40 Years of Trends in Pharmacological Sciences: Blending Man and Machine
Publication date: Available online 11 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Kusumika Mukherjee (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - July 12, 2019 Category: Drugs & Pharmacology Source Type: research
Deep Aging Clocks: The Emergence of AI-Based Biomarkers of Aging and Longevity
Publication date: Available online 3 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Alex Zhavoronkov, Polina MamoshinaFirst published in 2016, predictors of chronological and biological age developed using deep learning (DL) are rapidly gaining popularity in the aging research community. These deep aging clocks can be used in a broad range of applications in the pharmaceutical industry, spanning target identification, drug discovery, data economics, and synthetic patient data generation. We provide here a brief overview of recent advances in this important subset, or perhaps superset, of aging clocks that ha...
Source: Trends in Pharmacological Sciences - July 5, 2019 Category: Drugs & Pharmacology Source Type: research
Artificial Intelligence: A Novel Approach for Drug Discovery
Publication date: Available online 3 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Óscar Díaz, James A.R. Dalton, Jesús GiraldoMolecular dynamics (MD) simulations can mechanistically explain receptor function. However, the enormous data sets that they may imply can be a hurdle. Plante and colleagues (Molecules, 2019) recently described a machine learning approach to the analysis of MD simulations. The approach successfully classified ligands and identified functional receptor motifs and thus it seems promising for mechanism-based drug discovery. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - July 5, 2019 Category: Drugs & Pharmacology Source Type: research
Max-imizing the Attenuation of Myc Using Small Molecules
Publication date: Available online 4 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Shelton R. Boyd, Damian W. YoungIt has been a widely held notion within the biomedical research community that the reliable modulation of transcription factors with small molecules would represent a holy grail, given their role in directly potentiating oncogenic programs. Among the transcription factors that have been held in highest regard is Myc, since its dysregulation is among the most recurrent events in human cancer. Despite intense efforts, the ability to identify compounds that bind directly to Myc, resulting in its f...
Source: Trends in Pharmacological Sciences - July 5, 2019 Category: Drugs & Pharmacology Source Type: research
The Missing Pieces of Artificial Intelligence in Medicine
Publication date: Available online 2 July 2019Source: Trends in Pharmacological SciencesAuthor(s): Coryandar Gilvary, Neel Madhukar, Jamal Elkhader, Olivier ElementoStakeholders across the entire healthcare chain are looking to incorporate artificial intelligence (AI) into their decision-making process. From early-stage drug discovery to clinical decision support systems, we have seen examples of how AI can improve efficiency and decrease costs. In this Opinion, we discuss some of the key factors that should be prioritized to enable the successful integration of AI across the healthcare value chain. In particular, we belie...
Source: Trends in Pharmacological Sciences - July 3, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board
Publication date: July 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 7Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - June 21, 2019 Category: Drugs & Pharmacology Source Type: research
The Vast Structural Diversity of Antimicrobial Peptides
Publication date: July 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 7Author(s): Johannes Koehbach, David J. CraikAntimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense. They have diverse structures and target a variety of organisms, both by nonspecific membrane interactions and via specific targets. Here we discuss the structures of AMPs from the four main classes currently recognized – that is, peptides with (i) α-helical, (ii) β-sheet, (iii) αβ, or (iv) non-αβ elements – as well as the growing pool of complex topologies including various post-translation...
Source: Trends in Pharmacological Sciences - June 21, 2019 Category: Drugs & Pharmacology Source Type: research
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Publication date: July 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 7Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - June 21, 2019 Category: Drugs & Pharmacology Source Type: research
Artificial Intelligence for Pharma: Time for Internal Investment
Publication date: Available online 13 June 2019Source: Trends in Pharmacological SciencesAuthor(s): Peter V. HenstockArtificial intelligence (AI) has achieved human-level capabilities and continues to rapidly improve. For the pharmaceutical industry, AI can improve decision-making and transform the quest for better medicines. The keys are investing in data management and in internal AI talent who can create value by leveraging corporate data to tackle crucial business problems. (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - June 14, 2019 Category: Drugs & Pharmacology Source Type: research
Predicting and Understanding the Human Microbiome’s Impact on Pharmacology
Publication date: Available online 3 June 2019Source: Trends in Pharmacological SciencesAuthor(s): Reese Hitchings, Libusha KellyOur bodies each possess a unique and dynamic collection of microbes and viruses, collectively the ‘microbiome’, with distinct metabolic capacities from our human cells. Unforeseen modification of drugs by the microbiome can drastically alter their clinical effectiveness, with the most dramatic cases leading to fatal drug interactions. Pharmaceuticals can be activated, deactivated, toxified, or release metabolites that alter the ‘canonical’ pharmacokinetics of the drug. Thus, predicting an...
Source: Trends in Pharmacological Sciences - June 4, 2019 Category: Drugs & Pharmacology Source Type: research
Genetic Insights for Drug Development in NAFLD
Publication date: Available online 31 May 2019Source: Trends in Pharmacological SciencesAuthor(s): Mohammed Eslam, Jacob GeorgeDrug development is a costly, time-consuming, and challenging endeavour, with only a few agents reaching the threshold of approval for clinical use. Therefore, approaches to more efficiently identify targets that are likely to translate to clinical benefit are required. Interrogation of the human genome in large patient cohorts has rapidly advanced our knowledge of the genetic architecture and underlying mechanisms of many diseases, including nonalcoholic fatty liver disease (NAFLD). There are no a...
Source: Trends in Pharmacological Sciences - June 1, 2019 Category: Drugs & Pharmacology Source Type: research
Editorial Board and Contents
Publication date: June 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 6Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - May 31, 2019 Category: Drugs & Pharmacology Source Type: research
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Publication date: June 2019Source: Trends in Pharmacological Sciences, Volume 40, Issue 6Author(s): (Source: Trends in Pharmacological Sciences)
Source: Trends in Pharmacological Sciences - May 31, 2019 Category: Drugs & Pharmacology Source Type: research
Thiol-Based Drugs in Pulmonary Medicine: Much More than Mucolytics
Publication date: Available online 27 May 2019Source: Trends in Pharmacological SciencesAuthor(s): Mario Cazzola, Luigino Calzetta, Clive Page, Paola Rogliani, Maria Gabriella MateraThiol-based drugs are considered as mucolytics because they decrease the viscosity and mostly decrease the elasticity of bronchial secretions by reducing disulfide bonds in proteins. However, they can also act as antioxidant drugs directly through free sulfhydryl groups that serve as a source of reducing equivalents, as well as indirectly through the replenishment of intracellular glutathione (GSH) levels. Modulation of neurokinin A levels may ...
Source: Trends in Pharmacological Sciences - May 28, 2019 Category: Drugs & Pharmacology Source Type: research
Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery
Publication date: Available online 27 May 2019Source: Trends in Pharmacological SciencesAuthor(s): Hugh C. Hemmings, Paul M. Riegelhaupt, Max B. Kelz, Ken Solt, Roderic G. Eckenhoff, Beverley A. Orser, Peter A. GoldsteinSignificant progress has been made in the 21st century towards a comprehensive understanding of the mechanisms of action of general anesthetics, coincident with progress in structural biology and molecular, cellular, and systems neuroscience. This review summarizes important new findings that include target identification through structural determination of anesthetic binding sites, details of receptors and...
Source: Trends in Pharmacological Sciences - May 27, 2019 Category: Drugs & Pharmacology Source Type: research
