PDCD1 Gene Polymorphisms as Regulators of T ‐Lymphocyte Activity in Cutaneous Melanoma Risk and Prognosis
This study aimed to evaluate whether PD1.1 (c.‐606G>A), PD1 (c.627+252C>T), PD1.5 (c.804C>T) and PD1.9 (c.644C>T) single nucleotide polymorphisms of PDCD1 gene influence the risk, clinicopathological aspects and survival of cutaneous melanoma (CM). Individuals with phototype I or II and PD1 CC genotype were under 5.89‐fold increased risk of developing CM. PD1.5 TT genotype increased PDCD1 expression (2.49 vs. 1.28 arbitrary units, P= 0.03) and PD1.5 CT or TT genotype and allele T increased PD1 expression in TCD4+ lymphocytes (16.6 vs. 12.5%, P= 0.01; 17.0 vs. 13.1%, P= 0.006). At 60 months of follow‐up, short recurrence‐free survival was seen in patients with PD1.1 AA genotype (33.3 vs. 71.8%, P= 0.03). Patients with PD1.1 AA and PD1.5 CC genotype had 4.21 and 2.62 more chances of presenting relapse and evolving death by disease in Cox analyses, respectively. Our data provides preliminary evidence that abnormalities in regulation of T‐lymphocyte alter CM risk, clinical aspects and prognosis.
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Source: Pigment Cell Research - Category: Cytology Authors: Gabriela Vilas B ôas Gomez, José Augusto Rinck‐Junior, Cristiane de Oliveira, Dennis Henrique Leandro da Silva, Ronei Luciano Mamoni, Gustavo Jacob Lourenço, Aparecida Machado de Moraes, Carmen Silvia Passos Lima Tags: Original Article Source Type: research