mark Foundation funds Jackson Laboratory scientists to study immunotherapy side effects
(The Mark Foundation for Cancer Research) The Mark Foundation for Cancer Research announces a $1 million grant to The Jackson Laboratory to study the relationship between genetics and the harmful side effects of cancer immunotherapy using mice engineered with humanized immune systems. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 20, 2021 Category: Cancer & Oncology Source Type: news

Preparing T cells for the long haul
(La Jolla Institute for Immunology) In a new Nature Immunology study, researchers at La Jolla Institute for Immunology (LJI) report that T cells can be engineered to clear tumors without succumbing to T cell exhaustion. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Researchers discover how cancer cells that spread to lymph nodes avoid immune destruction
(Massachusetts General Hospital) New research provides insights on why cancer cells that spread to lymph nodes can often avoid being eliminated by immune cells. The blood pressure drug losartan may help overcome this immune evasion. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Why identical mutations cause different types of cancer
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium (DKTK), the Technical University of Munich (TUM), and the University Medical Center G รถ ttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: Cutaneous apocrine sweat gland carcinoma
(Impact Journals LLC) Together these Oncotarget results describe the first ever CAC case with a BRCAness genetic background. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: Caspase-11 and AIM2 inflammasome involved in COPD and lung adenocarcinoma
(Impact Journals LLC) The Oncotarget authors found that AIM2 inflammasome is at the crossroad between COPD and lung cancer in that its higher presence is correlated to lower survival rate of smoking COPD adenocarcinoma patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Oncotarget: Biomechanics in response to drug in hypoxia by atomic force spectroscopy
(Impact Journals LLC) These Oncotarget results show that a degree of chemotherapeutic drug effects on biomechanical and biophysical properties of cancer cells is distinguishable in normoxia and hypoxia` (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news

Personalized immunotherapy response studied in body-on-a-chip cancer models
(Wake Forest Baptist Medical Center) Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 19, 2021 Category: Cancer & Oncology Source Type: news