Computational Approaches to Anesthetic Drug Discovery
Publication date: Available online 14 October 2019Source: Trends in Pharmacological SciencesAuthor(s): Megan McGrath, Andrea Pence, Douglas E. RainesAll currently available general anesthetics produce potentially deadly side effects. Unfortunately, few approaches have been developed to design safer ones, despite important advances in anesthetic mechanisms research. Cayla and colleagues recently showed that computational methods can be used to identify anesthetic lead compounds devoid of specific side effects. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - October 15, 2019 Category: Drugs & Pharmacology Source Type: research
You Cannot Have Your Synergy and Efficacy Too
We present examples of the trade-off in drug combinations used in hepatitis C, HIV, and cancer therapies and believe that screens for optimal drug combinations that presently seek to maximize synergy may be improved by considering the trade-off. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - October 12, 2019 Category: Drugs & Pharmacology Source Type: research
Advances and Challenges in Rational Drug Design for SLCs
Publication date: Available online 10 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Rachel-Ann A. Garibsingh, Avner SchlessingerThere are over 420 human solute carrier (SLC) transporters from 65 families that are expressed ubiquitously in the body. The SLCs mediate the movement of ions, drugs, and metabolites across membranes and their dysfunction has been associated with a variety of diseases, such as diabetes, cancer, and central nervous system (CNS) disorders. Thus, SLCs are emerging as important targets for therapeutic intervention. Recent technological advances in experimental and computational bi...
Source: Trends in Pharmacological Sciences - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics
Publication date: Available online 9 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Saketh S. Dinavahi, Christopher G. Bazewicz, Raghavendra Gowda, Gavin P. RobertsonAldehyde dehydrogenases (ALDHs) are highly expressed in the chemotherapy- and radiotherapy-resistant cell subpopulations of many different cancer types. Accordingly, the development of ALDH inhibitors may be the most direct approach to target these cell populations. However, inhibiting multiple ALDH family members can be toxic and isoform-specific inhibition is often ineffective. This review discusses the role of ALDH in cancer and therapy ...
Source: Trends in Pharmacological Sciences - September 11, 2019 Category: Drugs & Pharmacology Source Type: research
A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis
We describe and exemplify four fundamental approaches to the generation and utilization of metabotype data via multiparametric measurement of (i) metabolite levels, (ii) metabolic trajectories, (iii) metabolic entropies, and (iv) metabolic networks and correlations in space and time. This conceptual framework can underpin metabotyping in the scenario of personalized medicine, with the aim of improving clinical outcomes for patients, but the framework will have value and utility in areas of metabolic profiling well beyond this exemplar. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - September 9, 2019 Category: Drugs & Pharmacology Source Type: research
Towards Targeting the Urotensinergic System: Overview and Challenges
Publication date: Available online 6 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Hassan Nassour, Mustapha Iddir, David ChatenetThe urotensinergic system, comprised of a G protein-coupled receptor (UT) and two endogenous ligands named urotensin II (UII) and urotensin II-related peptide (URP), has garnered significant attention due to its involvement in the initiation and/or the evolution of various diseases. Accordingly, multiple studies using animal models have demonstrated that UT antagonists may have utility as potential therapeutic agents for treating atherosclerosis, pulmonary arterial hypertensi...
Source: Trends in Pharmacological Sciences - September 7, 2019 Category: Drugs & Pharmacology Source Type: research
The Sodium Channel Voltage Sensor Slides to Rest
Publication date: Available online 5 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Vladimir Yarov-Yarovoy, Paul DeCaenVoltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al. have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - September 6, 2019 Category: Drugs & Pharmacology Source Type: research
Opportunities for Electroceuticals in Epilepsy
Publication date: Available online 5 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Omid Kavehei, Tara Julia Hamilton, Nhan Duy Truong, Armin NikpourEpilepsy is a neurological disorder that affects ~1% of the world population. Nearly 30% of epilepsy patients suffer from pharmacoresistant epilepsy that cannot be treated with antiepileptic drugs. Depending on seizure type, a diverse range of therapies are available, including surgery, vagus nerve stimulation, and deep brain stimulation. We review the sensing and stimulation technologies most used in neurological disorders, and provide a vision of minimall...
Source: Trends in Pharmacological Sciences - September 6, 2019 Category: Drugs & Pharmacology Source Type: research
Drug Delivery with Designed Peptide Assemblies
Publication date: Available online 4 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Matthew J. Sis, Matthew J. WebberSelf-assembly of designed synthetic peptides is a versatile strategy to generate functional materials for many applications. Given the biological relevance of their amino acid composition, one logical application for this class of materials lies in drug and therapeutic delivery. Peptide design alters the ultimate device form factor, ranging from circulating nanostructures to locally applied hydrogel depots. This growing field has progressed recently from methods for the simple solubilizat...
Source: Trends in Pharmacological Sciences - September 5, 2019 Category: Drugs & Pharmacology Source Type: research
Interleukin-13 Is Unlucky for Allergy Sufferers
Publication date: Available online 5 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Markus M. Xie, Alexander L. DentAnaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - September 5, 2019 Category: Drugs & Pharmacology Source Type: research
Alport Syndrome Therapeutics: Ready for Prime-Time Players
Publication date: Available online 24 August 2019Source: Trends in Pharmacological SciencesAuthor(s): Kohei Omachi, Jeffrey H. MinerAlport syndrome (AS), a rare disease of basement membrane type IV collagen, impacts the kidneys, ears, and eyes. In severe cases, kidney failure occurs during adolescence or early adulthood, so most research has focused on remedies for kidney dysfunction. Planned and ongoing clinical studies using targets and therapeutic approaches discussed herein provide new hope for AS patients. The outcomes of these trials could suggest new treatments for more common forms of chronic kidney disease (CKD), ...
Source: Trends in Pharmacological Sciences - August 25, 2019 Category: Drugs & Pharmacology Source Type: research
Advancing Drug Discovery via Artificial Intelligence: (Trends in Pharmacological Sciences 40, 592–604; 2019)
Publication date: Available online 23 August 2019Source: Trends in Pharmacological SciencesAuthor(s): H.C. Stephen Chan, Hanbin Shan, Thamani Dahoun, Horst Vogel, Shuguang Yuan (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - August 24, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board and Contents
Publication date: September 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 9Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - August 23, 2019 Category: Drugs & Pharmacology Source Type: research
Subscription and Copyright Information
Publication date: September 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 9Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - August 23, 2019 Category: Drugs & Pharmacology Source Type: research
Striving Towards the Perfect In Vitro Oral Drug Absorption Model
Publication date: Available online 16 August 2019Source: Trends in Pharmacological SciencesAuthor(s): John P. Gleeson, Fiona McCartneyOral drug delivery systems have multiple goals, assessing and enabling intestinal absorption at efficacious doses being one of them. Here we highlight the in vitro advances in modeling drug absorption, which more faithfully reflect human intestinal physiology and reduce the reliance on animal models. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - August 16, 2019 Category: Drugs & Pharmacology Source Type: research
