A Unified Conceptual Framework for Metabolic Phenotyping in Diagnosis and Prognosis

We describe and exemplify four fundamental approaches to the generation and utilization of metabotype data via multiparametric measurement of (i) metabolite levels, (ii) metabolic trajectories, (iii) metabolic entropies, and (iv) metabolic networks and correlations in space and time. This conceptual framework can underpin metabotyping in the scenario of personalized medicine, with the aim of improving clinical outcomes for patients, but the framework will have value and utility in areas of metabolic profiling well beyond this exemplar.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research