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Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 10, 2017 Category: Cytology Source Type: research
Association of programmed death ligand ‐1 (PD‐L1) expression with treatment outcomes in patients with BRAF mutation‐positive melanoma treated with vemurafenib or cobimetinib combined with vemurafenib
Summary
The prognostic significance of programmed death ligand‐1 (PD‐L1) on treatment outcomes in patients receiving BRAF with or without MEK inhibitors is not well understood. This retrospective exploratory analysis evaluated the association of tumour PD‐L1 expression with progression‐free survival (PFS) and overall survival (OS) among 210 patients in the coBRIM trial treated with cobimetinib plus vemurafenib or placebo plus vemurafenib. In the vemurafenib cohort, there was a trend of increased PFS and OS in those with PD‐L1+ melanoma, with hazard ratios (HRs; PD‐L1+ vs. PD‐L1−) of 0.70 (95% CI, 0.46–1.0...
Source: Pigment Cell Research - December 10, 2017 Category: Cytology Authors: Matthew J. Wongchenko, Antoni Ribas, Brigitte Dr éno, Paolo A. Ascierto, Grant A. McArthur, Jorge D. Gallo, Isabelle A. Rooney, Jessie Hsu, Hartmut Koeppen, Yibing Yan, James Larkin Tags: ORIGINAL ARTICLE Source Type: research
Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death ‐associated protein like‐1 DAPL1 by alternative MITF splice forms
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 9, 2017 Category: Cytology Source Type: research
Acid hydrolysis reveals a low but constant level of pheomelanin in human black to brown hair
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 9, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 9, 2017 Category: Cytology Source Type: research
Metastasis ‐specific patterns of response and progression with anti‐PD‐1 treatment in metastatic melanoma
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 7, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 7, 2017 Category: Cytology Source Type: research
Insect cuticular melanins are distinctly different from those of mammalian epidermal melanins
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 4, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - December 4, 2017 Category: Cytology Source Type: research
D ‐tyrosine negatively regulates melanin synthesis by competitively inhibiting tyrosinase activity
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 27, 2017 Category: Cytology Source Type: research
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Pigment Cell&Melanoma Research, Ahead of Print. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 27, 2017 Category: Cytology Source Type: research
Acid hydrolysis reveals a low but constant level of pheomelanin in human black to brown hair
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 24, 2017 Category: Cytology Authors: Shosuke Ito, Shiho Miyake, Shoji Maruyama, Itaru Suzuki, St éphane Commo, Yukiko Nakanishi, Kazumasa Wakamatsu Tags: Original Article Source Type: research
Metastasis ‐specific patterns of response and progression with anti‐PD‐1 treatment in metastatic melanoma
This study evaluated patterns of response as discerned by comprehensive metastasis‐specific analysis in metastatic melanoma patients receiving anti‐PD‐1 antibodies. Bi‐dimensional measurements of every metastasis in patients enrolled in the KEYNOTE‐001 trial at a single institution were obtained at baseline and throughout treatment. Twenty‐seven evaluable patients had 399 baseline metastases measurable on CT imaging. Complete response (CR) which occurred in 52.6% of metastases was smaller (mean 223mm2 vs. 760mm2, p < 0.01) and occurred more frequently in the lungs (65% vs 39.4%, p < 0.01). Response was he...
Source: Pigment Cell Research - November 24, 2017 Category: Cytology Authors: Jenny HJ Lee, Megan Lyle, Alexander M Menzies, Matthew MK Chan, Serigne Lo, Arthur Clements, Matteo S Carlino, Richard F Kefford, Georgina V Long Tags: Original Article Source Type: research
Running INTERFERONce on immunotherapy
Pigment Cell&Melanoma Research, EarlyView. (Source: Pigment Cell Research)
Source: Pigment Cell Research - November 21, 2017 Category: Cytology Source Type: research
