Targeting Cholesterol Transport in Circulating Melanoma Cells to Inhibit Metastasis
This study investigates whether targeting cholesterol transport in melanoma CTCs can retard metastasis development. Nanolipolee‐007, the liposomal form of leelamine, reduced melanoma metastasis in both a novel in vitro flow system mimicking the circulating system and in experimental as well as spontaneous animal metastasis models, irrespective of the BRAF mutational status of the CTCs. Leelamine led to cholesterol trapping in lysosomes, which subsequently shut down receptor mediated endocytosis, endosome trafficking and inhibited the major oncogenic signaling cascades important for survival such as the AKT pathway. Since...
Source: Pigment Cell Research - July 1, 2017 Category: Cytology Authors: Yu ‐Chi Chen, Raghavendra Gowda, Raymond K. Newswanger, Patrick Leibich, Barry Fell, Gerson Rosenberg, Gavin P Robertson Tags: Original Article Source Type: research
Getting a tan without getting SIK
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - July 1, 2017 Category: Cytology Authors: John D'Orazio Tags: News & Views Source Type: research
Filling the gaps in the genomic catalogue of melanoma subtypes
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 28, 2017 Category: Cytology Authors: A. Hunter Shain, Boris C. Bastian Tags: News & Views Source Type: research
Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 26, 2017 Category: Cytology Authors: Hannah E. Seberg, Eric Van Otterloo, Robert A. Cornell Tags: Review Source Type: research
Melanoma ‐associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 24, 2017 Category: Cytology Authors: Ana Neto, Craig J. Ceol Tags: Short Communication Source Type: research
Restoration of Cutaneous Pigmentation by Transplantation to Mice of Isogeneic Human Melanocytes in Dermal ‐epidermal Engineered Skin Substitutes
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 23, 2017 Category: Cytology Authors: Steven T. Boyce, Christopher M. Lloyd, Mark C. Kleiner, Viki B. Swope, Zalfa Abdel ‐Malek, Dorothy M. Supp Tags: Original Article Source Type: research
A major responder to ipilimumab and nivolumab in metastatic uveal melanoma with concomitant autoimmunity
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 22, 2017 Category: Cytology Authors: Pui Ying Chan, Peter Hall, Gordon Hay, Victoria M L Cohen, Peter W Szlosarek Tags: Short Communication Source Type: research
Clinico ‐molecular analysis of eleven patients with Hermansky‐Pudlak type 5 syndrome, a mild form of HPS
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 22, 2017 Category: Cytology Authors: Vincent Michaud, Eulalie Lasseaux, Claudio Plaisant, Alain Verloes, Yaumara Perdomo ‐Trujillo, Christian Hamel, Nursel H. Elcioglu, Bart Leroy, Josseline Kaplan, Pierre‐Simon Jouk, Didier Lacombe, Patricia Fergelot, Fanny Morice‐Picard, Benoit Arvei Tags: Short Communication Source Type: research
Graphical displays
(Source: Pigment Cell Research)
Source: Pigment Cell Research - June 21, 2017 Category: Cytology Authors: Heinz Arnheiter Tags: EDITORIAL Source Type: research
Issue Information
(Source: Pigment Cell Research)
Source: Pigment Cell Research - June 21, 2017 Category: Cytology Tags: ISSUE INFORMATION Source Type: research
Reply to “Clinical and therapeutic implications of BRAF mutation heterogeneity in metastatic melanoma” by Mesbah Ardakani et al
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 19, 2017 Category: Cytology Authors: Am élie Boespflug, Elisa Funck‐Brentano, Zofia Hélias‐Rodzewicz, Delphine Maucort‐Boulch, Alain Beauchet, Pierre‐Paul Bringuier, Charles Dumontet, Jean‐François Emile, Philippe Saiag, Stéphane Dalle Tags: Letter to the Editor Source Type: research
When metastasis ‘Spns’ out of control: Coverage of ‘Genome‐wide in vivo screen identifies novel host regulators of metastatic colonization’
(Source: Pigment Cell Research)
Source: Pigment Cell Research - June 13, 2017 Category: Cytology Authors: Marie R. Webster, Curtis H. Kugel, Ashani T. Weeraratna Tags: NEWS AND VIEWS Source Type: research
Meeting report: Vitiligo Global Issues Consensus Conference Workshop “Outcome measurement instruments” and Vitiligo International Symposium, Rome, Nov 30–Dec 3rd
(Source: Pigment Cell Research)
Source: Pigment Cell Research - June 13, 2017 Category: Cytology Authors: Nanja Geel, Katia Boniface, Julien Seneschal, Cl ément Jacquemin, Reinhart Speeckaert, Albert Wolkerstorfer, Marcel Bekkenk, Janny E. Lommerts, Iltefat Hamzavi, Amit Pandya, Viktoria Eleftheriadou, Khaled Ezzedine, Diana Giannarelli, Maria Gnarra, Isabel Tags: MEETING REPORT Source Type: research
No association between prediagnosis exercise and survival in patients with high ‐risk primary melanoma: A population‐based study
(Source: Pigment Cell Research)
Source: Pigment Cell Research - June 8, 2017 Category: Cytology Authors: Emily Schwitzer, Irene Orlow, Emily C. Zabor, Colin B. Begg, Marianne Berwick, Nancy E. Thomas, Peter A. Kanetsky, Lee W. Jones, Tags: LETTER TO THE EDITOR Source Type: research
FBXW7 inactivation in a BrafV600E ‐driven mouse model leads to melanoma development
This article is protected by copyright. All rights reserved. (Source: Pigment Cell Research)
Source: Pigment Cell Research - June 5, 2017 Category: Cytology Authors: Iraz T. Aydin, Franco Abbate, Geena Susan Rajan, Brateil Badal, Iannis Aifantis, Garrett Desman, Julide Tok Celebi Tags: Letter to the Editor Source Type: research
