Nitric oxide as an active substance in the enteric neurons of the porcine digestive tract in physiological conditions and under intoxication with bisphenol A (BPA)
Publication date: Available online 4 August 2018Source: Nitric OxideAuthor(s): Kamila Szymanska, Jaroslaw Calka, Slawomir GonkowskiAbstractBisphenol A (BPA) is an organic substance, which is commonly used in the production of plastic. It is known that BPA has the negative impact on the living organism, affecting among others the reproductive organs, nervous, endocrine and immune systems. Nevertheless the knowledge about the influence of BPA on the enteric nervous system (ENS) is extremely scanty. On the other hand, nitric oxide is considered to be one of the most important neuronal factors in the ENS. The aim of the study ...
Source: Nitric Oxide - August 6, 2018 Category: Chemistry Source Type: research
A novel role of sONE/NOS3/NO signaling cascade in mediating hydrogen sulphide bilateral effects on triple negative breast cancer progression
In conclusion, this study provides an insight about the role of exogenous H2S in TNBC cell lines highlighting a novel crosstalk between H2S and NO orchestrated by sONE/NOS3 axis. (Source: Nitric Oxide)
Source: Nitric Oxide - August 4, 2018 Category: Chemistry Source Type: research
Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ
Publication date: Available online 29 July 2018Source: Nitric OxideAuthor(s): Tomoya Kawakami, Atsushi Koike, Fumio AmanoAbstractMacrophages are known to play pivotal roles in host-defense through inflammation via both innate and acquired immune systems, and so on. In an earlier paper, we showed the influence of the type of culture medium, Ham's F-12 or DMEM, on activated macrophage phenotypes induced by LPS and IFNγ. The production of nitric oxide (NO), pro-inflammatory cytokines such as TNFα and IL-1β, as well as the induction of superoxide-generating activity of J774.1/JA-4 cells was different depending on the type...
Source: Nitric Oxide - July 29, 2018 Category: Chemistry Source Type: research
Detection of dinitrosyl iron complexes by ozone-based chemiluminescence
Publication date: Available online 27 July 2018Source: Nitric OxideAuthor(s): George T. Mukosera, Taiming Liu, Abu Shufian Ishtiaq Ahmed, Qian Li, Matilda H.-C. Sheng, Trent E. Tipple, David J. Baylink, Gordon G. Power, Arlin B. BloodAbstractDinitrosyl iron complexes (DNICs) are important intermediates in the metabolism of nitric oxide (NO). They have been considered to be NO storage adducts able to release NO, scavengers of excess NO during inflammatory hypotensive shock, and mediators of apoptosis in cancer cells, among many other functions. Currently, all studies of DNICs in biological matrices use electron paramagnetic...
Source: Nitric Oxide - July 27, 2018 Category: Chemistry Source Type: research
Mineralocorticoid receptor blockade improves arginine transport and nitric oxide generation through modulation of cationic amino acid transporter-1 in endothelial cells
In conclusion spironolactone and eplerenone augment arginine transport and NO generation through modulation of CAT-1 in endothelial cells. Both MCR antagonists activate CAT-1 by inducing its glycosylation while only spironolactone inhibits PKCα. (Source: Nitric Oxide)
Source: Nitric Oxide - July 27, 2018 Category: Chemistry Source Type: research
