Variability in nitrate-reducing oral bacteria and nitric oxide metabolites in biological fluids following dietary nitrate administration: An assessment of the critical difference
Publication date: Available online 5 December 2018Source: Nitric OxideAuthor(s): Luke Liddle, Mia C. Burleigh, Chris Monaghan, David J. Muggeridge, Nicholas Sculthorpe, Charles R. Pedlar, John Butcher, Fiona L. Henriquez, Chris EastonAbstractThere is conflicting evidence on whether dietary nitrate supplementation can improve exercise performance. This may arise from the complex nature of nitric oxide (NO) metabolism which causes substantial inter-individual variability, within-person biological variation (CVB), and analytical imprecision (CVA) in experimental endpoints. However, no study has quantified the CVA and CVB of N...
Source: Nitric Oxide - December 6, 2018 Category: Chemistry Source Type: research
Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease
Publication date: Available online 5 December 2018Source: Nitric OxideAuthor(s): Fernando E. Padovan-Neto, Lauren Jurkowski, Conor Murray, Grace E. Stutzmann, Mei Kwan, Afshin Ghavami, Vahri Beaumont, Larry C. Park, Anthony R. WestAbstractIn Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in corticostriatal circuits in HD, however, the impact of age and sex on nitrergic transmission is not well characterized. Thus, we utilized NADPH-diaphorase ...
Source: Nitric Oxide - December 6, 2018 Category: Chemistry Source Type: research
Neuronal nitric oxide synthase (nNOS) splice variant function: Insights into nitric oxide signaling from skeletal muscle
Publication date: Available online 29 November 2018Source: Nitric OxideAuthor(s): Jordan E. Balke, Ling Zhang, Justin M. PercivalAbstractDefects in neuronal nitric oxide synthase (nNOS) splice variant localization and signaling in skeletal muscle are a firmly established pathogenic characteristic of many neuromuscular diseases, including Duchenne and Becker muscular dystrophy (DMD and BMD, respectively). Therefore, substantial efforts have been made to understand and therapeutically target skeletal muscle nNOS isoform signaling. The purpose of this review is to summarize recent salient advances in understanding of the regu...
Source: Nitric Oxide - November 29, 2018 Category: Chemistry Source Type: research
Recent advancements in the mechanism of nitric oxide signaling associated with hydrogen sulfide and melatonin crosstalk during ethylene-induced fruit ripening in plants
Publication date: Available online 19 November 2018Source: Nitric OxideAuthor(s): Soumya MukherjeeAbstractThe current review focuses on the significant role of nitric oxide (NO) in modulating ethylene-induced fruit ripening responses in plants. In this context, hydrogen sulfide (H2S) and melatonin mediated crosstalk mechanisms have been discussed with recent updates. Physiological and biochemical events associated with climacteric fruit ripening involves a plethora of effects mediated by these biomolecules. In the last few years of progress in fruit ripening physiology, the involvement of hydrogen sulfide in relation to NO...
Source: Nitric Oxide - November 21, 2018 Category: Chemistry Source Type: research
Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress
Publication date: Available online 16 November 2018Source: Nitric OxideAuthor(s): Mingzheng Peng, Lei Qiang, Yan Xu, Cuidi Li, Tao Li, Jinwu WangAbstractThe intracellular reactive oxygen species contribute to RANKL-induced osteoclastogenesis and osteolysis. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a redox-sensitive transcription factor, is critical in the cellular defense against oxidative stress by induction of antioxidants and cytoprotective enzymes. In the current study, it was first demonstrated that RANKL-induced osteoclastogenesis and hydroxylapatite resorption were suppressed by Corosolic acid (CA) via in...
Source: Nitric Oxide - November 17, 2018 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 December 2018Source: Nitric Oxide, Volume 81Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - November 14, 2018 Category: Chemistry Source Type: research
Nitric oxide regulates intussusceptive-like angiogenesis in wound repair in chicken embryo and transgenic zebrafish models
Publication date: Available online 12 November 2018Source: Nitric OxideAuthor(s): Selvaraj Vimalraj, Sivakamasundari Pichu, Thyagarajan Pankajam, Kasiviswanathan Dharanibalan, Valentin Djonov, Suvro ChatterjeeAbstractAngiogenesis is the formation of new blood vessels that occurs by two distinct processes following sprouting angiogenesis (SA) and intussusceptive angiogenesis (IA). Nitric oxide (NO) is known for its pro-angiogenic functions. However, no clear mechanisms are delineated on its role in promoting angiogenesis in reparative wound healing. We propose that NO regulates SA to IA transition and vice versa in wound mi...
Source: Nitric Oxide - November 12, 2018 Category: Chemistry Source Type: research
l-proline supplementation improves nitric oxide bioavailability and counteracts the blood pressure rise induced by angiotensin II in rats
Publication date: Available online 10 November 2018Source: Nitric OxideAuthor(s): Joana Leal, Luísa Teixeira-Santos, Dora Pinho, Joana Afonso, Jorge Carvalho, Maria de Lourdes Bastos, António Albino-Teixeira, Sónia Fraga, Teresa SousaAbstractWe evaluated whether l-proline (Pro) supplementation improves redox status and nitric oxide (NO) bioavailability and prevents or delays angiotensin II (AngII)-induced hypertension.Male Sprague-Dawley rats were distributed to four experimental groups: Pro + AngII (Pro-Ang), Pro + Saline (Pro-Sal), Vehicle + AngII (Veh-Ang) and Veh + Saline (Veh-Sal). Pro solution (2 g kg−...
Source: Nitric Oxide - November 11, 2018 Category: Chemistry Source Type: research
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
Publication date: Available online 28 October 2018Source: Nitric OxideAuthor(s): Michael A. Hollas, Manel Ben Aissa, Sue H. Lee, Jesse M. Gordon-Blake, Gregory R.J. ThatcherAbstractThe development of small molecule modulators of NO/cGMP signaling for use in the CNS has lagged far behind the use of such clinical agents in the periphery, despite the central role played by NO/cGMP in learning and memory, and the substantial evidence that this signaling pathway is perturbed in neurodegenerative disorders, including Alzheimer's disease. The NO-chimeras, NMZ and Nitrosynapsin, have yielded beneficial and disease-modifying respon...
Source: Nitric Oxide - October 29, 2018 Category: Chemistry Source Type: research
Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman
Publication date: Available online 27 October 2018Source: Nitric OxideAuthor(s): Adrian J. Hobbs (Source: Nitric Oxide)
Source: Nitric Oxide - October 27, 2018 Category: Chemistry Source Type: research
H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures
Publication date: Available online 25 October 2018Source: Nitric OxideAuthor(s): Smriti Juriasingani, Masoud Akbari, Justin YH. Chan, Matthew Whiteman, Alp SenerAbstractRenal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys. The use of sub-optimal grafts obtained via donation after cardiac death (DCD) is on the rise. While static cold storage (SCS) in University of Wisconsin (UW) solution on ice (4 °C) is the clinical standard of care for renal graft preservation, cold storage has been associated with negative...
Source: Nitric Oxide - October 25, 2018 Category: Chemistry Source Type: research
Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway
Publication date: 1 December 2018Source: Nitric Oxide, Volume 81Author(s): Elie Nader, Marijke Grau, Romain Fort, Bianca Collins, Giovanna Cannas, Alexandra Gauthier, Katja Walpurgis, Cyril Martin, Wilhelm Bloch, Solène Poutrel, Arnaud Hot, Céline Renoux, Mario Thevis, Philippe Joly, Marc Romana, Nicolas Guillot, Philippe ConnesAbstractHydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell anemia (SCA). However, little is known about the HU NO-related effects on red blood cell (RBC) physiology and NO signalling pathway.Thirty-four patients with SCA (22 under HU treatment (HU+) and 12 witho...
Source: Nitric Oxide - October 23, 2018 Category: Chemistry Source Type: research
Hydroxyurea therapy modulates sickle cell anaemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway
Publication date: Available online 19 October 2018Source: Nitric OxideAuthor(s): Elie Nader, Marijke Grau, Romain Fort, Bianca Collins, Giovanna Cannas, Alexandra Gauthier, Katja Walpurgis, Cyril Martin, Wilhelm Bloch, Solène Poutrel, Arnaud Hot, Céline Renoux, Mario Thevis, Philippe Joly, Marc Romana, Nicolas Guillot, Philippe ConnesAbstractHydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell anemia (SCA). However, little is known about the HU NO-related effects on red blood cell (RBC) physiology and NO signalling pathway.Thirty-four patients with SCA (22 under HU treatment (HU+) and 12...
Source: Nitric Oxide - October 20, 2018 Category: Chemistry Source Type: research
Endogenous hydrogen sulfide (H2S) is up-regulated during sweet pepper (Capsicum annuum L.) fruit ripening. In vitro analysis shows that NADP-dependent isocitrate dehydrogenase (ICDH) activity is inhibited by H2S and nitric oxide
Publication date: Available online 13 October 2018Source: Nitric OxideAuthor(s): María A. Muñoz-Vargas, Salvador González-Gordo, Amanda Cañas, Javier López-Jaramillo, José M. Palma, Francisco J. CorpasAbstractLike nitric oxide (NO), hydrogen sulfide (H2S) has been recognized as a new gasotransmitter which plays an important role as a signaling molecule in many physiological processes in higher plants. Although fruit ripening is a complex process associated with the metabolism of reactive oxygen species (ROS) and nitrogen oxygen species (RNS), little is known about the potential involvement of endogenous H2S. Using sw...
Source: Nitric Oxide - October 14, 2018 Category: Chemistry Source Type: research
Editorial Board
Publication date: 1 November 2018Source: Nitric Oxide, Volume 80Author(s): (Source: Nitric Oxide)
Source: Nitric Oxide - October 11, 2018 Category: Chemistry Source Type: research
