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Development of Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction
Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). While PH-HFpEF may affect more than a million patients in the United States alone, it has been difficult to study its epidemiology and response to treatment due to difficulty in properly defining the illness. While chronic remodeling of the pulmonary vasculature is related to chronic passive congestion of the pulmonary circulation from the pulmonary veins, there are likely other contributors to the development of PH-HFpEF. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - June 23, 2016 Category: Cardiology Authors: Grant Farr, Keyur Shah, Roshi Markley, Antonio Abbate, Fadi N. Salloum, Dan Grinnan Source Type: research

Physiological Techniques and Pulmonary Hypertension – Left Heart Disease
Group 2 Pulmonary hypertension (PH) is associated with left heart disease (LHD;Group 2 PH) and is the most common form of PH. Group 2 PH represents an important subgroup of patients with LHD where the development of PH leads to a significant increase in morbidity and mortality. Early diagnosis may provide an opportunity to intervene and significantly delay progression. In addition to clinical suspicion, several approaches including hemodynamic assessment, exercise testing, and imaging techniques play an important role in better disease characterization and management. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Manyoo Agarwal, Aaron B. Waxman Source Type: research

Patient-Based Clinical Innovations by Practicing Physicians —A Commentary
An evaluation of the major advances in clinical medicine before the 19th century reveals the role that individual doctors played in optimizing clinical therapeutics despite the lack of a scientific underpinning. A few specific examples stand out including Dr. James Lind who demonstrated in 1753 that one could treat and prevent scurvy with citrus fruit; Dr. Edward Jenner who used material from cowpox lesions in 1796 to effectively prevent smallpox; Dr. Semmelweis who introduced hand and instrument washing in 1824 to prevent surgical infections prior to the understanding of bacteria and infectious disease; and in the 1820s, ...
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Arthur J. Moss, Katherine M. Lowengrub Tags: Editorial Source Type: research

Physiological Techniques and Pulmonary Hypertension – Left Heart Disease
Group 2 Pulmonary hypertension (PH) is associated with left heart disease (LHD;Group 2 PH) and is the most common form of PH. Group 2 PH represents an important subgroup of patients with LHD where the development of PH leads to a significant increase in morbidity and mortality. Early diagnosis may provide an opportunity to intervene and significantly delay progression. In addition to clinical suspicion, several approaches including hemodynamic assessment, exercise testing, and imaging techniques play an important role in better disease characterization and management. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Manyoo Agarwal, Aaron B. Waxman Source Type: research

Patient-Based Clinical Innovations by Practicing Physicians—A Commentary
An evaluation of the major advances in clinical medicine before the 19th century reveals the role that individual doctors played in optimizing clinical therapeutics despite the lack of a scientific underpinning. A few specific examples stand out including Dr. James Lind who demonstrated in 1753 that one could treat and prevent scurvy with citrus fruit; Dr. Edward Jenner who used material from cowpox lesions in 1796 to effectively prevent smallpox; Dr. Semmelweis who introduced hand and instrument washing in 1824 to prevent surgical infections prior to the understanding of bacteria and infectious disease; and in the 1820s, ...
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Arthur J. Moss, Katherine M. Lowengrub Tags: Editorial Source Type: research

Physiological Techniques and Pulmonary Hypertension- Left Heart Disease
Group 2 Pulmonary hypertension (PH) is associated with left heart disease ( LHD;Group 2 PH) and is the most common form of PH. Group 2 PH represents an important subgroup of patients with LHD where the development of PH leads to a significant increase in morbidity and mortality. Early diagnosis may provide an opportunity to intervene and significantly delay progression. In addition to clinical suspicion, several approaches including hemodynamic assessment, exercise testing, and imaging techniques play an important role in better disease characterization and management. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Manyoo Agarwal, Aaron B. Waxman Source Type: research

Patient-Based Clinical Innovations by Practicing Physicians – A Commentary
An evaluation of the major advances in clinical medicine before the 19th century reveals the role that individual doctors played in optimizing clinical therapeutics despite the lack of a scientific underpinning. A few specific examples stand out including Dr. James Lind who demonstrated in 1753 that one could treat and prevent scurvy with citrus fruit; Dr. Edward Jenner who used material from cowpox lesions in 1796 to effectively prevent smallpox; Dr. Semmelweis who introduced hand and instrument washing in 1824 to prevent surgical infections prior to the understanding of bacteria and infectious disease; and in the 1820s, ...
Source: Progress in Cardiovascular Diseases - May 17, 2016 Category: Cardiology Authors: Arthur J. Moss, Katherine M. Lowengrub Source Type: research

Lung Capillary Stress Failure and Arteriolar Remodelling in Pulmonary Hypertension Associated with Left Heart Disease (Group 2 PH)
Left heart diseases (LHD) represent the most prevalent cause of pulmonary hypertension (PH), yet there are still no approved therapies that selectively target the pulmonary circulation in LHD. The increase in pulmonary capillary pressure due to LHD is a triggering event leading to physical and biological alterations of the pulmonary circulation. Acutely, mechanosensitive endothelial dysfunction and increased capillary permeability combined with reduced fluid resorption lead to the development of interstitial and alveolar oedema. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 15, 2016 Category: Cardiology Authors: Nour R. Dayeh, Jonathan Ledoux, Jocelyn Dupuis Source Type: research

The Diagnostic Challenge of Group 2 Pulmonary Hypertension
Pulmonary hypertension (PH) secondary to left heart diseases associated with an increased pulmonary venous pressure is the second of a total of five groups recognized in the classification of PH. Group 2 PH is the commonest form of PH, and is associated with high morbidity and mortality. The diagnosis of group 2 PH relies on a clinical probability assessment in which echocardiography plays a major role, eventually followed by the invasive measurements of a mean pulmonary artery pressure (mPAP) ≥25mmHg and a wedged PAP (PAWP) > 15mmHg. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 15, 2016 Category: Cardiology Authors: Robert Naeije, Michele D ’Alto Source Type: research

Lung Capillary Stress Failure and Arteriolar Remodelling in Pulmonary Hypertension Associated with Left Heart Disease (group 2 PH)
Left heart diseases (LHD) represent the most prevalent cause of pulmonary hypertension (PH), yet there are still no approved therapies that selectively target the pulmonary circulation in LHD. The increase in pulmonary capillary pressure due to LHD is a triggering event leading to physical and biological alterations of the pulmonary circulation. Acutely, mechanosensitive endothelial dysfunction and increased capillary permeability combined with reduced fluid resorption lead to the development of interstitial and alveolar oedema. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 15, 2016 Category: Cardiology Authors: Nour R. Dayeh, Jonathan Ledoux, Jocelyn Dupuis Source Type: research

The diagnostic challenge of group 2 pulmonary hypertension
Pulmonary hypertension (PH) secondary to left heart diseases associated with an increased pulmonary venous pressure is the second of a total of five groups recognized in the classification of PH. Group 2 PH is the commonest form of PH, and is associated with high morbidity and mortality. The diagnosis of group 2 PH relies on a clinical probability assessment in which echocardiography plays a major role, eventually followed by the invasive measurements of a mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and a wedged PAP (PAWP) > 15 mmHg. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - May 15, 2016 Category: Cardiology Authors: Robert Naeije, Michele D’Alto Source Type: research

Let ’s Face It: Consumer-Focused Technology Is the Future of Cardiovascular Disease Prevention and Treatment
Cardiovascular disease (CVD) is the leading cause of disability and death in the United States (US), constituting 17% of overall national healthcare expenditures.1 With forecasts of a steady rise in the incidence and prevalence of CVD over the next 10 –20 years, the annual costs are projected to experience a threefold increase to $818 billion by 2030.1 Similar trends can also be observed in other regions of the globe.2,3 Unfortunately, complications associated with preventable risk factors (i.e., weight mismanagement, unhealthy dietary choices, sedentary behaviors, tobacco use, and alcohol abuse) continue to constitute ...
Source: Progress in Cardiovascular Diseases - April 30, 2016 Category: Cardiology Authors: Nina C. Franklin, Michael Pratt Tags: Editorial Source Type: research

Technology and Public Health: New Tools and Perspectives
In this issue we see that technology is increasingly impacting both clinical medicine and public health. This is manifest in diverse countries and populations, in research and practice, and in the diagnosis, treatment, surveillance, and prevention of chronic disease. A more disruptive aspect of technology is the wide uptake of smart phones, applications, and fitness tracking devices that now put tools in the hands of the public with capabilities previously found only in laboratories and clinics. (Source: Progress in Cardiovascular Diseases)
Source: Progress in Cardiovascular Diseases - April 30, 2016 Category: Cardiology Authors: Michael Pratt, Nina C. Franklin Tags: Commentary Source Type: research