The Sodium Channel Voltage Sensor Slides to Rest

Publication date: Available online 5 September 2019Source: Trends in Pharmacological SciencesAuthor(s): Vladimir Yarov-Yarovoy, Paul DeCaenVoltage-gated sodium channels (Navs) initiate the action potential waveforms in excitable cells. The molecular mechanisms controlling this process have been actively debated. New prokaryotic Nav structures by Wisedchaisri et al. have completed our understanding of the molecular conformations required for cellular electrical signaling, and provide key templates for research to examine eukaryotic Navs.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research