Subscription and Copyright Information
Publication date: May 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 5Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - April 19, 2019 Category: Drugs & Pharmacology Source Type: research
Rethinking Alkylating(-Like) Agents for Solid Tumor Management
Publication date: Available online 9 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Hélène Lajous, Bénédicte Lelièvre, Elodie Vauléon, Philippe Lecomte, Emmanuel GarcionAlthough old molecules, alkylating agents and platinum derivatives are still widely used in the treatment of various solid tumors. However, systemic toxicity and cellular resistance mechanisms impede their efficacy. Innovative strategies, including local administration, optimization of treatment schedule/dosage, synergistic combinations, and the encapsulation of bioactive molecules in smart, multifunctional drug delivery systems, have ...
Source: Trends in Pharmacological Sciences - April 10, 2019 Category: Drugs & Pharmacology Source Type: research
Unexpected Synergy Reveals New Therapeutic Strategy in SCLC
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Benjamin J. Drapkin, Anna F. FaragoDNA damage repair (DDR) inhibition and immune checkpoint blockade (ICB) have each individually shown modest clinical activity in small cell lung cancer (SCLC). Recently, Sen and colleagues (Cancer Discov. 2019;https://doi.org/10.1158/2159-8290.CD-18-1020) demonstrated that DDR inhibition can activate the stimulator of interferon genes (STING) innate immune pathway, providing strong rationale for combining DDR inhibition and ICB to treat SCLC. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - April 9, 2019 Category: Drugs & Pharmacology Source Type: research
Triptolide and Its Derivatives as Cancer Therapies
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Pawan Noel, Daniel D. Von Hoff, Ashok K. Saluja, Mohana Velagapudi, Erkut Borazanci, Haiyong HanTriptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor, immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor solubility, bioavailability, and toxicity. Recently, Minnelide, a water-soluble prodrug of triptolide, was shown to have potent antitumor activity in various preclinical cancer models. Minnelide is currently in Phase II clinical trials for treatmen...
Source: Trends in Pharmacological Sciences - April 9, 2019 Category: Drugs & Pharmacology Source Type: research
Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery
Publication date: Available online 5 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Edin Muratspahić, Michael Freissmuth, Christian W. GruberG protein-coupled receptors (GPCRs) represent important drug targets, as they regulate pivotal physiological processes and they have proved to be readily druggable. Natural products have been and continue to be amongst the most valuable sources for drug discovery and development. Here, we surveyed small molecules and (poly-)peptides derived from plants, animals, fungi, and bacteria, which modulate GPCR signaling. Among naturally occurring compounds, peptides from plan...
Source: Trends in Pharmacological Sciences - April 6, 2019 Category: Drugs & Pharmacology Source Type: research
