CXCL ‐10 and Interleukin‐6 are reliable serum markers for vitiligo activity: A multicenter cross‐sectional study
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 330-336, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 241-252, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
PDCD1 gene polymorphisms as regulators of T ‐lymphocyte activity in cutaneous melanoma risk and prognosis
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 308-317, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 330-336, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 241-252, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 308-317, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Source Type: research
PDCD1 Gene Polymorphisms as Regulators of T ‐Lymphocyte Activity in Cutaneous Melanoma Risk and Prognosis
This study aimed to evaluate whether PD1.1 (c.‐606G>A), PD1 (c.627+252C>T), PD1.5 (c.804C>T) and PD1.9 (c.644C>T) single nucleotide polymorphisms of PDCD1 gene influence the risk, clinicopathological aspects and survival of cutaneous melanoma (CM). Individuals with phototype I or II and PD1 CC genotype were under 5.89‐fold increased risk of developing CM. PD1.5 TT genotype increased PDCD1 expression (2.49 vs. 1.28 arbitrary units, P= 0.03) and PD1.5 CT or TT genotype and allele T increased PD1 expression in TCD4+ lymphocytes (16.6 vs. 12.5%, P= 0.01; 17.0 vs. 13.1%, P= 0.006). At 60 months of follow‐up, s...
Source: Pigment Cell Research - November 1, 2017 Category: Cytology Authors: Gabriela Vilas B ôas Gomez, José Augusto Rinck‐Junior, Cristiane de Oliveira, Dennis Henrique Leandro da Silva, Ronei Luciano Mamoni, Gustavo Jacob Lourenço, Aparecida Machado de Moraes, Carmen Silvia Passos Lima Tags: Original Article Source Type: research
In vivo knockdown of antisense non ‐coding mitochondrial RNAs by a lentiviral‐encoded shRNA inhibits melanoma tumor growth and lung colonization
In this study, we knocked down the ASncmtRNAs in melanoma cell lines with a lentiviral‐encoded shRNA approach. Transduction with lentiviral constructs targeted to the ASncmtRNAs induced apoptosis in murine B16F10 and human A375 melanoma cells in vitro and significantly retarded B16F10 primary tumor growth in vivo. Moreover, the treatment drastically reduced the number of lung metastatic foci in a tail vein injection assay, compared to controls. These results provide additional proof of concept to the knockdown of ncmtRNAs for cancer therapy and validate lentiviral–shRNA vectors for gene therapy. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 21, 2017 Category: Cytology Authors: Manuel Varas ‐Godoy, Alvaro Lladser, Nicole Farfan, Claudio Villota, Jaime Villegas, Julio C. Tapia, Luis O. Burzio, Veronica A. Burzio, Pablo D. T. Valenzuela Tags: ORIGINAL ARTICLE Source Type: research
The avidity of tumor ‐specific T cells amplified by a plasmacytoid dendritic cell‐based assay can predict the clinical evolution of melanoma patients
Summary
The advent of immune checkpoint blockers and targeted therapies has changed the outcome of melanoma. However, many patients experience relapses, emphasizing the need for predictive and prognostic biomarkers. We developed a strategy based on plasmacytoid dendritic cells (pDCs) loaded with melanoma tumor antigens that allows eliciting highly efficient antitumor T‐cell responses. We used it to investigate antitumor T‐cell functionality in peripheral blood mononuclear cells and tumor‐infiltrating lymphocytes from melanoma patients. The pDCs elicited tumor‐specific T cells in different proportions and displaying...
Source: Pigment Cell Research - October 21, 2017 Category: Cytology Authors: Julie Charles, Laurence Chaperot, Bruno Revol, Marine Baudin, Stephane Mouret, Agnes Hamon, Marie ‐Therese Leccia, Joel Plumas, Caroline Aspord Tags: ORIGINAL ARTICLE Source Type: research
Characterization of melanosomes and melanin in Japanese patients with Hermansky –Pudlak syndrome types 1, 4, 6, and 9
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 267-276, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 20, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 267-276, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 20, 2017 Category: Cytology Source Type: research
Clinico ‐molecular analysis of eleven patients with Hermansky–Pudlak type 5 syndrome, a mild form of HPS
We report 11 new pathogenic variants. The 11 patients present with ocular features that are typical for albinism, with mild hypopigmentation, and with no other major complication, apart from a tendency to bleed. HPS‐5 therefore appears as a mild form of HPS, which is often clinically undistinguishable from mild oculocutaneous or ocular forms of albinism. Molecular analysis is therefore required to establish the diagnosis of this mild HPS form, which has consequences in terms of prognosis and of clinical management of the patients. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 20, 2017 Category: Cytology Authors: Vincent Michaud, Eulalie Lasseaux, Claudio Plaisant, Alain Verloes, Yaumara Perdomo ‐Trujillo, Christian Hamel, Nursel H. Elcioglu, Bart Leroy, Josseline Kaplan, Pierre‐Simon Jouk, Didier Lacombe, Patricia Fergelot, Fanny Morice‐Picard, Benoit Arvei Tags: SHORT COMMUNICATION Source Type: research
Melanoma sponge on pigmentation gene to reduce tumour ‐suppressive microRNAs
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 19, 2017 Category: Cytology Authors: Peter Dietrich, Anja Katrin Bosserhoff Tags: News & Views Source Type: research
Sticky fingers at work: Palmitoylation ‐dependent MC1R activation
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 238-240, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 17, 2017 Category: Cytology Source Type: research
Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 277-286, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - October 17, 2017 Category: Cytology Source Type: research
