---
Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 21, 2017 Category: Cytology Source Type: research
Melanoma in patients with GATA2 deficiency
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 337-340, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 20, 2017 Category: Cytology Source Type: research
---
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 337-340, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 20, 2017 Category: Cytology Source Type: research
Association of PD ‐L1 expression with treatment outcomes in patients with BRAF mutation–positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 20, 2017 Category: Cytology Authors: Matthew J. Wongchenko, Antoni Ribas, Brigitte Dr éno, Paolo A. Ascierto, Grant A. McArthur, Jorge D. Gallo, Isabelle A. Rooney, Jessie Hsu, Hartmut Koeppen, Yibing Yan, James Larkin Tags: Original Article Source Type: research
Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development
Summary
Resistance to targeted therapy in cancer is often coupled with the acquisition of a pro‐invasive phenotype by tumors cells and a highly permissive tumor microenvironment promoting drug resistance. Transcription factors are frequently shown as major points of convergence of multiple dysregulated receptors and signaling pathways in cancer. Several transcription factors are now incriminated as drivers of both drug resistance and invasiveness. We focused this review on critical transcription factors playing a causal role in both the resistance to BRAF V600E‐targeted therapy and the pro‐invasive behavior of melano...
Source: Pigment Cell Research - November 15, 2017 Category: Cytology Authors: Karine A. Cohen ‐Solal, Howard L. Kaufman, Ahmed Lasfar Tags: REVIEW Source Type: research
Naevus lightening in melanoma patients under BRAF/MEK inhibitor combination therapy versus checkpoint immunotherapy: A histological and immunohistochemistry analysis
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 341-344, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 13, 2017 Category: Cytology Source Type: research
---
Pigment Cell&Melanoma Research,Volume 31, Issue 2, Page 341-344, March 2018. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 13, 2017 Category: Cytology Source Type: research
Melanin quantification by in vitro and in vivo analysis of near ‐infrared fluorescence
Summary
Objective measurements of melanin can provide important information for differentiating melanoma from benign pigmented lesions and in assessing pigmentary diseases. Herein, we evaluate near‐infrared (NIR) fluorescence as a possible tool to quantify melanin. Various concentrations of in vitro Sepia melanin in tissue phantoms were measured with NIR fluorescence and diffuse reflectance spectroscopy. Similar optic measurements were conducted in vivo on 161 normal human skin sites. Diffuse reflectance spectroscopy was used to quantify the melanin content via Stamatas–Kollias algorithm. At physiologic concentrations,...
Source: Pigment Cell Research - November 5, 2017 Category: Cytology Authors: Sunil Kalia, Jianhua Zhao, Haishan Zeng, David McLean, Nikiforos Kollias, Harvey Lui Tags: ORIGINAL ARTICLE Source Type: research
Melanoma sponge on pigmentation gene to reduce tumour ‐suppressive microRNAs
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Source Type: research
---
Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Source Type: research
Dual MEK/AKT inhibition with trametinib and GSK2141795 does not yield clinical benefit in metastatic NRAS ‐mutant and wild‐type melanoma
Summary
Aberrant MAPK and PI3K pathway signaling may drive the malignant phenotype in NRAS‐mutant and BRAFWT NRASWT metastatic melanoma. To target these pathways, NRAS‐mutant and BRAFWT NRASWT patients received oral trametinib at 1.5 mg daily and GSK2141795 at 50 mg daily in a two‐cohort Simon two‐stage design. Participants had adequate end‐organ function and no more than two prior treatment regimens. Imaging assessments were performed at 8‐week intervals. A total of 10 NRAS‐mutant and 10 BRAFWT NRASWT patients were enrolled. No objective responses were noted in either cohort. The median PFS and OS were 2.3...
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Authors: Alain P. Algazi, Rosaura Esteve ‐Puig, Adi Nosrati, Brian Hinds, Adele Hobbs‐Muthukumar, Prachi Nandoskar, Susana Ortiz‐Urda, Paul B. Chapman, Adil Daud Tags: SHORT COMMUNICATION Source Type: research
List of reviewers for Volume 30
(Source: Pigment Cell Research)
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Tags: LIST OF REVIEWERS Source Type: research
Futures
(Source: Pigment Cell Research)
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Authors: Heinz Arnheiter Tags: EDITORIAL Source Type: research
Issue Information
(Source: Pigment Cell Research)
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Tags: ISSUE INFORMATION Source Type: research
Characterization of melanosomes and melanin in Japanese patients with Hermansky –Pudlak syndrome types 1, 4, 6, and 9
In this study, we identified one patient each with HPS4, HPS6, and HPS9 by whole‐exome sequencing. Next, we analyzed hair samples from the three patients and representative patients with HPS1 and controls using electron microscopy and chemical methods. All HPS patients had fewer, smaller, and more immature melanosomes than healthy controls. Further, all patients showed reduced total melanin content and increased levels of benzothiazine‐type pheomelanin. The results of this study demonstrate the impact of the dysfunctions of BLOCs on the maturation of melanosomes and melanin levels and composition through analysis of th...
Source: Pigment Cell Research - November 2, 2017 Category: Cytology Authors: Ken Okamura, Yuko Abe, Yuta Araki, Kazumasa Wakamatsu, Mariko Seishima, Takafumi Umetsu, Atsushi Kato, Masakazu Kawaguchi, Masahiro Hayashi, Yutaka Hozumi, Tamio Suzuki Tags: ORIGINAL ARTICLE Source Type: research
