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Performance of the eclipse monitor unit objective tool utilizing volumetric modulated arc therapy for rectal cancer
ConclusionsA 10% reduction in the MU number could be obtained without an alteration of PTV coverage and OARs doses for rectal cancer. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 26, 2019 Category: Cancer & Oncology Source Type: research

Investigation of the changes in the prostate, bladder, and rectal wall sizes during external beam radiotherapy
ConclusionsThe volume of the bladder wall decreased during IMRT. The range of subtraction of the volume of the bladder wall was extensive. Thus, the estimation of the bladder wall may be useful to reduce the inter-fraction variation. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 23, 2019 Category: Cancer & Oncology Source Type: research

Radiopotentiation of enzalutamide over human prostate cancer cells as assessed by real-time cell monitoring
ConclusionsThese results provide evidence that the enzalutamide/radiotherapy combination could maximize therapeutic responses in patients with enzalutamide-sensitive prostate cancer. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 23, 2019 Category: Cancer & Oncology Source Type: research

A review of automatic lung tumour segmentation in the era of 4DCT
ConclusionAuto-contouring is reliable and efficient, producing accurate contours with better consistency compared to manual contours. However, manual inputs would still be required both before and after auto-propagation. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 23, 2019 Category: Cancer & Oncology Source Type: research

The case for radiotherapy in a Value based environment
ConclusionsIn the United States, stabilizing costs in the face of increasing work, better outcomes, and decreased toxicity contributes to increasing RT value over the past 10 years. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 21, 2019 Category: Cancer & Oncology Source Type: research

Dosimetric impact of statistical uncertainty on Monte Carlo dose calculation algorithm in volumetric modulated arc therapy using Monaco TPS for three different clinical cases
ConclusionFor VMAT plans, SU can be accepted from 1% to 3% per plan with reduced calculation time without compromising plan quality and deliverability by accepting variations in point dose within the target. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 19, 2019 Category: Cancer & Oncology Source Type: research

Gene delivery methods and genome editing of human pluripotent stem cells
Publication date: March–April 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 2Author(s): Patrycja Czerwińska, Sylwia Mazurek, Iga Kołodziejczak, Maciej WiznerowiczAbstractInduced pluripotent stem cells derived from normal somatic cells could be utilized to study tumorigenesis through overexpression of specific oncogenes, downregulation of tumor suppressors and dysregulation of other factors thought to promote tumorigenesis. Therefore, effective approaches that provide direct modifications of induced pluripotent stem cell genome are extremely needed. Emerging strategies are expected to provid...
Source: Reports of Practical Oncology and Radiotherapy - February 19, 2019 Category: Cancer & Oncology Source Type: research

Variables altering the impact of respiratory gated CT simulation on planning target volume in radiotherapy for lung cancer
ConclusionThe use of 4D-simulation reduces the PTV for the primary tumor in lung cancer cases. Further studies with larger samples are required to confirm the benefit of 4D-simulation in decreasing PTV in lung cancer. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 17, 2019 Category: Cancer & Oncology Source Type: research

Effectiveness of different accelerated partial breast irradiation techniques for the treatment of breast cancer patients: Systematic review using indirect comparisons of randomized clinical trials
ConclusionsBased on indirect comparisons, no differences in clinical outcomes were observed among diverse APBI techniques in published clinical trials that formally compared WBI to APBI. However wide confidence intervals and high risk of inconsistency precluded a sound conclusion. Further head-to-head clinical trials comparing different APBI techniques are required to confirm our findings. Studies comparing different techniques using individual participant data and/or real-life data from population-based studies/registries could also provide more robust results. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 16, 2019 Category: Cancer & Oncology Source Type: research

In vivo dosimetry of the rectum in image-guided adaptive interstitial-intracavitary brachytherapy of cervix cancer – A feasibility study
ConclusionsUnder treatment conditions, the semiconductor diode does not provide reliable measured data. The probe pushes the rectal wall closer to the high dose areas and underestimates the dose of it. Semiconductor probe is not recommended for in vivo dosimetry of the rectum in image-guided brachytherapy of cervical cancer. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 15, 2019 Category: Cancer & Oncology Source Type: research

Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines
Publication date: March–April 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 2Author(s): Jakub Dalibor RybkaAbstractMelanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, whic...
Source: Reports of Practical Oncology and Radiotherapy - February 7, 2019 Category: Cancer & Oncology Source Type: research

Corrigendum to “Why should radiation oncology do translational research?” [Rep Pract Oncol Radiother 2019;24(1):60–64]
Publication date: March–April 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 2Author(s): Rut Cañas, Isabel Linares, Ferran Guedea, Miguel Ángel Berenguer Francés (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - January 25, 2019 Category: Cancer & Oncology Source Type: research

Local control rates in stereotactic body radiotherapy (SBRT) of lung metastases associated with the biologically effective dose
ConclusionsLung metastases treated with SBRT, with delivered BED99% > 85 Gy and BED50% > 100 Gy, present better local control rates than those treated with lower BED values (p = 0.001). (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - January 23, 2019 Category: Cancer & Oncology Source Type: research

Improved error detection using a divided treatment plan in volume modulated arc therapy
ConclusionThe error discrimination ability was improved by dividing and verifying the portal imaging. (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - January 23, 2019 Category: Cancer & Oncology Source Type: research

Editorial board
Publication date: January–February 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 1Author(s): (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - January 20, 2019 Category: Cancer & Oncology Source Type: research